Protein Alignment P4HA2 and CG18749

DIOPT Version :9

• Sequence 1: NP_001136071.1
• Gene: P4HA2 / 8974
• HGNCID: 8547
• Length: 535
• Species: Homo sapiens
• Sequence 2: NP_001027154.1
• Gene: CG18749 / 3771984
• FlyBaseID: FBgn0042182
• Length: 491
• Species: Drosophila melanogaster
• Alignment Length: 573
• Identity: 157/573 - (27%)
• Similarity: 243/573 - (42%)
• Gaps: 144/573 - (25%)

Human     2 KLWVSALLMAWFGVLSC-------VQAEFFTSIGHMTDLIYAEKELVQSLKEYILVEEAKLSKIK 59
            ||.....|.|.|  ::|       .:..:..|...:..|:..|.|||.:||.|:...:.|.:.::
  Fly     6 KLTFIGFLSACF--INCQGFVNSNPKKSYAASTMELMKLLEVEDELVDNLKGYVKTLKMKFNLME 68

Human    60 SWANKMEALTSKSAADAEGYLAHPVNAYKLVKRLNTDWPALED--LVLQDSAAGFIANLSVQRQF 122
            .....|.....:..:|.|.||.:|:|:::|:.||:|.|.....  :.::::|.|.|.|..:.|:.
  Fly    69 RSLIDMSRENMEMKSDYESYLGNPLNSFRLIHRLHTSWRKWYQYAIKVENNALGHIENARLMRKM 133

Human   123 FPTDEDEIGAAKALMRLQDTYRLDPGTISRGEL-----PGTKYQAMLSVDDCFGMGR-SAYNEGD 181
            .||..|...|.:.:..|...|.|.|..::.|.|     |||.    |:..||..:|. ...|:.|
  Fly   134 LPTSSDLQQACRGIHDLMYFYDLKPEELAAGNLAGYSQPGTG----LTAYDCLALGEFGVQNQKD 194

Human   182 YYHTVLWMEQVLKQLDAGEEATTTKSQVLDYLSYAVFQLGDLHRA---LELTRRLLSLDPSHERA 243
                                                    ||..|   |.|||
  Fly   195 ----------------------------------------DLAEAWYNLSLTR------------ 207

Human   244 GGNLRYFEQLLEE-----------EREKTLTNQTEAELATPEGIYERPVDYLPERDVYESLCRGE 297
                  |:.::|:           .:.|.||...:.....||||.           ....:...|
  Fly   208 ------FDNIIEKYQVHKAWALLLAKNKQLTEAFQHFENKPEGIV-----------ASNEVIHFE 255

Human   298 GVKLTPRR--------QKRLFCRYHHGNRAPQLLIAPFKEEDEWDSPHIVRYYDVMSDEEIERIK 354
            ||..|.:.        .|:|.||| :.:..|...|||.|.|:....|::|.::||:.|.||:
  Fly   256 GVLATTQNCTAVVQKPSKKLHCRY-NTSTTPFTRIAPLKMEELGLDPYMVVFHDVIYDTEID--- 316

Human   355 EIAKPKLARATVRDPKTGVLTVASYRVSKS-SWLEED-----DDPVV--ARVNRRMQHITGLTVK 411
                             |:|..:.:.:|:| |.|:.:     |..:|  ..:|.|:..:|||:::
  Fly   317 -----------------GMLNSSDFGLSESVSGLKSEVRTSKDSHIVDAKTLNERVTDMTGLSME 364

Human   412 TAELLQVANYGVGGQYEPHFDFSRNDERDTFKHLGTGNRVATFLNYMSDVEAGGATVFPDLGAAI 476
            .::...:.|||:||.:..|.||   .|......|..|:|:||.|.|:.:|::|||||||.|...:
  Fly   365 MSDPFSLINYGLGGHFILHHDF---HEYTNTTRLKQGDRIATVLFYLREVDSGGATVFPMLNITV 426

Human   477 WPKKGTAVFWYNLLRSGEGDYRTRHAACPVLVGCKWVSNKWFHERGQEFLRPC 529
            .||||:|||||||..||..:.:|.|.||||:.|.|:|..||.:|..|.|:.||
  Fly   427 MPKKGSAVFWYNLHNSGAVNSKTLHTACPVISGSKYVLTKWINELPQMFVTPC 479

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
P4HA2	NP_001136071.1	P4Ha_N	26..155	CDD:311993	36/130 (28%)
		TPR	207..240		7/35 (20%)
		P4Hc	346..519	CDD:214780	65/180 (36%)
CG18749	NP_001027154.1	P4Ha_N	35..166	CDD:285528	36/130 (28%)
		P4Hc	314..468	CDD:214780	63/176 (36%)

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0000199
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR10869
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X129
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	4	4.010