Protein Alignment P4HA2 and PH4alphaNE3

DIOPT Version :9

• Sequence 1: NP_001136071.1
• Gene: P4HA2 / 8974
• HGNCID: 8547
• Length: 535
• Species: Homo sapiens
• Sequence 2: NP_651814.1
• Gene: PH4alphaNE3 / 326114
• FlyBaseID: FBgn0051017
• Length: 481
• Species: Drosophila melanogaster
• Alignment Length: 526
• Identity: 146/526 - (27%)
• Similarity: 245/526 - (46%)
• Gaps: 89/526 - (16%)

Human    22 EFFTSIGHMTDLIYAEKELVQSLKEYILVEEAKLSKIKSWANKMEALTSKSAADAEGYLAHPVNA 86
            ||..:.....||:..:.||:.:|..|....:.|.|::|..|.::......:....|.||.:|:::
  Fly    16 EFLDTESAKMDLMQLDVELIDNLMNYAEKIDEKASQLKRLAQELRQPLHSAKGREEEYLGNPLHS 80

Human    87 YKLVKRLNTDWPALEDLVLQDSAAGFIANLSVQRQFFPTDEDEIGAAKALMRLQDTYRLDPGTIS 151
            :.|::.:..||..||:.:.:......|..|..:....|...|...|:.::.|:.:||.:.|..::
  Fly    81 FPLIRHMYQDWRYLEEFMKKPVGEEEIQFLRRKLPELPWQVDTEEASVSIFRIAETYGMMPWDMA 145

Human   152 RGELPGTKYQAMLSVDDCFGMGRSAYNEGDYYHTVLWMEQVLKQLDAGEEATTTKSQVLDYLSYA 216
            .|.:...::.:.|...|||.:.:..:..|.:...:.|:             |.:|:::.:..| .
  Fly   146 NGLIDNVRFNSTLPALDCFEVAKMYFKWGYFKQALQWI-------------TISKARMKEEYS-G 196

Human   217 VFQLGDLHR---ALELTRRLLSLDPSHERAGGNLRYFEQLLEE----EREKTLTNQTEAELATPE 274
            |:::..::|   ||...|.|:.||...|.       .|.||::    :...:|.:|.:   |.|
  Fly   197 VYEVLGMNRQDVALLQARCLVELDRRDEA-------HEVLLDQPDLADNSISLLDQFK---ANP- 250

Human   275 GIYERPVDYLPE-RDVYESLCRGEGVKLTPRRQKRLFCRYHHGNRAPQLLIAPFKEEDEWDSPHI 338
              || .:|..|: .:.|:.|||.   ..:|...| |.|||:....| .|::||.|.|:....|||
  Fly   251 --YE-AIDSSPKLGEGYKRLCRS---SFSPNPSK-LHCRYNSTTSA-FLILAPLKMEEISLEPHI 307

Human   339 VRYYDVMSDEEIERIKEIAKPKL------------ARATVRDPKTGVLTVASYRVSKSSWLEEDD 391
            |.|:|::.|::|:::..:|:|.|            ||::.|.|..|
  Fly   308 VVYHDILPDKDIQQLITLAEPLLKPTEMFDDNKNEARSSYRTPLGG------------------- 353

Human   392 DPVVARVNRRMQHITGLTVKTAELLQVANYGVGGQYEPHFDF--SRNDERDTFKHLGTGNRVATF 454
             |::..:.:||:.||||.::....:.:..||.|..|..::||  .||.|..     |.|:|:|||
  Fly   354 -PLLDSLTQRMRDITGLQIRQGNPINIIKYGFGAPYTNYYDFFKKRNSESK-----GFGDRMATF 412

Human   455 LNYMSDVEAGGATVFPDLGAAIWPKKGTAVFWYNLLRSGEGDYR-----TRHAACPVLVGCKWVS 514
            :.|::|...|||||||.|...:..::|..:|||||    .||..     |.||||||..|.|||.
  Fly   413 MFYLNDAPYGGATVFPRLNVKVPAERGKVLFWYNL----NGDTHDMEPTTMHAACPVFHGSKWVM 473

Human   515 NKWFHE 520
            ..|.||
  Fly   474 TAWIHE 479

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
P4HA2	NP_001136071.1	P4Ha_N	26..155	CDD:311993	29/128 (23%)
		TPR	207..240		9/35 (26%)
		P4Hc	346..519	CDD:214780	62/191 (32%)
PH4alphaNE3	NP_651814.1	P4Ha_N	25..149	CDD:285528	29/123 (24%)
		P4Hc	316..478	CDD:214780	62/190 (33%)

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D192165at33208
OrthoFinder	1	1.000	-	-		FOG0000199
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR10869
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X129
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	5	5.020