Protein Alignment P4HA2 and CG31016

DIOPT Version :10

• Sequence 1: NP_004190.1
• Gene: P4HA2 / 8974
• HGNCID: 8547
• Length: 535
• Species: Homo sapiens
• Sequence 2: NP_733393.3
• Gene: CG31016 / 326113
• FlyBaseID: FBgn0051016
• Length: 536
• Species: Drosophila melanogaster
• Alignment Length: 539
• Identity: 157/539 - (29%)
• Similarity: 264/539 - (48%)
• Gaps: 51/539 - (9%)

Human     8 LLMAWFGVLSCVQAEFFTSIGHMTDLIYAEKELVQSLKEYILVEEAKLSKIKSWANKMEALTSKS 72
            |:::|.......:..:..|:....||:..::||:..|..|......|:..:|....:.:....|:
  Fly    13 LVLSWIAEGYRDRQNYVISVEEKMDLLEKDRELIIVLDSYATELNEKIIMLKRIVKEFKQPLEKA 77

Human    73 AADAEGYLAHPVNAYKLVKRLNTDWPALEDLVLQDSAAGFIANLSVQRQFFPTDEDEIGAAKALM 137
            ....|.||::|:::..|:::::.||..:|.|:.:......||.:...|:..|.:.|.:.|.:|:.
  Fly    78 KNREEEYLSNPIDSLSLMRQMHEDWEKVEKLLKKPVGQEKIALVEKMREDLPVENDLMEANQAMF 142

Human   138 RLQDTYRLDPGTISRGELPGTKYQAMLSVDDCFGMGRSAYNEGDYYHTVLWMEQVLKQL-----D 197
            |:..||.|:|..:|.|.:.|.:|...:|..|||.||..::..|.|.....|:......|     .
  Fly   143 RILHTYDLEPKDVSAGWIDGVQYGGKMSASDCFTMGTFSFMAGSYQIASKWLSAAKDLLVDQPRK 207

Human   198 AGEEATTTKSQVLDYLSYAVFQLGDLHRALELTRRLLSLDPSHERAGGNLR-YFEQLLEEEREKT 261
            ..|....||:.|...|:.::...|::..|.::..|    |.....||..|. :|
  Fly   208 YHEVMGITKADVTLLLARSLIASGNVSIATDMLMR----DFMFGEAGSALTVHF----------- 257

Human   262 LTNQTEAELATPEGIYERPVDYLPERDVYESLCRGEGVKLTPRRQ------KRLFCRYHHGNRAP 320
            |.|:.:..:         .::.....:.:..|||.     :.|||      .||.||| :....|
  Fly   258 LRNKPKPSI---------NLESWESDESFNQLCRS-----SSRRQMGESKPSRLHCRY-NTITTP 307

Human   321 QLLIAPFKEEDEWDSPHIVRYYDVMSDEEIERIKEIAKPKLARATVRDPKTGVLTVASYRVSKSS 385
            .|.:|||:.|:....|:::.|::|:||.|||::|.:.||.|.||.|...:.|...:...|.:..:
  Fly   308 FLKLAPFRMEELSLDPYVIFYHNVLSDAEIEKLKPMGKPFLERAKVFRVEKGSDEIDPSRSADGA 372

Human   386 WL-----EEDDDPVVARVNRRMQHITGLTVKTAELLQVANYGVGGQYEPHFDFSRNDERDTFKHL 445
            ||     :.||..|:.|:.||::.:|||..::...:|...||.||.:.||:|:..:   .||...
  Fly   373 WLPHQNIDPDDLEVLNRIGRRIEDMTGLNTRSGSKMQFLKYGFGGHFVPHYDYFNS---KTFSLE 434

Human   446 GTGNRVATFLNYMSDVEAGGATVFPDLGAAIWPKKGTAVFWYNLLR-SGEGDYRTRHAACPVLVG 509
            ..|:|:||.|.|:::|:.|||||||.|..|:..:||:|:||:|:.| |.:.|.||.|.|||::.|
  Fly   435 TVGDRIATVLFYLNNVDHGGATVFPKLNLAVPTQKGSALFWHNIDRKSYDYDTRTFHGACPLISG 499

Human   510 CKWVSNKWFHERGQEFLRP 528
            .|.|..:|.:|..|.||.|
  Fly   500 TKLVMTRWIYELDQMFLIP 518

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
P4HA2	NP_004190.1	P4Ha_N	26..157	CDD:462433	33/130 (25%)
		BamD	159..>272	CDD:443281	26/118 (22%)
		TPR	207..240		6/32 (19%)
		P4Hc	346..519	CDD:214780	70/178 (39%)
CG31016	NP_733393.3	P4Ha_N	31..162	CDD:462433	33/130 (25%)
		P4Hc	333..508	CDD:214780	69/177 (39%)