Protein Alignment P4HA2 and PH4alphaSG1

DIOPT Version :9

• Sequence 1: NP_001136071.1
• Gene: P4HA2 / 8974
• HGNCID: 8547
• Length: 535
• Species: Homo sapiens
• Sequence 2: NP_733376.1
• Gene: PH4alphaSG1 / 326112
• FlyBaseID: FBgn0051014
• Length: 540
• Species: Drosophila melanogaster
• Alignment Length: 526
• Identity: 179/526 - (34%)
• Similarity: 281/526 - (53%)
• Gaps: 29/526 - (5%)

Human    19 VQAEFFTSIGHMTDLIYAEKELVQSLKEYILVEEAKLSKIKSWANKMEALTSKSAADAEGYLAHP 83
            |..:::::|..:..|:..|..:|:...||:...:.:...:|.:.::::. ......|.|.|..:|
  Fly    16 VNGDYYSAISELERLLDVEAFIVEKFDEYLERAQQEQENLKRFLDQIDE-QQNDRGDLEEYFGNP 79

Human    84 VNAYKLVKRLNTDWP--ALEDLVLQDSAAGFIANL--SVQRQFF--PTDEDEIGAAKALMRLQDT 142
            :||:..:|||..||.  ..:.:....:...:..||  |:::..|  ||.||..||.:||:|||:.
  Fly    80 INAFITIKRLVHDWKFNVFDPVFDSSNFETYKNNLSDSLEKINFKGPTQEDLHGATRALLRLQNM 144

Human   143 YRLDPGTISRGEL-PGTK--YQAMLSVDDCFGMGRSAYNEGDYYHTVLWMEQVLKQLDAGE---- 200
            |:|:...::.|.| ||.|  ....||..|||.:|::.....:|.:...|:.:..|:|....
  Fly   145 YQLNTDHLASGVLHPGEKNALGTSLSASDCFELGKNLCEIKEYSYGSEWLLEARKRLHGKPLGFI 209

Human   201 EATTTKSQVLDYLSYAVFQLGDLHRALELTRRLLSLDPSHERAGGNLRYFEQLLEEEREKTLTNQ 265
            ....:..::|::||.|...||:|..|.:|...:|...|.||.|..|...:|..|..||......|
  Fly   210 SPNVSDVEILEHLSSAFNGLGNLKLAYKLNNEILDKKPDHEEALKNKILYEGQLARERSFAPRKQ 274

Human   266 TEAELATPEGIYERPVDYLPERDVYESLCRGEGVKLTPRRQKRLFC-RYHHGNRAPQLLIAPFKE 329
            .|......:   |:...|    .:|..:|||| :..:||.|:.|.| .||.|  .|...::|||.
  Fly   275 VELPQIAEK---EQKESY----KLYTQVCRGE-LHQSPREQRNLRCWLYHQG--VPYYRLSPFKI 329

Human   330 EDEWDSPHIVRYYDVMSDEEIERIKEIAKPKLARATVRDPKTGVLTVASYRVSKSSWLEEDDDPV 394
            |.....|::...::|:.|.||:.|.|..|..:.|:.|...:..  |.:..|:|:::||..|.:|.
  Fly   330 EQLNVDPYVAYVHEVLWDSEIDTIMEHGKGNMERSKVGQSENS--TTSEVRISRNTWLWYDANPW 392

Human   395 VARVNRRMQHITGLTVKTAELLQVANYGVGGQYEPHFDFSRNDERDTFKHLGTGNRVATFLNYMS 459
            ::::.:|::.:|||:.::||.||:.|||:||||||||||..:|.:..|.  ..|||:.|.|.|::
  Fly   393 LSKIKQRLEDVTGLSTESAEPLQLVNYGIGGQYEPHFDFVEDDGQSVFS--WKGNRLLTALFYLN 455

Human   460 DVEAGGATVFPDLGAAIWPKKGTAVFWYNLLRSGEGDYRTRHAACPVLVGCKWVSNKWFHERGQE 524
            ||..||||.||.|..|:.|.||:.:.||||..|...|:||:||.||||.|.||:.|:|||...||
  Fly   456 DVALGGATAFPFLRLAVPPVKGSLLIWYNLHSSTHKDFRTKHAGCPVLQGSKWICNEWFHVGAQE 520

Human   525 FLRPCG 530
            |.||||
  Fly   521 FRRPCG 526

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
P4HA2	NP_001136071.1	P4Ha_N	26..155	CDD:311993	36/134 (27%)
		TPR	207..240		11/32 (34%)
		P4Hc	346..519	CDD:214780	76/172 (44%)
PH4alphaSG1	NP_733376.1	P4Ha_N	23..157	CDD:285528	36/134 (27%)
		P4Hc	347..515	CDD:214780	76/171 (44%)

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D192165at33208
OrthoFinder	1	1.000	-	-		FOG0000199
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X129
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	4	3.920