DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment P4HA2 and CG31013

DIOPT Version :9

Sequence 1:	NP_001136071.1	Gene:	P4HA2 / 8974	HGNCID:	8547	Length:	535	Species:	Homo sapiens
Sequence 2:	NP_733394.3	Gene:	CG31013 / 326111	FlyBaseID:	FBgn0051013	Length:	534	Species:	Drosophila melanogaster

Alignment Length:	574	Identity:	167/574 - (29%)
Similarity:	259/574 - (45%)	Gaps:	105/574 - (18%)

- Green bases have known domain annotations that are detailed below.

Human    10 MAWFGVLSCVQAEFFTS---IGH-------------MTDLIYAEKELVQSLKEYILVEEAKLSKI 58
            |.:|  :.|:....|.|   :||             |..|:..||:|:.:|:.|....|.||..|
  Fly     1 MGYF--IRCLLVMLFHSTLVLGHRPLEKSHSLSLVTMVPLLELEKKLIDNLENYTNALEQKLEII 63

Human    59 KSWANKMEALTSKSAADAEGYLAHPVNAYKLVKRLNTDWPALEDLVLQDSAAGFIANLSVQRQFF 123
            :|....:.|...|...:|..||::|:|.:.:::||:.||......:.|......:......:...
  Fly    64 RSQLLVIRAENEKGRRNAISYLSNPLNGFSIIRRLHQDWINWRKYMEQPVGIWQLKAFYSWKDEL 128

Human   124 PTDEDEIGAAKALMRLQDTYRLDPGTISRGELPGTKYQAMLSVDDCFGMGRSAYNEGDYYHTVLW 188
            ||:.|...|.:.:.|:|.||.|..|....|.:.|.:|...:|..|...:|...:.:......:.|
  Fly   129 PTERDLWDACEGIARIQSTYDLKVGDFINGNINGKQYNDSMSTADILSVGAYLFMKNRPSDAIQW 193

Human   189 MEQV----------------LKQLDAGEEATTTKSQVLDYLSYAVFQLGDLHRALELTRRLLSLD 237
            :::|                :|::||           |..|:.|..:..:...||.|....|.|.
  Fly   194 LQEVPQRLQEELLIQPRHLPIKEVDA-----------LRLLAEAQIKDQNYSEALPLLHNCLKLQ 247

Human   238 PSHERAGGNLRYFEQ---LLEEEREKTLTNQTEAELATPEGIYERPVDYLPERDVYESLCRGEGV 299
            |...|.   ||.:::   .:|.:.:::.|...:..              :|..:.::..|.|...
  Fly   248 PHDARV---LRLWKKTTDFIENQPDQSPTENKKRN--------------VPIANAFKLSCNGPLE 295

Human   300 KLTPRRQKRLFCRYHHGNRAPQLLIAPFKEEDEWDSPHIVRYYDVMSDEEIERI----------- 353
            ..|     ||.|.|:. ...|.|.:||.|.|.....|::|.|::|:|..||..:
  Fly   296 SST-----RLHCFYNF-TTTPFLRLAPLKTEQIGLDPYVVLYHEVLSAREISMLIGKAAQNMKNT 354

Human   354 ---KEIAKPKLARATVRDPKTGVLTVASYRVSKSSWLEEDDDPVVARVNRRMQHITGLTVKTAEL 415
               ||.|.||..|.               |.:|..||:::.:.:..|:.||:..:||..:..:|.
  Fly   355 KIHKERAVPKKNRG---------------RTAKGFWLKKESNELTKRITRRIMDMTGFDLADSEG 404

Human   416 LQVANYGVGGQYEPH---FDFSRNDERDTFKH--LGTGNRVATFLNYMSDVEAGGATVFPDLGAA 475
            .||.|||:||.|..|   |||:.::..||...  :..|:|:||.|.|::|||.||||||.|:|..
  Fly   405 FQVINYGIGGHYFLHMDYFDFASSNHTDTRSRYSIDLGDRIATVLFYLTDVEQGGATVFGDVGYY 469

Human   476 IWPKKGTAVFWYNLLRSGEGDYRTRHAACPVLVGCKWVSNKWFHERGQEFLRPC 529
            :.|:.|||:|||||...|.||.|||||||||:||.|||..:|..|:.|.|:|||
  Fly   470 VSPQAGTAIFWYNLDTDGNGDPRTRHAACPVIVGSKWVMTEWIREKRQIFIRPC 523

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
P4HA2	NP_001136071.1	P4Ha_N	26..155	CDD:311993	38/144 (26%)
		TPR	207..240		9/32 (28%)
		P4Hc	346..519	CDD:214780	77/191 (40%)
CG31013	NP_733394.3	P4Ha_N	31..160	CDD:285528	35/128 (27%)
		TPR_11	178..248	CDD:290150	14/80 (18%)
		TPR repeat	211..246	CDD:276809	10/45 (22%)
		P4Hc	336..513	CDD:214780	77/191 (40%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D192165at33208
OrthoFinder	1	1.000	-	-		FOG0000199
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR10869
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X129
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	5	5.020