DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment P4HA2 and CG31524

DIOPT Version :9

Sequence 1:	NP_001136071.1	Gene:	P4HA2 / 8974	HGNCID:	8547	Length:	535	Species:	Homo sapiens
Sequence 2:	NP_733379.2	Gene:	CG31524 / 318781	FlyBaseID:	FBgn0051524	Length:	536	Species:	Drosophila melanogaster

Alignment Length:	536	Identity:	170/536 - (31%)
Similarity:	257/536 - (47%)	Gaps:	44/536 - (8%)

- Green bases have known domain annotations that are detailed below.

Human    14 GVLSCVQAEFFTSIGHMTDLIYAEKELVQSLKEYILVEEAKLSKIKSWANKMEALTSKSAADAEG 78
            |.:...|..|..|:.:|.||:..|.:||..|:.|......|.:.|:....:|.....||..:...
  Fly    19 GQIEATQPRFARSVVNMDDLLNMEDDLVSKLEGYAEKLSYKANTIRWGIQQMREQLDKSKKEQSF 83

Human    79 YLAHPVNAYKLVKRLNTDW----PALEDLVLQDSAAGFIANLSVQRQFFPTDEDEIGAAKALMRL 139
            .|   .|.|..::.:..||    ..|:..|::|.    :....:.....|.:.|...|::|:.|:
  Fly    84 DL---FNRYSFIRHMQADWLMWKQYLDKPVIRDE----LNYKQMDNLRMPQELDLFDASEAIRRM 141

Human   140 QDTYRLDPGTISRGELPGTKYQAMLSVDDCFGMGRSAYNEGDYYHTVLWMEQVLKQLDAGEEAT- 203
            |.||.:....|:.|.|.|.:|.:.||..||..|||...|:..:.....|:...:|..|.....|
  Fly   142 QATYAMLSNDIAEGFLDGVQYTSKLSPIDCLAMGRHLMNQSRWTIAEQWILAGIKAQDRKGPQTE 206

Human   204 ------TTKSQVLDYLSYAVFQLGDLHRALELTRRLLSLDPSHERAGGNLRYFEQLLEEEREKTL 262
                  .||:::...|....|:..:...||:..:..|...| |:     |..|:: .:..:.:.|
  Fly   207 MILLRGPTKAELFRTLGKVRFERRNEEGALKAYQAALKHSP-HD-----LEIFQE-YQNLKRRVL 264

Human   263 TNQTEAELATPEGIYERPVDYLPERDVYESLCRG--EGVKLTPRRQKRLFCRYHHGNRAPQLLIA 325
            |      |:..|.|.|.|.|.:.|.:: ...|.|  ||    ||:..||:|.|:... ||.|.:|
  Fly   265 T------LSPSEPIREEPNDDIEEMEL-PPCCSGRCEG----PRKLNRLYCVYNCVT-APFLRLA 317

Human   326 PFKEEDEWDSPHIVRYYDVMSDEEIERIKEIAKPK-LARATVRDPKTGVLTVASYRVSKSSWLEE 389
            |.|.|.....|.::..:|::|.:|...|:..:|.: |...||.  ......:|.:|.|||.|.:.
  Fly   318 PIKTEILSVDPFVILLHDMVSHKEGALIRSSSKNQILPSETVN--AANEFEIAKFRTSKSVWFDS 380

Human   390 DDDPVVARVNRRMQHITGLTVKTAELLQVANYGVGGQYEPHFDFSRNDERDTFKHLGTGNRVATF 454
            |.:....::.:|:...|||.:|.:|..||.|||:||.:|.|||.|..|| |.|.: |..:|:||.
  Fly   381 DANEATLKLTQRLGEATGLDMKHSEPFQVINYGIGGVFESHFDTSLADE-DRFVN-GYIDRLATT 443

Human   455 LNYMSDVEAGGATVFPDLGAAIWPKKGTAVFWYNLLRSGEGDYRTRHAACPVLVGCKWVSNKWFH 519
            |.|::||..||||.||.|...::||.||.:.||||...|....||.|..|||:||.|||.:||..
  Fly   444 LFYLNDVPQGGATHFPGLNITVFPKFGTVLMWYNLHTEGMLHVRTMHTGCPVIVGSKWVVSKWID 508

Human   520 ERGQEFLRPCGSTEVD 535
            ::||||.|||..:.:|
  Fly   509 DKGQEFRRPCLRSRLD 524

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
P4HA2	NP_001136071.1	P4Ha_N	26..155	CDD:311993	32/132 (24%)
		TPR	207..240		6/32 (19%)
		P4Hc	346..519	CDD:214780	73/173 (42%)
CG31524	NP_733379.2	P4Ha_N	31..157	CDD:285528	32/132 (24%)
		TPR_11	215..>259	CDD:290150	10/50 (20%)
		TPR_2	216..249	CDD:285020	6/33 (18%)
		P4Hc	340..507	CDD:214780	71/170 (42%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D192165at33208
OrthoFinder	1	1.000	-	-		FOG0000199
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X129
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	4	3.920