DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment P4HA2 and CG32201

DIOPT Version :9

Sequence 1:	NP_001136071.1	Gene:	P4HA2 / 8974	HGNCID:	8547	Length:	535	Species:	Homo sapiens
Sequence 2:	NP_730346.2	Gene:	CG32201 / 317911	FlyBaseID:	FBgn0052201	Length:	520	Species:	Drosophila melanogaster

Alignment Length:	575	Identity:	158/575 - (27%)
Similarity:	255/575 - (44%)	Gaps:	99/575 - (17%)

- Green bases have known domain annotations that are detailed below.

Human     1 MKLWVSAL-LMAWFGVLSCVQAEFFTSIGHMTDLIYAEKELVQS----LKEYILVEEA----KLS 56
            |:.:.|.| ::..|.||:       :.:|.:.|:  .|||...|    |.:.:.|||.    .|:
  Fly     1 MRKYHSLLPVLLGFAVLN-------SFVGCVEDI--EEKERYSSSTVGLLKLLKVEEKFTDNLLN 56

Human    57 KIKSWANKMEAL----------TSKSAADAEGYLAHPVNAYKLVKRLNTDWPALEDLVLQDSAAG 111
            ::.....|.|||          ..:|..:...|:::|:||:.|::|.:.|.|...:...:....|
  Fly    57 QVDQLGEKFEALRMYLSSVGYELHRSLNEKVQYVSNPINAFSLLRRTHEDLPKWHEYFKEAIGEG 121

Human   112 FIANLSVQRQFFPTDEDEIGAAKALMRLQDTYRLDPGTISRGELPGTKYQAMLSVDDCFGMGRSA 176
            ..:.|....:..|.|.|.:.|...:.|::..|.|....:::|.|.|.:|...|:..|...||.|.
  Fly   122 NQSILVDLVKMVPNDVDMLSAMHGIQRIEKIYDLKIDDLAQGVLQGVQYNVQLTYRDLIAMGNSM 186

Human   177 YNEGDYYHTVLWMEQVLK-QLDAGEEATTTKSQVLDYLSYAVFQLGD----LHRALELTRRLLSL 236
            |.:.||.....|.....| :|:..|:...   |:          |||    |||  :..:.|...
  Fly   187 YQQSDYQTAAKWYRIACKRELENPEQLFI---QI----------LGDPSEHLHR--QYIKSLFKY 236

Human   237 DPSHERAGGNLR---YFEQLLEEEREKTLTNQTEAELATPEGIYERPVDYLPERDVY-------- 290
            ..:......::.   ...|..:||.:..:::..|     |:.      |...|:|:|
  Fly   237 GSTTSEPSKSIEEAFIMVQASQEELDNIMSDLNE-----PQN------DVEVEKDLYQVKRSPSN 290

Human   291 -ESLCRGEGVKLTPRRQKRLFCRYHHGNRAPQLLIAPFKEEDEWDSPHIVRYYDVMSDEEIERIK 354
             |..|||     ..|::..|.||| .......|.:||.|.|:....|.:..|::|:.|.||..:|
  Fly   291 CELGCRG-----LYRQKTNLVCRY-KSTANTFLRLAPLKLEEISLDPFMAMYHEVLYDSEIRELK 349

Human   355 EIA-------KPKLARATVRDPKTGVLTVASYR-VSKSSWLEEDDDPVVARVNRRMQHITGLTVK 411
            ..:       ..:.....:||      ||..|. .|.:|.:.|       |:|:|:..:||....
  Fly   350 GQSMNMVNGYASQRNGTEIRD------TVVRYDWWSNTSLVRE-------RINQRIIDMTGFNFL 401

Human   412 TAELLQVANYGVGGQYEPHFDFSRNDERDTFKHLGTGNRVATFLNYMSDVEAGGATVFPDLGAAI 476
            ..|.||:||||:|..::||||:| :|..:|......|:|:|:.|.|.|:|..|||||||::...:
  Fly   402 KDEKLQIANYGLGTYFQPHFDYS-SDGFETPNITTLGDRLASILFYASEVPQGGATVFPEINVTV 465

Human   477 WPKKGTAVFWYNLLRSGEGDYRTRHAACPVLVGCKWVSNKWFHERGQEFLRPCGS 531
            :|:||:.::|:||...|:.|.|:.|:.||||.|.:|...||.....|.|..||.|
  Fly   466 FPQKGSMLYWFNLHDDGKPDIRSLHSVCPVLNGDRWTLTKWVPMFPQMFSFPCKS 520

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
P4HA2	NP_001136071.1	P4Ha_N	26..155	CDD:311993	34/146 (23%)
		TPR	207..240		8/36 (22%)
		P4Hc	346..519	CDD:214780	64/180 (36%)
CG32201	NP_730346.2	P4Ha_N	36..165	CDD:285528	28/128 (22%)
CG32201	NP_730346.2	P4Hc	341..507	CDD:214780	63/179 (35%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D192165at33208
OrthoFinder	1	1.000	-	-		FOG0000199
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR10869
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X129
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	5	5.020