DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CHRNA6 and nAChRbeta1

DIOPT Version :9

Sequence 1:	NP_004189.1	Gene:	CHRNA6 / 8973	HGNCID:	15963	Length:	494	Species:	Homo sapiens
Sequence 2:	NP_523927.2	Gene:	nAChRbeta1 / 38545	FlyBaseID:	FBgn0000038	Length:	521	Species:	Drosophila melanogaster

Alignment Length:	482	Identity:	212/482 - (43%)
Similarity:	303/482 - (62%)	Gaps:	40/482 - (8%)

- Green bases have known domain annotations that are detailed below.

Human    34 EERLFHKLFSHYNQFIRPVENVSDPVTVHFEVAITQLANVDEVNQIMETNLWLRHIWNDYKLRWD 98
            ||||...||..||:.||||:|::..|.|.|.:|..||.||:|.||||::|:|||.:|.||:|:||
  Fly    28 EERLVRDLFRGYNKLIRPVQNMTQKVGVRFGLAFVQLINVNEKNQIMKSNVWLRLVWYDYQLQWD 92

Human    99 PMEYDGIETLRVPADKIWKPDIVLYNNAVGDFQVEGKTKALLKYNGMITWTPPAIFKSSCPMDIT 163
            ..:|.||..||:|.||:|||||||:|||.|:::|..|:..|:...|.:.|.||||::|||.:|:|
  Fly    93 EADYGGIGVLRLPPDKVWKPDIVLFNNADGNYEVRYKSNVLIYPTGEVLWVPPAIYQSSCTIDVT 157

Human   164 FFPFDHQNCSLKFGSWTYDKAEIDLLIIGSK--VDMNDFWENSEWEIIDASGYKHDIKYNCCEEI 226
            :||||.|.|.:||||||::..::.|.:..:|  ||::|:|::..|:||:...|.:..:.:.....
  Fly   158 YFPFDQQTCIMKFGSWTFNGDQVSLALYNNKNFVDLSDYWKSGTWDIIEVPAYLNVYEGDSNHPT 222

Human   227 YTDITYSFYIRRLPMFYTINLIIPCLFISFLTVLVFYLPSDCGEKVTLCISVLLSLTVFLLVITE 291
            .||||:...|||..:|||:|||:|.:.||||.|||||||::.||||||.||:||||.||||::::
  Fly   223 ETDITFYIIIRRKTLFYTVNLILPTVLISFLCVLVFYLPAEAGEKVTLGISILLSLVVFLLLVSK 287

Human   292 TIPSTSLVVPLVGEYLLFTMIFVTLSIVVTVFVLNIHYRTPTTHTMPRWVKTVFLKLLPQVLLMR 356
            .:|.||||:||:.:|||||.|..|:||:|||.::|.::|.|.||.||.:::::||..||..|.|:
  Fly   288 ILPPTSLVLPLIAKYLLFTFIMNTVSILVTVIIINWNFRGPRTHRMPMYIRSIFLHYLPAFLFMK 352

Human   357 WPLDKTR--------GTGSDAVPRGLARRPAK--------GKLASHGEPRHLKECFH--C---HK 400
            .| .|||        |....|.|......||:        |...|..|...|.:..|  |   .|
  Fly   353 RP-RKTRLRWMMEMPGMSMPAHPHPSYGSPAELPKHISAIGGKQSKMEVMELSDLHHPNCKINRK 416

Human   401 SNE-----LATSKRRLSHQPLQWVVENSEH---SPEVEDVINSVQFIAENMKSHNETKEVEDDWK 457
            .|.     |....||.|        |:|:.   |||......:|:||||::::.:...:..:|||
  Fly   417 VNSGGELGLGDGCRRES--------ESSDSILLSPEASKATEAVEFIAEHLRNEDLYIQTREDWK 473

Human   458 YVAMVVDRVFLWVFIIVCVFGTAGLFL 484
            |||||:||:.|::|.||...||.|:.:
  Fly   474 YVAMVIDRLQLYIFFIVTTAGTVGILM 500

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CHRNA6	NP_004189.1	Neur_chan_LBD	34..484	CDD:332142	212/480 (44%)
nAChRbeta1	NP_523927.2	LIC	8..500	CDD:273305	212/480 (44%)
		Neur_chan_LBD	28..236	CDD:280998	98/207 (47%)
		Neur_chan_memb	243..498	CDD:280999	109/263 (41%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG3645
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D188416at33208
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR18945
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	4	3.920