Protein Alignment AP3D1 and g

DIOPT Version :9

• Sequence 1: NP_001248755.1
• Gene: AP3D1 / 8943
• HGNCID: 568
• Length: 1215
• Species: Homo sapiens
• Sequence 2: NP_524785.2
• Gene: g / 44819
• FlyBaseID: FBgn0001087
• Length: 1034
• Species: Drosophila melanogaster
• Alignment Length: 1060
• Identity: 582/1060 - (54%)
• Similarity: 733/1060 - (69%)
• Gaps: 108/1060 - (10%)

Human     1 MALKMVKGS-IDRMFDKNLQDLVRGIRNHKEDEAKYISQCIDEIKQELKQDNIAVKANAVCKLTY 64
            ||||.|||: .:|||||||.||||||||:|::||||||.||:||||||:||||:||.|||.||||
  Fly     1 MALKKVKGNFFERMFDKNLTDLVRGIRNNKDNEAKYISTCIEEIKQELRQDNISVKCNAVAKLTY 65

Human    65 LQMLGYDISWAAFNIIEVMSASKFTFKRIGYLAASQSFHEGTDVIMLTTNQIRKDLSSPSQYDTG 129
            :||||||||||.||||||||:|:||.||||||||||.||..::::|||||.|||||:|.:|||.|
  Fly    66 IQMLGYDISWAGFNIIEVMSSSRFTCKRIGYLAASQCFHPDSELLMLTTNMIRKDLNSQNQYDAG 130

Human   130 VALTGLSCFVTPDLARDLANDIMTLMSHTKPYIRKKAVLIMYKVFLKYPESLRPAFPRLKEKLED 194
            |||:|||||::|||:||||||||||||.||||:|.||||:||||||:|||:||||||:|||||||
  Fly   131 VALSGLSCFISPDLSRDLANDIMTLMSSTKPYLRMKAVLMMYKVFLRYPEALRPAFPKLKEKLED 195

Human   195 PDPGVQSAAVNVICELARRNPKNYLSLAPLFFKLMTSSTNNWVLIKIIKLFGALTPLEPRLGKKL 259
            ||||||||||||||||||:||||||.|||:||||||:|||||:||||||||||||||||||||||
  Fly   196 PDPGVQSAAVNVICELARKNPKNYLPLAPIFFKLMTTSTNNWMLIKIIKLFGALTPLEPRLGKKL 260

Human   260 IEPLTNLIHSTSAMSLLYECVNTVIAVLISLSSGMPNHSASIQLCVQKLRILIEDSDQNLKYLGL 324
            ||||||||||||||||||||:|||||||||:||||||||||||||||||||||||||||||||||
  Fly   261 IEPLTNLIHSTSAMSLLYECINTVIAVLISISSGMPNHSASIQLCVQKLRILIEDSDQNLKYLGL 325

Human   325 LAMSKILKTHPKSVQSHKDLILQCLDDKDESIRLRALDLLYGMVSKKNLMEIVKKLMTHVDKAEG 389
            |||||||||||||||:||||||.|||||||||||||||||||||||||||||||:|:.|:::|||
  Fly   326 LAMSKILKTHPKSVQAHKDLILACLDDKDESIRLRALDLLYGMVSKKNLMEIVKRLLGHMERAEG 390

Human   390 TTYRDELLTKIIDICSQSNYQYITNFEWYISILVELTRLE-GTRHGHLIAAQMLDVAIRVKAIRK 453
            :.||||||.|:|:||:||:|.|:||||||:::||||.:|| |:|||.|||.|:|||||||..:|:
  Fly   391 SAYRDELLYKVIEICAQSSYLYVTNFEWYLTVLVELIQLEAGSRHGRLIAEQLLDVAIRVPVVRQ 455

Human   454 FAVSQMSALLDSAHLLASSTQRNGICEVLYAAAWICGEFSEHLQEPHHTLEAMLRPRVTTLPGHI 518
            |||::|:.|||:   ...|.|.|.:.|||||||||.|||:..|::...||..:||||:  |||||
  Fly   456 FAVNEMTNLLDT---FTVSAQSNSMYEVLYAAAWIVGEFAGELEDAEKTLNILLRPRL--LPGHI 515

Human   519 QAVYVQNVVKLYASILQQKEQAGEAEGAQAVTQLMVDRLPQFVQSADLEVQERASCILQLVKHIQ 583
            |.||||||:||:|.:.....:..:..|...:...::|:|..|..|:|:||||||:....|::.::
  Fly   516 QGVYVQNVIKLFARLATTCLELQDLPGLVTLCDHVLDKLQHFNGSSDIEVQERANSACMLIEMLR 580

Human   584 K-------LQAKD-----------VPVAEEVSALFAGELNPVAPKAQKKVPVPEGLDLDAWINEP 630
            .       ..|.|           :.:.:|::.||.|||.|||||||:|||:|:|||||.|||.|
  Fly   581 NQLSTSTDAMAMDTTTEGGIPPLAIEIVQEMTLLFTGELIPVAPKAQRKVPLPDGLDLDEWINAP 645

Human   631 -----LSDSESEDERPRAVFHEEEQR------RPKHRPS-EADEEELARRREARKQEQANNPFYI 683
                 .|.|.||.::.. :|....|.      ..|.|.| |...|:|.|:|.||..||:|||.|:
  Fly   646 PPEDAASSSSSEHDKDE-LFVSATQAGTGADGGEKRRQSLELTPEQLERQRMARLIEQSNNPHYL 709

Human   684 KSSP-----SPQKRYQDTPGVEHIPVVQIDLSV----PLKVPGLPMSDQYVKLEEERRHRQKLEK 739
            ||:|     |...:|.:   ::.||:.::.|.:    .|:|.....||:|:: |::.....|..|
  Fly   710 KSTPTASGASNADQYDN---IDDIPITELPLDMEGVAALRVGITKRSDKYLQ-EQQAAQGSKDGK 770

Human   740 DKRRKKRKEKEKKGKRRHSSLPTESDEDIAPAQQVDIVTEEMPENALPSDEDDK----DPNDPYR 800
            .|.:|.:|.|:.|.|..::| .:||:.:..|...|: .|.:|||....||.:||    |||||:|
  Fly   771 KKHKKGKKSKKAKNKVAYNS-SSESEGEPKPLHIVN-TTLDMPEGVSMSDSEDKDGKYDPNDPHR 833

Human   801 ALDIDLD--------------KPLADSEKLPIQKHRNTETSKSPEKDV---PMVEKKSKKPKKKE 848
            ||||:||              |..||.|.|           |:|....   ...:|..||.|.|:
  Fly   834 ALDIELDITEFEAPAVRSASKKSAADKENL-----------KTPADSAGGGNAAKKDRKKDKDKD 887

Human   849 KKHKEKERDKEKKKEKEKKAED--LDFWLSTTPPPAPAPAPAPVPSTGELSVNTV--TTPK---- 905
            |:.|.|...:|.|:|:::.|..  :|...:.||.|:|:...|   ::...:.:||  ..||
  Fly   888 KERKVKREHRESKRERKEAAVQSVIDLIDADTPTPSPSHISA---TSNNNNTSTVLPDAPKHHKK 949

Human   906 --------DECEDAKTEAQGEE-DDAEGQDQDKKSPKPKKKKHRKEKEERTKGKKKSKKQPPGSE 961
                    ||..||...|.|.. .|..|::..:.:.|..||||:|||.:|.:.||.|:.....:.
  Fly   950 KKNKEKTTDEAPDALATATGSSIIDVGGEEASEVASKVHKKKHKKEKSQRKEKKKASESASVSAI 1014

Human   962 EAAG---EPVQNGAPEEEQL 978
            .:.|   :|:....|.:|.|
  Fly  1015 VSIGDYEQPLGISTPSKEIL 1034

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
AP3D1	NP_001248755.1	Adaptin_N	32..581	CDD:279882	408/549 (74%)
		HEAT repeat	151..172	CDD:293787	16/20 (80%)
		Cnd1	155..265	CDD:289487	97/109 (89%)
		HEAT repeat	184..212	CDD:293787	26/27 (96%)
		HEAT repeat	220..262	CDD:293787	37/41 (90%)
		HEAT repeat	271..292	CDD:293787	18/20 (90%)
		HEAT repeat	301..330	CDD:293787	28/28 (100%)
		HEAT repeat	335..364	CDD:293787	26/28 (93%)
		BLVR	661..807	CDD:283923	57/158 (36%)
g	NP_524785.2	Adaptin_N	33..578	CDD:279882	408/549 (74%)
		HEAT repeat	152..173	CDD:293787	16/20 (80%)
		HEAT repeat	185..213	CDD:293787	26/27 (96%)
		Cnd1	<193..266	CDD:289487	67/72 (93%)
		HEAT repeat	221..263	CDD:293787	37/41 (90%)
		HEAT repeat	272..290	CDD:293787	16/17 (94%)
		HEAT repeat	302..331	CDD:293787	28/28 (100%)
		BLVR	687..840	CDD:283923	57/158 (36%)

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C165152617
Domainoid	1	1.000	805	1.000	Domainoid score	I72
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	984	1.000	Inparanoid score	I310
Isobase	0	0.000	Not matched by this tool.
OMA	1	1.010	-	-		QHG52588
OrthoDB	1	1.010	-	-		D163216at33208
OrthoFinder	1	1.000	-	-		FOG0005167
OrthoInspector	1	1.000	-	-		oto89116
orthoMCL	1	0.900	-	-		OOG6_102126
Panther	1	1.100	-	-	LDO	PTHR22781
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R64
SonicParanoid	1	1.000	-	-		X3686
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	1	0.960	-	-
User_Submission	0	0.000	Not matched by this tool.
	14	13.900