DRSC/TRiP Functional Genomics Resources

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back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits


Protein Alignment TOP3B and TOP3

DIOPT Version :10

Sequence 1:NP_003926.1 Gene:TOP3B / 8940 HGNCID:11993 Length:862 Species:Homo sapiens
Sequence 2:NP_013335.1 Gene:TOP3 / 850935 SGDID:S000004224 Length:656 Species:Saccharomyces cerevisiae


Alignment Length:645 Identity:221/645 - (34%)
Similarity:316/645 - (48%) Gaps:65/645 - (10%)


- Green bases have known domain annotations that are detailed below.


Human     4 VLMVAEKPSLAQSIAKILSRGSLSSHKGLNGACSVHEYTGTFAGQP-------VRFKMTSVCGHV 61
            ||.||||.|:|:::::||..|..:|..  :|...|..|...|:|.|       ....||||.||:
Yeast     3 VLCVAEKNSIAKAVSQILGGGRSTSRD--SGYMYVKNYDFMFSGFPFARNGANCEVTMTSVAGHL 65

Human    62 MTLDFLGKYNKWDKVDPAELFSQAPTEKKEANPKLNMVKFLQVEGRGCDYIVLWLDCDKEGENIC 126
            ..:||....:.|.|....||| .||..:...|.:..:...::.|.|..||:::|.|||:|||.|.
Yeast    66 TGIDFSHDSHGWGKCAIQELF-DAPLNEIMNNNQKKIASNIKREARNADYLMIWTDCDREGEYIG 129

Human   127 FEVLDAVLPVMNKAHGGEK-----TVFRARFSSITDTDICNAMACLGEPDHNEALSVDARQELDL 186
            :|       :..:|..|.:     .|:||.||.:....|.||.......|.....:|..|.|:||
Yeast   130 WE-------IWQEAKRGNRLIQNDQVYRAVFSHLERQHILNAARNPSRLDMKSVHAVGTRIEIDL 187

Human   187 RIGCAFTRFQTKYFQGKYGDL----------------DSSLISFGPCQTPTLGFCVERHDKIQSF 235
            |.|..|||..|:..:.|..:.                ||.::|:|.||.|||||.|:|.::|::|
Yeast   188 RAGVTFTRLLTETLRNKLRNQATMTKDGAKHRGGNKNDSQVVSYGTCQFPTLGFVVDRFERIRNF 252

Human   236 KPETYWVLQAKV-NTDKDRSLLLDWDRVRVFDREIAQMFLNMTKLE---KEAQVEATSRKEKAKQ 296
            .||.:|.:|..| |.|...:....|||..:||| ::.:....|.:|   ..|||.....|...|.
Yeast   253 VPEEFWYIQLVVENKDNGGTTTFQWDRGHLFDR-LSVLTFYETCIETAGNVAQVVDLKSKPTTKY 316

Human   297 RPLALNTVEMLRVASSSLGMGPQHAMQTAERLYTQGYISYPRTETTHYPENFDLKGSLRQQA--- 358
            |||.|.|||:.:..:..|.:..:.::..||:||.:|:||||||||..:|...|||..:.:||   
Yeast   317 RPLPLTTVELQKNCARYLRLNAKQSLDAAEKLYQKGFISYPRTETDTFPHAMDLKSLVEKQAQLD 381

Human   359 -----NHPYWADTVKRLL----AEGINR---PRKG-HDAGDHPPITPMKS-ATEAELGGDAWRLY 409
                 ....||.....||    ....|:   ||.| ||...||||.|:.| ..||.:.....|:|
Yeast   382 QLAAGGRTAWASYAASLLQPENTSNNNKFKFPRSGSHDDKAHPPIHPIVSLGPEANVSPVERRVY 446

Human   410 EYITRHFIATVSHDCKYLQSTISFRIGPELFTCSGKTVLSPGFTEVMPWQSVPLEESLPTCQRGD 474
            ||:.|||:|..|.|.|....|:......|.|:.||..||...|.:|.||......:.||..:...
Yeast   447 EYVARHFLACCSEDAKGQSMTLVLDWAVERFSASGLVVLERNFLDVYPWARWETTKQLPRLEMNA 511

Human   475 AFPVGEVKMLEKQTNPPDYLTEAELITLMEKHGIGTDASIPVHINNICQRNYVTVES-GRR--LK 536
            ...:.:.:|....|.||..:||:|||.||:.:||||||:|..||:.|..||||..|. |:.  |:
Yeast   512 LVDIAKAEMKAGTTAPPKPMTESELILLMDTNGIGTDATIAEHIDKIQVRNYVRSEKVGKETYLQ 576

Human   537 PTNLGIVLVHGYYKIDAE--LVLPTIRSAVEKQLNLIAQGKADYRQVLGHTLDVFKRKFH 594
            ||.||:.||||:..|..|  ...|..|..:|:.|..|.:|.|....|:...::.:::.:|
Yeast   577 PTTLGVSLVHGFEAIGLEDSFAKPFQRREMEQDLKKICEGHASKTDVVKDIVEKYRKYWH 636

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
TOP3BNP_003926.1 TOPRIM_TopoIA_TopoIII 3..167 CDD:173782 57/174 (33%)
TOP1Ac 172..593 CDD:238110 162/462 (35%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 821..854
TOP3NP_013335.1 TOPRIM_TopoIA_TopoIII 2..168 CDD:173782 57/174 (33%)
TOP1Ac 173..635 CDD:238110 162/462 (35%)
Blue background indicates that the domain is not in the aligned region.

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