Protein Alignment TOP3B and top-3B

DIOPT Version :10

• Sequence 1: NP_003926.1
• Gene: TOP3B / 8940
• HGNCID: 11993
• Length: 862
• Species: Homo sapiens
• Sequence 2: NP_001254381.1
• Gene: top-3B / 174978
• WormBaseID: WBGene00012995
• Length: 869
• Species: Caenorhabditis elegans
• Alignment Length: 867
• Identity: 467/867 - (53%)
• Similarity: 586/867 - (67%)
• Gaps: 33/867 - (3%)

Human     3 TVLMVAEKPSLAQSIAKILSRGSLSSHKGLNGACSVHEYTGTFAGQPVRFKMTSVCGHVMTLDFL 67
            |||||||||.||.|||.:||.|.....||.||.|||.||.|.|.|:..|||:||.|||||:|||.
 Worm     4 TVLMVAEKPLLADSIANLLSNGQAKKRKGWNGVCSVSEYDGQFNGRAARFKVTSTCGHVMSLDFP 68

Human    68 GKYNKWDKVDPAELFSQAPTEKKEANPKLNMVKFLQVEGRGCDYIVLWLDCDKEGENICFEVLDA 132
            .|:|.|::||||||:| |||::.|||||:.|.:||..|.:..|::|||||||||||||||||:||
 Worm    69 PKFNNWERVDPAELYS-APTQRIEANPKMKMNEFLASEAKNADFLVLWLDCDKEGENICFEVIDA 132

Human   133 VLPVMNK-AHGGEKTVFRARFSSITDTDICNAMACLGEPDHNEALSVDARQELDLRIGCAFTRFQ 196
            |...|.| .......|:||.||:||:.||..||..||.||.|.:.||||||||||||||:|||||
 Worm   133 VKCAMFKNRQDFMSDVYRAHFSAITEKDIKAAMRNLGRPDQNMSHSVDARQELDLRIGCSFTRFQ 197

Human   197 TKYFQGKYGDLDSSLISFGPCQTPTLGFCVERHDKIQSFKPETYWVLQAKVNTDKDRSLLL-DWD 260
            ||:||||||||||::||:||||||||||||.|||:|..||||.||||:....|..|..:.. :|.
 Worm   198 TKFFQGKYGDLDSNVISYGPCQTPTLGFCVTRHDQIVQFKPEQYWVLKTNFTTSDDGQIFSPEWQ 262

Human   261 RVRVFDREIAQMFLNMTKLEKEAQVEATSRKEKAKQRPLALNTVEMLRVASSSLGMGPQHAMQTA 325
            |.|:||.|:|::|::..|......|...|:||..|:||.||||||::|||||||||.|...|..|
 Worm   263 RGRIFDAEVARVFVDRIKKCHTGLVLDVSKKEARKERPCALNTVELMRVASSSLGMSPSTTMHVA 327

Human   326 ERLYTQGYISYPRTETTHYPENFDLKGSLRQQANHPYWADTVKRLLAEGINRPRKGHDAGDHPPI 390
            |.|||||||||||||||.|..||||.|:|:..|....|...|.::||:||.||:.|.|.||||||
 Worm   328 EALYTQGYISYPRTETTAYSANFDLTGTLKILAGDRKWGSVVSQVLADGIKRPKSGVDKGDHPPI 392

Human   391 TPMKSATEAELGGDAWRLYEYITRHFIATVSHDCKYLQSTISFRIGPELFTCSGKTVLSPGFTEV 455
            |||: .....|.||..|:|||:::||:||:...|.|..:|:....|.|.||..||.|:.||||.|
 Worm   393 TPMR-PNHGGLSGDMSRIYEYVSQHFVATLMKQCVYEVTTVKMSCGDEQFTLQGKNVVEPGFTAV 456

Human   456 MPWQSVPLEESLPTC--QRGDAFPVGEVKMLEKQTNPPDYLTEAELITLMEKHGIGTDASIPVHI 518
            |||.||..|.|:|..  |.|....:...::..::|.||.||||||||||||||||||||||||||
 Worm   457 MPWLSVEEECSVPKSLQQIGAKIELQNAEIQARETTPPGYLTEAELITLMEKHGIGTDASIPVHI 521

Human   519 NNICQRNYVTVESGRRLKPTNLGIVLVHGYYKIDAELVLPTIRSAVEKQLNLIAQGKADYRQVLG 583
            |.|.|||||||||||||.||.||..||.||:|:|.||||||:|:.:|:||||:|.|||||..|..
 Worm   522 NTITQRNYVTVESGRRLVPTRLGQCLVRGYWKVDPELVLPTMRAELEEQLNLVASGKADYLDVKN 586

Human   584 HTLDVFKRKFHYFVDSIAGMDELMEVSFSPLAATGKPLSRCGKCHRFMKYIQAKPSRLHCSHCDE 648
            |.|.:|:.||.|||.:|..:|.|.|.||:.|:.||||.||||||.|:||.:|.||.||:|..|.|
 Worm   587 HALKMFEMKFQYFVTNIPAVDTLFEASFTTLSDTGKPFSRCGKCRRYMKLVQTKPQRLYCPTCQE 651

Human   649 TYTLP--QNGTIKLYKELRCPLDDFELVLWS--SGSRGKSYPLCPYCYNHPPFRDMKKGMGCNEC 709
            ||.:|  ::|.:|:..:.:||||||:::|:.  .|...:::.|||:|:|:|||..|.:|.||:.|
 Worm   652 TYAVPNFKDGVLKVIGDHKCPLDDFDVILYQGPGGKLARTFTLCPFCFNNPPFEKMPQGAGCDTC 716

Human   710 THPSCQHSLSMLGIGQCVECESGVLVLDPTSGPKWKVACNKCNVVAHCFENAHRVRV-SADTCSV 773
            .|||||:|:|..|:..|::...||::||..|.|||::.||||..|...||.|.:|:| |..:|..
 Worm   717 VHPSCQYSISSNGVCGCLQDCGGVMLLDTQSHPKWRMTCNKCPSVVGLFEGAIKVKVDSTRSCEQ 781

Human   774 CEAALLDVDFNKAKSPLPG----DETQHMGCVFCDPV--FQELVELKHAASCH---------PMH 823
            |:|..:..:| |..|..||    :.:.:.||:|||.:  :.:.:.|.||....         |..
 Worm   782 CDAQFIKAEF-KPNSGKPGAIEYESSSYEGCIFCDAMKKYPDAINLNHAYLTEESRQRNTQAPRR 845

Human   824 RGGPGR------RQGRGRGRAR 839
            .||.||      |.||||||.|
 Worm   846 GGGGGRGRGGRGRGGRGRGRGR 867

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
TOP3B	NP_003926.1	TOPRIM_TopoIA_TopoIII	3..167	CDD:173782	98/164 (60%)
		TOP1Ac	172..593	CDD:238110	249/423 (59%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	821..854		13/25 (52%)
top-3B	NP_001254381.1	PRK07219	4..739	CDD:235971	419/736 (57%)