Protein Alignment CCND2 and CycA

DIOPT Version :10

• Sequence 1: NP_001750.1
• Gene: CCND2 / 894
• HGNCID: 1583
• Length: 289
• Species: Homo sapiens
• Sequence 2: NP_524030.2
• Gene: CycA / 39340
• FlyBaseID: FBgn0000404
• Length: 491
• Species: Drosophila melanogaster
• Alignment Length: 294
• Identity: 80/294 - (27%)
• Similarity: 134/294 - (45%)
• Gaps: 62/294 - (21%)

Human    22 RDDR------------VLQNLLTIEERYLPQCSYFKCVQKDIQPYMRRMVATWMLEVCEEQKCEE 74
            |:||            :|:.....|:::.|:..|.: .||||...||.::..|::||.||.|.:.
  Fly   191 RNDRQRFLEVVQYQMDILEYFRESEKKHRPKPLYMR-RQKDISHNMRSILIDWLVEVSEEYKLDT 254

Human    75 EVFPLAMNYLDRFLAGVPTPKSHLQLLGAVCMFLASKLKETSPLTAEKLCIYTDNSIKPQELLEW 139
            |...|::.||||||:.:...:|.|||:|...|::|:|.:|..|....:....||:|....::|..
  Fly   255 ETLYLSVFYLDRFLSQMAVVRSKLQLVGTAAMYIAAKYEEIYPPEVGEFVFLTDDSYTKAQVLRM 319

Human   140 ELVVLGKLKWNLAAVTPHDFIE--HILRKLPQQRE-------KLSLIRKHAQTFIALCATDFKFA 195
            |.|:|..|.::|...|.:.||.  .:|..:|::.:       :|||:  ..:|::
  Fly   320 EQVILKILSFDLCTPTAYVFINTYAVLCDMPEKLKYMTLYISELSLM--EGETYL---------- 372

Human   196 MYPPSMIATGSVGAA--ICGLQQDEEVSSLTCDALTELLAKITNTDVDCLKA-----CQEQIEAV 253
            .|.||::::.||..|  |.|::.           .|..|.:||...::.||.     |.....|.
  Fly   373 QYLPSLMSSASVALARHILGMEM-----------WTPRLEEITTYKLEDLKTVVLHLCHTHKTAK 426

Human   254 LLNSLQQYRQDQRDGSK----------SEDELDQ 277
            .||:.....:..||..|          |:|:.||
  Fly   427 ELNTQAMREKYNRDTYKKVAMMESVEMSKDDFDQ 460

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
CCND2	NP_001750.1	CYCLIN_SF	1..150	CDD:477360	45/139 (32%)
		CYCLIN_CCND2_rpt2	155..259	CDD:410280	27/119 (23%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	264..289		7/24 (29%)
CycA	NP_524030.2	CYCLIN_CCNA_rpt1	202..329	CDD:410208	42/127 (33%)
		Cyclin_C	334..450	CDD:397230	30/138 (22%)