DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment PHOX2B and Drgx

DIOPT Version :9

Sequence 1:	NP_003915.2	Gene:	PHOX2B / 8929	HGNCID:	9143	Length:	314	Species:	Homo sapiens
Sequence 2:	NP_001097075.2	Gene:	Drgx / 5740176	FlyBaseID:	FBgn0085369	Length:	587	Species:	Drosophila melanogaster

Alignment Length:	356	Identity:	116/356 - (32%)
Similarity:	151/356 - (42%)	Gaps:	127/356 - (35%)

- Green bases have known domain annotations that are detailed below.

Human    58 PSLTPGSCS-----LGTLRDHQSSPYAAV-PYKLFTDHGGLNE----KRKQRRIRTTFTSAQLKE 112
            |:|.|  |.     |.|| |:   |:||. ||..::.|..:::    :|||||.|||||..||:|
  Fly     8 PALHP--CGPHPPRLPTL-DY---PFAATHPYTSYSYHPAIHDETFVRRKQRRNRTTFTLQQLEE 66

Human   113 LERVFAETHYPDIYTREELALKIDLTEARVQVWFQNRRAKFRKQERAAAAAAAAAKNGSSGKKSD 177
            ||..||:|||||::|||:||:||:||||||||||||||||:||.|| ........:||.|
  Fly    67 LETAFAQTHYPDVFTREDLAMKINLTEARVQVWFQNRRAKWRKAER-LKDEQRKRENGES----- 125

Human   178 SSRDDESKEAKSTDPDSTGGPGPNPNPTP------SCGANG------------------GGG--- 215
            ||..|:..:::.:.||.||....:.:..|      |..|||                  |||
  Fly   126 SSSLDKLHDSRESSPDITGEIDDDMDDLPPRQRSHSPLANGQMEQQHSHSHSHSHSRSPGGGMHL 190

Human   216 ------------------------------GGPSPAG-----------APGAAGPGGPG------ 233
                                          |.|||:|           ..|..||..|.
  Fly   191 DSSDNERPLSSNQLTATPHSASQSLGSISAGSPSPSGMHREREHTPLVGGGGQGPSSPSNSRNTD 255

Human   234 -----GEP---GKGGAAAAAAAAAAAA--------------AAAAAAAAGGLAAAGGPGQGWAPG 276
                 |.|   ..|...||::..:|::              ::||||||.|....|..|.|
  Fly   256 SPIEVGGPMSLTTGSRMAASSNNSASSTPTPTTPHAPQMPHSSAAAAAAFGSHIFGNFGGG---- 316

Human   277 PGPITSIPDSLGGPFASVLSSLQRPNGAKAA 307
                ::..||..| |..|||.......|.||
  Fly   317 ----SNASDSNCG-FRPVLSEQSAVAAAAAA 342

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
PHOX2B	NP_003915.2	Homeobox	102..155	CDD:395001	40/52 (77%)
PHOX2B	NP_003915.2	polyalanine repeat	241..260		7/32 (22%)
Drgx	NP_001097075.2	Homeobox	56..108	CDD:278475	40/51 (78%)
Drgx	NP_001097075.2	OAR	428..445	CDD:281777
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0000011
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	2	1.910