DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment PHOX2B and hbn

DIOPT Version :9

Sequence 1:	NP_003915.2	Gene:	PHOX2B / 8929	HGNCID:	9143	Length:	314	Species:	Homo sapiens
Sequence 2:	NP_788420.1	Gene:	hbn / 47894	FlyBaseID:	FBgn0008636	Length:	409	Species:	Drosophila melanogaster

Alignment Length:	301	Identity:	91/301 - (30%)
Similarity:	114/301 - (37%)	Gaps:	121/301 - (40%)

- Green bases have known domain annotations that are detailed below.

Human    88 DHGGLNEKRKQRRIRTTFTSAQLKELERVFAETHYPDIYTREELALKIDLTEARVQVWFQNRRAK 152
            |...:...||.||.|||||:.||.:|||.|.:|.|||::|||:||:::||:||||||||||||||
  Fly   143 DLSDMERPRKVRRSRTTFTTFQLHQLERAFEKTQYPDVFTREDLAMRLDLSEARVQVWFQNRRAK 207

Human   153 FRKQERAAAAAAAAAKNGSSGKKSDSSRDDESKEAKSTDPDSTGGPGPNPNPTPSCGANGGGGGG 217
            :||:|                              |..:.|..|...|..             |.
  Fly   208 WRKRE------------------------------KFMNQDKAGYLLPEQ-------------GL 229

Human   218 PS-PAGAPGAAGPGGPGGEPGK----------------GGAAAAAAA------------------ 247
            |. |.|.|  ..|.|..|.||.                ..||||||.
  Fly   230 PEFPLGIP--LPPHGLPGHPGSMQSEFWPPHFALHQHFNPAAAAAAGLLPQHLMAPHYKLPNFHT 292

Human   248 ---------------AAAAAAAAAAAAAG---------GLAAA---------GGPGQG--WAPGP 277
                           .|.||||||||:||         ||:|.         ..|.:.  ..|.|
  Fly   293 LLSQYMGLSNLNGIFGAGAAAAAAAASAGYPQNLSLHAGLSAMSQVSPPCSNSSPRESPKLVPHP 357

Human   278 GPITSIPDSLGGPFASVL------SSLQRPNGAKAALVKSS 312
            .|..:.|.:.|.....:|      ::.|.||.|..|...:|
  Fly   358 TPPHATPPAGGNGGGGLLTGGLISTAAQSPNSAAGASSNAS 398

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
PHOX2B	NP_003915.2	Homeobox	102..155	CDD:395001	36/52 (69%)
PHOX2B	NP_003915.2	polyalanine repeat	241..260		15/51 (29%)
hbn	NP_788420.1	Homeobox	156..209	CDD:278475	36/52 (69%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	127	1.000	Inparanoid score	I4690
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0000011
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	3	2.960