Protein Alignment PHOX2B and hbn

DIOPT Version :10

• Sequence 1: NP_003915.2
• Gene: PHOX2B / 8929
• HGNCID: 9143
• Length: 314
• Species: Homo sapiens
• Sequence 2: NP_788420.1
• Gene: hbn / 47894
• FlyBaseID: FBgn0008636
• Length: 409
• Species: Drosophila melanogaster
• Alignment Length: 301
• Identity: 91/301 - (30%)
• Similarity: 114/301 - (37%)
• Gaps: 121/301 - (40%)

Human    88 DHGGLNEKRKQRRIRTTFTSAQLKELERVFAETHYPDIYTREELALKIDLTEARVQVWFQNRRAK 152
            |...:...||.||.|||||:.||.:|||.|.:|.|||::|||:||:::||:||||||||||||||
  Fly   143 DLSDMERPRKVRRSRTTFTTFQLHQLERAFEKTQYPDVFTREDLAMRLDLSEARVQVWFQNRRAK 207

Human   153 FRKQERAAAAAAAAAKNGSSGKKSDSSRDDESKEAKSTDPDSTGGPGPNPNPTPSCGANGGGGGG 217
            :||:|                              |..:.|..|...|..             |.
  Fly   208 WRKRE------------------------------KFMNQDKAGYLLPEQ-------------GL 229

Human   218 PS-PAGAPGAAGPGGPGGEPGK----------------GGAAAAAAA------------------ 247
            |. |.|.|  ..|.|..|.||.                ..||||||.
  Fly   230 PEFPLGIP--LPPHGLPGHPGSMQSEFWPPHFALHQHFNPAAAAAAGLLPQHLMAPHYKLPNFHT 292

Human   248 ---------------AAAAAAAAAAAAAG---------GLAAA---------GGPGQG--WAPGP 277
                           .|.||||||||:||         ||:|.         ..|.:.  ..|.|
  Fly   293 LLSQYMGLSNLNGIFGAGAAAAAAAASAGYPQNLSLHAGLSAMSQVSPPCSNSSPRESPKLVPHP 357

Human   278 GPITSIPDSLGGPFASVL------SSLQRPNGAKAALVKSS 312
            .|..:.|.:.|.....:|      ::.|.||.|..|...:|
  Fly   358 TPPHATPPAGGNGGGGLLTGGLISTAAQSPNSAAGASSNAS 398

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
PHOX2B	NP_003915.2	Homeodomain	99..155	CDD:459649	38/55 (69%)
		polyalanine repeat	241..260		15/51 (29%)
hbn	NP_788420.1	Homeodomain	154..210	CDD:459649	38/55 (69%)