Protein Alignment HERC1 and Rcc1

DIOPT Version :9

• Sequence 1: XP_016878188.1
• Gene: HERC1 / 8925
• HGNCID: 4867
• Length: 4909
• Species: Homo sapiens
• Sequence 2: NP_523943.1
• Gene: Rcc1 / 38669
• FlyBaseID: FBgn0002638
• Length: 547
• Species: Drosophila melanogaster
• Alignment Length: 417
• Identity: 101/417 - (24%)
• Similarity: 167/417 - (40%)
• Gaps: 90/417 - (21%)

Human  4094 GTVLACGEGSYGRLGQGNSDDLHVLTVISALQGFVVTQLVTSCGSDGHSMALTESGEVFSWGDGD 4158
            |.||.||.|..|:||.|  :|:.....:|.:.|  :...|.......|::.||:||:::|:|..|
  Fly    42 GNVLVCGNGDVGQLGLG--EDILERKRLSPVAG--IPDAVDISAGGMHNLVLTKSGDIYSFGCND 102

Human  4159 YGKLGHGNSD--RQRRPRQIEALQGEEVVQMSCGFKHSAVVTSDGKLFTFGN--GDYGRLGLGNT 4219
            .|.||...|:  .:.:|..|: |.|:.:. :|.|..|||.:..||::|.:|:  ..:|.:||...
  Fly   103 EGALGRDTSEDGSESKPDLID-LPGKALC-ISAGDSHSACLLEDGRVFAWGSFRDSHGNMGLTID 165

Human  4220 SNKKLPERVTALEGYQIGQVACGLNHTLAVSADGSMVWAFGDGDYGKLGLGNSTA---------- 4274
            .||:.|  :..:||.....:|.|.:|.:.::..|. |:..|..:.|:||..:..:
  Fly   166 GNKRTP--IDLMEGTVCCSIASGADHLVILTTAGK-VFTVGCAEQGQLGRLSERSISGEGRRGKR 227

Human  4275 -----------KSSP---------------QKIDVLCGIG------------------------- 4288
                       ::.|               .:..|:...|
  Fly   228 DLLRPTQLIITRAKPFEAIWATNYCTFMRESQTQVIWATGLNNFKQLAHETKGKEFALTPIKTEL 292

Human  4289 --IKKVACGTQFSVALTKDGHVYTFGQDRLIGLPEGRARN-HNRPQQIPVLAGVIIEDVAVGAEH 4350
              |:.:|.|...:|.||.|......|:.....|..|..:: ..:|..:..|...|: .|..|...
  Fly   293 KDIRHIAGGQHHTVILTTDLKCSVVGRPEYGRLGLGDVKDVVEKPTIVKKLTEKIV-SVGCGEVC 356

Human  4351 TLALASNGDVYAWGSNSEGQLGLGHTNHVREPTLVT--GLQGKNVRQISAGRCHSAAWTAPP--- 4410
            :.|:..:|.:|:|||....|||:|..:...||.:|.  ..|||::...|.|..|:.......
  Fly   357 SYAVTIDGKLYSWGSGVNNQLGVGDGDDELEPIVVVSKNTQGKHMLLASGGGQHAIFLVKADKQD 421

Human  4411 ----VPPRAPGVSVPLQLGLPDTVPPQ 4433
                ||.:..|.|   .:...|..|||
  Fly   422 QKENVPVKVSGSS---SISKKDKTPPQ 445

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
HERC1	XP_016878188.1	None
Rcc1	NP_523943.1	RCC1	42..89	CDD:278826	15/50 (30%)
		RCC1	92..141	CDD:278826	18/50 (36%)
		RCC1_2	131..158	CDD:290274	9/26 (35%)
		RCC1	144..193	CDD:278826	15/50 (30%)
		RCC1_2	182..209	CDD:290274	6/27 (22%)
		RCC1	363..414	CDD:278826	18/50 (36%)

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C165143342
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG5184
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D1062377at2759
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	4	3.750