Protein Alignment HERC2 and ATS1

DIOPT Version :9

• Sequence 1: NP_004658.3
• Gene: HERC2 / 8924
• HGNCID: 4868
• Length: 4834
• Species: Homo sapiens
• Sequence 2: NP_009382.2
• Gene: ATS1 / 851213
• SGDID: S000000018
• Length: 333
• Species: Saccharomyces cerevisiae
• Alignment Length: 376
• Identity: 84/376 - (22%)
• Similarity: 129/376 - (34%)
• Gaps: 114/376 - (30%)

Human  4006 LYATGYGAGGRLGIGGTESVSTPTLLESI---QHVFIKKVAVNSGGKHCLALSSEGEVYSWGEAE 4067
            :||.|.....:||:|..|.:.||.  .|:   ....::|:|  .||.|.:.|:::|.:...|:..
Yeast     4 VYAFGSNGQRQLGLGHDEDMDTPQ--RSVPGDDGAIVRKIA--CGGNHSVMLTNDGNLVGCGDNR 64

Human  4068 DGKLGHGNRSPCDRPRVIESLRGIE----VVDVAAGGAHSACVTAAGDLYTWGKGRYGRLGHSDS 4128
            .|:|     ......|.:...|.:|    |||||.|...:..|.|.|.::..|.|.|
Yeast    65 RGEL-----DSAQALRQVHDWRPVEVPAPVVDVACGWDTTVIVDADGRVWQRGGGCY-------- 116

Human  4129 EDQLKPKLVEALQGH--------RVVDIACGSGDAQTLCLTDDDTVWSWGDGDYGKLGRGGSDGC 4185
                     |..|.|        |:....|    .|...:.....|:.||.....:|....|...
Yeast   117 ---------EFTQQHVPLNSNDERIAVYGC----FQNFVVVQGTRVYGWGSNTKCQLQEPKSRSL 168

Human  4186 KVPMKIDSLTGLGVVKVECGSQFSVALTKSG-------------------------------AVY 4219
            |.|:.:.....:.|..|..|..|.|.:.:.|                               :::
Yeast   169 KEPVLVYDTGSVAVDYVAMGKDFMVIVDEGGRIVHASGRLPTGFELKQQQKRHNLVVLCMWTSIH 233

Human  4220 TW----------GKGDYHRLGHGSDDHVRRPRQVQGLQGKKVIAIATGSLHCVCCTEDGE----- 4269
            .|          |:|.:.:|  ...:.:..|          ::.:||||.|.:..|.:.|
Yeast   234 LWNARLNTVESFGRGTHSQL--FPQERLDFP----------IVGVATGSEHGILTTANQEGKSHC 286

Human  4270 --VYTWGDNDEGQLG--DGTTNAIQRPRLVAALQGKKVNRVACGSAHTLAW 4316
              ||.||..:.|..|  .|:...:|   ||....||.  ||..|.|.|  |
Yeast   287 YNVYCWGWGEHGNCGPQKGSQPGLQ---LVGQYSGKP--RVFGGCATT--W 330

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
HERC2	NP_004658.3	Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	50..88
		RCC1 1-1. /evidence=ECO:0000255|PROSITE-ProRule:PRU00235, ECO:0000269|Ref.21	415..461
		RCC1 1-2. /evidence=ECO:0000255|PROSITE-ProRule:PRU00235, ECO:0000269|Ref.21	462..512
		RCC1 1-3. /evidence=ECO:0000255|PROSITE-ProRule:PRU00235, ECO:0000269|Ref.21	513..568
		RCC1	514..566	CDD:278826
		RCC1 1-4. /evidence=ECO:0000255|PROSITE-ProRule:PRU00235, ECO:0000269|Ref.21	569..620
		RCC1	569..620	CDD:278826
		RCC1 1-5. /evidence=ECO:0000255|PROSITE-ProRule:PRU00235, ECO:0000269|Ref.21	623..674
		RCC1	623..672	CDD:278826
		RCC1 1-6. /evidence=ECO:0000255|PROSITE-ProRule:PRU00235, ECO:0000269|Ref.21	675..726
		RCC1	675..724	CDD:278826
		RCC1 1-7. /evidence=ECO:0000255|PROSITE-ProRule:PRU00235, ECO:0000269|Ref.21	728..778
		Cyt-b5	1209..1282	CDD:278597
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	1555..1575
		MIB_HERC2	1870..1929	CDD:284184
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	1933..1958
		UBA_HERC2	2460..2507	CDD:270585
		Cul7	2554..2631	CDD:288381
		ZZ_HERC2	2706..2750	CDD:239084
		APC10-HERC2	2765..2910	CDD:176485
		RCC1 2-1. /evidence=ECO:0000255|PROSITE-ProRule:PRU00235, ECO:0000269|Ref.21	2958..3009
		RCC1	2960..3007	CDD:278826
		RCC1 2-2. /evidence=ECO:0000255|PROSITE-ProRule:PRU00235, ECO:0000269|Ref.21	3010..3064
		RCC1	3010..3062	CDD:278826
		RCC1 2-3. /evidence=ECO:0000255|PROSITE-ProRule:PRU00235, ECO:0000269|Ref.21	3065..3116
		RCC1	3065..3114	CDD:278826
		RCC1	3117..3168	CDD:278826
		RCC1 2-4. /evidence=ECO:0000255|PROSITE-ProRule:PRU00235, ECO:0000269|Ref.21	3118..3168
		RCC1 2-5. /evidence=ECO:0000255|PROSITE-ProRule:PRU00235, ECO:0000269|Ref.21	3171..3222
		RCC1	3171..3220	CDD:278826
		RCC1	3223..3272	CDD:278826
		RCC1 2-6. /evidence=ECO:0000255|PROSITE-ProRule:PRU00235, ECO:0000269|Ref.21	3224..3274
		RCC1 2-7. /evidence=ECO:0000255|PROSITE-ProRule:PRU00235, ECO:0000269|Ref.21	3275..3326
		RCC1	3275..3324	CDD:278826
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	3602..3629
		RCC1 3-1. /evidence=ECO:0000255|PROSITE-ProRule:PRU00235, ECO:0000269|Ref.21	3951..4002
		RCC1 3-2. /evidence=ECO:0000255|PROSITE-ProRule:PRU00235, ECO:0000269|Ref.21	4004..4056		16/52 (31%)
		RCC1_2	4039..4069	CDD:290274	8/29 (28%)
		RCC1	4057..4106	CDD:278826	13/52 (25%)
		RCC1 3-3. /evidence=ECO:0000255|PROSITE-ProRule:PRU00235, ECO:0000269|Ref.21	4058..4108		14/53 (26%)
		RCC1 3-4. /evidence=ECO:0000255|PROSITE-ProRule:PRU00235, ECO:0000269|Ref.21	4110..4162		10/59 (17%)
		RCC1	4110..4160	CDD:278826	10/57 (18%)
		RCC1	4163..4212	CDD:278826	12/48 (25%)
		RCC1 3-5. /evidence=ECO:0000255|PROSITE-ProRule:PRU00235, ECO:0000269|Ref.21	4164..4214		12/49 (24%)
		RCC1	4215..4263	CDD:278826	11/88 (13%)
		RCC1 3-6. /evidence=ECO:0000255|PROSITE-ProRule:PRU00235, ECO:0000269|Ref.21	4216..4266		11/90 (12%)
		RCC1	4267..4316	CDD:278826	18/57 (32%)
		RCC1 3-7. /evidence=ECO:0000255|PROSITE-ProRule:PRU00235, ECO:0000269|Ref.21	4268..4318		19/58 (33%)
		HECTc	4421..4792	CDD:238033
		HECTc	4464..4790	CDD:214523
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	4804..4834
ATS1	NP_009382.2	ATS1	1..333	CDD:227511	84/376 (22%)

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG5184
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	2	1.810