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Protein Alignment HERC2 and Rcc1

DIOPT Version :9

Sequence 1:	NP_004658.3	Gene:	HERC2 / 8924	HGNCID:	4868	Length:	4834	Species:	Homo sapiens
Sequence 2:	NP_523943.1	Gene:	Rcc1 / 38669	FlyBaseID:	FBgn0002638	Length:	547	Species:	Drosophila melanogaster

Alignment Length:	489	Identity:	119/489 - (24%)
Similarity:	182/489 - (37%)	Gaps:	139/489 - (28%)

- Green bases have known domain annotations that are detailed below.

Human  3008 TVEGKVYACGEATNGRLGLGISSGTVPIPRQITALSSYVVKKVAVHSGGRHATALTVDGKVFSWG 3072
            ||.|.|..||....|:||||...    :.|:..:..:.:...|.:.:||.|...||..|.::|:|
  Fly    39 TVLGNVLVCGNGDVGQLGLGEDI----LERKRLSPVAGIPDAVDISAGGMHNLVLTKSGDIYSFG 99

Human  3073 EGDDGKLGHFSRMNC--DKPRLIEALKTKRIRDIACGSSHSAALTSSGELYTWG--LGEYGRLG- 3132
            ..|:|.||..:..:.  .||.||: |..|.: .|:.|.||||.|...|.::.||  ...:|.:|
  Fly   100 CNDEGALGRDTSEDGSESKPDLID-LPGKAL-CISAGDSHSACLLEDGRVFAWGSFRDSHGNMGL 162

Human  3133 --HGDNTTQLKPKMVKVLLGHRVIQVACGSRDAQTLALTDEGLVFSWGDGDFGKLGR-------- 3187
              .|:..|.     :.::.|.....:|.|:  ...:.||..|.||:.|..:.|:|||
  Fly   163 TIDGNKRTP-----IDLMEGTVCCSIASGA--DHLVILTTAGKVFTVGCAEQGQLGRLSERSISG 220

Human  3188 GGSEG--------------------------C-----------------NIPQNIERLNG----- 3204
            .|..|                          |                 |..|......|
  Fly   221 EGRRGKRDLLRPTQLIITRAKPFEAIWATNYCTFMRESQTQVIWATGLNNFKQLAHETKGKEFAL 285

Human  3205 -------QGVCQIECGAQFSLALT---KSGVVWTWGKGDYFRLGHG--SDVHVRKPQVVEGLRGK 3257
                   :.:..|..|...::.||   |..||   |:.:|.|||.|  .|| |.||.:|:.|. :
  Fly   286 TPIKTELKDIRHIAGGQHHTVILTTDLKCSVV---GRPEYGRLGLGDVKDV-VEKPTIVKKLT-E 345

Human  3258 KIVHVAVGALHCLAVTDSGQVYAWGDNDHGQQGNGTTTVNRKPTLV--QGLEGQKITRVACGSSH 3320
            |||.|..|.:...|||..|::|:||...:.|.|.|......:|.:|  :..:|:.:...:.|..|
  Fly   346 KIVSVGCGEVCSYAVTIDGKLYSWGSGVNNQLGVGDGDDELEPIVVVSKNTQGKHMLLASGGGQH 410

Human  3321 SVAWTTVDVATPSVHEPVLFQTARDPLGASYL--------------------------GVPSDAD 3359
            ::.....|......:.||...      |:|.:                          .:|:.|.
  Fly   411 AIFLVKADKQDQKENVPVKVS------GSSSISKKDKTPPQDNVDKEAENVDKQEQKENLPAKAS 469

Human  3360 SSAASNKISGASNS------------KPNRPSLA 3381
            :|:..||.....|:            |.|.|:.|
  Fly   470 TSSKKNKTPPQDNADKEAENVDKQEQKENLPAKA 503

Known Domains:

Indicated by green bases in alignment.

Software error:

Illegal division by zero at /www/www.flyrnai.org/docroot/cgi-bin/DRSC_prot_align.pl line 591.

For help, please send mail to the webmaster (ritg@hms.harvard.edu), giving this error message and the time and date of the error.