DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment HERC3 and niki

DIOPT Version :9

Sequence 1:	NP_055421.1	Gene:	HERC3 / 8916	HGNCID:	4876	Length:	1050	Species:	Homo sapiens
Sequence 2:	NP_651293.1	Gene:	niki / 42959	FlyBaseID:	FBgn0045980	Length:	841	Species:	Drosophila melanogaster

Alignment Length:	499	Identity:	121/499 - (24%)
Similarity:	195/499 - (39%)	Gaps:	135/499 - (27%)

- Green bases have known domain annotations that are detailed below.

Human    86 IIHVACGESHSLALSDRGQLFSWGAGSDGQLGLMTTEDSVAVPRLIQKLNQQTILQVSCGNWHCL 150
            |:.||..:||.:.:::.|..::||.|:.|||||...|.....|..::.:....::....|:...:
  Fly   454 IVDVAMSDSHFVVVNEDGSAYAWGEGTHGQLGLTALEAWKHYPSRMESVRNYHVVSACAGDGFTI 518

Human   151 ALAADGQFFTWGKNSHGQLGLGK-EFPSQASPQRVRSLEGIPLAQVAAGGAHSFALSLSGAVFGW 214
            .:...|...:.|.|:|  |.||: |..:..||:.:..|..:.:.|||||..|..|||..|||:.|
  Fly   519 LVTQAGSLLSCGSNAH--LALGQDEQRNYHSPKLIARLADVRVEQVAAGLQHVLALSREGAVYVW 581

Human   215 GMNNAGQLGLSD-EKDRESP-----CHVKLLRTQKVVYISCGEEHTAVLTKSGGVFTFGAGSCGQ 273
            |.:..|.|||.: ::.::.|     .|||    .|...|.||.:.:|||..:|.:...|:....:
  Fly   582 GTSTCGALGLGNYQQQQKFPQKILLSHVK----TKPSKIYCGPDTSAVLFANGELHVCGSNDYNK 642

Human   274 LGHDSMNDEVNPRRVLELMGSEVTQIACGRQHTLAFVPSSGLIYAFGCGARGQLGTGHTCNVKCP 338
            ||. ..:.::...:.::| ..:|||......|:: |:...|.:|..|..|.||.|..|..:|..|
  Fly   643 LGF-QRSAKITAFKKVQL-PHKVTQACFSSTHSV-FLVEGGYVYTMGRNAEGQRGIRHCNSVDHP 704

Human   339 SPVKGYWAAHSGQLSARADRFK-YHIVKQIFSGGDQTFVLCSKYENYSPAVDFRTMNQAHYTSLI 402
            :.|               |..| .:|||...|  ||..::.|:
  Fly   705 TLV---------------DSVKSRYIVKANCS--DQCTIVASE---------------------- 730

Human   403 NDETIAVWRQKLSEHNNANTINGVVQILSSAACWNGSFLEKKIDEHFKTSPKIPGIDLNSTRVLF 467
             |..|.||          .|.||:..| .|..|..|..:         .:|.:. ::|.:....|
  Fly   731 -DNIITVW----------GTRNGLPGI-GSTNCGLGLQI---------CTPNME-LELGNNTAAF 773

Human   468 EKLMNS--QHSMILEQI-----LNSFESCLIPQLSSSPPDVEAMRIYLILPEFPLLQDSKYYITL 525
            ...:.|  :..:|||.:     .:|.|.|                            |..||:.:
  Fly   774 TNFLASVYKSELILEPVDILALFSSKEQC----------------------------DRGYYVQV 810

Human   526 --TIPLAMAILRL--DTNPSKVLDNWWSQVCPKYFMKLVNLYKG 565
              ..|||.::|.|  .|.|                  |::.|:|
  Fly   811 HDVYPLAHSVLVLVDTTTP------------------LISSYEG 836

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
HERC3	NP_055421.1	RCC1 1	1..51
		ATS1	2..331	CDD:227511	74/251 (29%)
		RCC1 2	52..101		5/14 (36%)
		RCC1 3	102..154		12/51 (24%)
		RCC1 4	156..207		19/51 (37%)
		RCC1 5	208..259		20/56 (36%)
		RCC1 6	261..311		10/49 (20%)
		RCC1	313..377	CDD:366085	19/64 (30%)
		RCC1 7	313..366		15/53 (28%)
		HECTc	702..1048	CDD:238033
niki	NP_651293.1	STKc_Nek	104..359	CDD:270855
		S_TKc	105..354	CDD:214567
		ATS1	445..747	CDD:227511	95/352 (27%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D1062377at2759
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	2	1.920