Protein Alignment HERC3 and Nedd4

DIOPT Version :9

• Sequence 1: NP_055421.1
• Gene: HERC3 / 8916
• HGNCID: 4876
• Length: 1050
• Species: Homo sapiens
• Sequence 2: NP_648993.1
• Gene: Nedd4 / 39958
• FlyBaseID: FBgn0259174
• Length: 1007
• Species: Drosophila melanogaster
• Alignment Length: 456
• Identity: 126/456 - (27%)
• Similarity: 210/456 - (46%)
• Gaps: 55/456 - (12%)

Human   606 HVEYDTFYIPEISNLVDIQEDYLMWFLHQAGMKARPSIIQDTVTLCSYPFIFDAQAKTKMLQTDA 670
            |.:...|||...:.....::..|          :.|:|....|     |:..|.:.|.:..::..
  Fly   591 HTDGRVFYIDHNTRTTQWEDPRL----------SNPNIAGQAV-----PYSRDYKQKYEYFKSHI 640

Human   671 ELQMQVAVNGANLQNVFMLLTLEPLLARSPFLVLHVRRNNLVGDALRELSIHSDID-LKKPLKVI 734
            .       ...|:.|.|               .:.:||.:::.|:.|.:|..:..| ||..|.|.
  Fly   641 R-------KPTNVPNKF---------------EIRIRRTSILEDSYRIISSVTKTDLLKTKLWVE 683

Human   735 FDGEEAVDAGGVTKEFFLLLLKELLNPIYGMFTY-YQDSNLLWF---SDTCFVEH-NWFHLIGIT 794
            |:||..:|.||:.:|:|.||.||:.||.||:|.| ..|:..|..   |..|..|| ::|..||..
  Fly   684 FEGETGLDYGGLAREWFYLLSKEMFNPYYGLFEYSAMDNYTLQINNGSGLCNEEHLSYFKFIGRI 748

Human   795 CGLAIYNSTVVDLHFPLALYKKLLNVKPGLEDLKELSPTEGRSLQELLDYPGEDVEETFCLNFTI 859
            .|:|:|:..::|..|....||.:|.....|:|::.:......||..:.:.....:|.||||:
  Fly   749 AGMAVYHGKLLDAFFIRPFYKMMLQKPIDLKDMESVDTEYYNSLMWIKENDPRILELTFCLD--- 810

Human   860 CRESYGVIEQKKLIPGGDNVTVCKDNRQEFVDAYVNYVFQISVHEWYTAFSSGFLKVCGGKVLEL 924
             .:.:|...|.:|.|||.|:.|..:|:.|::...:.:.|...|.|..::|..||..:....::::
  Fly   811 -EDVFGQKSQHELKPGGANIDVTNENKDEYIKLVIEWRFVARVKEQMSSFLDGFGSIIPLNLIKI 874

Human   925 FQPSELRAMMVGNSNYNWEELEETAIYKGDYSATHPTVKLFWETFHEFPLEKKKKFLLFLTGSDR 989
            |...||..:|.|..|.:.::..|..:|||||...|..::.||.....|..|.:.:.|.|:||:.|
  Fly   875 FDEHELELLMCGIQNIDVKDWRENTLYKGDYHMNHIIIQWFWRAVLSFSNEMRSRLLQFVTGTSR 939

Human   990 IPIYGMASL-------QIVIQSTASGEEYLPVAHTCYNLLDLPKYSSKEILSARLTQALDNYEGF 1047
            :|:.|...|       ...|:...:...: |.||||:|.||||.|.....|..:|.:|::..:||
  Fly   940 VPMNGFKELYGSNGPQMFTIEKWGTPNNF-PRAHTCFNRLDLPPYEGYLQLKDKLIKAIEGSQGF 1003

Human  1048 S 1048
            :
  Fly  1004 A 1004

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
HERC3	NP_055421.1	RCC1 1	1..51
		ATS1	2..331	CDD:227511
		RCC1 2	52..101
		RCC1 3	102..154
		RCC1 4	156..207
		RCC1 5	208..259
		RCC1 6	261..311
		RCC1	313..377	CDD:366085
		RCC1 7	313..366
		HECTc	702..1048	CDD:238033	111/358 (31%)
Nedd4	NP_648993.1	C2_NEDD4_NEDD4L	71..204	CDD:175999
		WW	248..277	CDD:278809
		WW	531..560	CDD:278809
		WW	581..613	CDD:197736	4/21 (19%)
		HECTc	650..1003	CDD:238033	111/372 (30%)
		HECTc	674..1003	CDD:214523	105/333 (32%)

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG5021
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	2	1.810