DRSC/TRiP Functional Genomics Resources

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Protein Alignment HERC3 and Nedd4

DIOPT Version :10

Sequence 1:NP_055421.1 Gene:HERC3 / 8916 HGNCID:4876 Length:1050 Species:Homo sapiens
Sequence 2:NP_648993.1 Gene:Nedd4 / 39958 FlyBaseID:FBgn0259174 Length:1007 Species:Drosophila melanogaster


Alignment Length:456 Identity:126/456 - (27%)
Similarity:210/456 - (46%) Gaps:55/456 - (12%)


- Green bases have known domain annotations that are detailed below.


Human   606 HVEYDTFYIPEISNLVDIQEDYLMWFLHQAGMKARPSIIQDTVTLCSYPFIFDAQAKTKMLQTDA 670
            |.:...|||...:.....::..|          :.|:|....|     |:..|.:.|.:..::..
  Fly   591 HTDGRVFYIDHNTRTTQWEDPRL----------SNPNIAGQAV-----PYSRDYKQKYEYFKSHI 640

Human   671 ELQMQVAVNGANLQNVFMLLTLEPLLARSPFLVLHVRRNNLVGDALRELSIHSDID-LKKPLKVI 734
            .       ...|:.|.|               .:.:||.:::.|:.|.:|..:..| ||..|.|.
  Fly   641 R-------KPTNVPNKF---------------EIRIRRTSILEDSYRIISSVTKTDLLKTKLWVE 683

Human   735 FDGEEAVDAGGVTKEFFLLLLKELLNPIYGMFTY-YQDSNLLWF---SDTCFVEH-NWFHLIGIT 794
            |:||..:|.||:.:|:|.||.||:.||.||:|.| ..|:..|..   |..|..|| ::|..||..
  Fly   684 FEGETGLDYGGLAREWFYLLSKEMFNPYYGLFEYSAMDNYTLQINNGSGLCNEEHLSYFKFIGRI 748

Human   795 CGLAIYNSTVVDLHFPLALYKKLLNVKPGLEDLKELSPTEGRSLQELLDYPGEDVEETFCLNFTI 859
            .|:|:|:..::|..|....||.:|.....|:|::.:......||..:.:.....:|.||||:   
  Fly   749 AGMAVYHGKLLDAFFIRPFYKMMLQKPIDLKDMESVDTEYYNSLMWIKENDPRILELTFCLD--- 810

Human   860 CRESYGVIEQKKLIPGGDNVTVCKDNRQEFVDAYVNYVFQISVHEWYTAFSSGFLKVCGGKVLEL 924
             .:.:|...|.:|.|||.|:.|..:|:.|::...:.:.|...|.|..::|..||..:....::::
  Fly   811 -EDVFGQKSQHELKPGGANIDVTNENKDEYIKLVIEWRFVARVKEQMSSFLDGFGSIIPLNLIKI 874

Human   925 FQPSELRAMMVGNSNYNWEELEETAIYKGDYSATHPTVKLFWETFHEFPLEKKKKFLLFLTGSDR 989
            |...||..:|.|..|.:.::..|..:|||||...|..::.||.....|..|.:.:.|.|:||:.|
  Fly   875 FDEHELELLMCGIQNIDVKDWRENTLYKGDYHMNHIIIQWFWRAVLSFSNEMRSRLLQFVTGTSR 939

Human   990 IPIYGMASL-------QIVIQSTASGEEYLPVAHTCYNLLDLPKYSSKEILSARLTQALDNYEGF 1047
            :|:.|...|       ...|:...:...: |.||||:|.||||.|.....|..:|.:|::..:||
  Fly   940 VPMNGFKELYGSNGPQMFTIEKWGTPNNF-PRAHTCFNRLDLPPYEGYLQLKDKLIKAIEGSQGF 1003

Human  1048 S 1048
            :
  Fly  1004 A 1004

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
HERC3NP_055421.1 RCC1 1 1..51
ATS1 3..341 CDD:444065
RCC1 2 52..101
RCC1 3 102..154
RCC1 4 156..207
RCC1 5 208..259
RCC1 6 261..311
RCC1 313..377 CDD:395335
RCC1 7 313..366
HECTc 702..1048 CDD:238033 111/358 (31%)
Nedd4NP_648993.1 C2_NEDD4_NEDD4L 71..204 CDD:175999
WW 248..277 CDD:459800
HUL4 <523..1003 CDD:227354 124/453 (27%)
Blue background indicates that the domain is not in the aligned region.

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