DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment HERC3 and Ube3a

DIOPT Version :9

Sequence 1:	NP_055421.1	Gene:	HERC3 / 8916	HGNCID:	4876	Length:	1050	Species:	Homo sapiens
Sequence 2:	NP_648452.1	Gene:	Ube3a / 39266	FlyBaseID:	FBgn0061469	Length:	973	Species:	Drosophila melanogaster

Alignment Length:	1089	Identity:	264/1089 - (24%)
Similarity:	431/1089 - (39%)	Gaps:	240/1089 - (22%)

- Green bases have known domain annotations that are detailed below.

Human    79 GALADQHIIHVACGESHSLALSDRGQLFSWGAGSDGQLGLMTTE-DSVAVPRLIQKLNQQTILQV 142
            |...|||:..|:.....:             ||:.|  |..|.| ...||..||::...|  ||.
  Fly     6 GGEDDQHLPGVSSASGSA-------------AGAVG--GRATPEMKRSAVRSLIKRYFHQ--LQS 53

Human   143 SCGNWHCLALAADGQFFTWGKNSHGQLGLGKEFPSQASPQRVRSLEGIPLAQVAAGGAHSFALSL 207
            .|||.:|              ::......||..|...:....|:|:
  Fly    54 GCGNANC--------------SNANCASSGKVAPMTPNEVAARALQ------------------- 85

Human   208 SGAVFGWGMNNAGQLGLSDEKDRESPCHVKLLRTQKVVYISCGEEHTAVLTKSGGVFTFGAGSCG 272
               :|    :...||..:...:..||..|.:|........|.|.. |:.:|.:....|
  Fly    86 ---LF----SQDAQLCEAFTSEANSPQDVDMLSPNDSSSSSSGSS-TSTITSASTTTT------- 135

Human   273 QLGHDSMNDEVNPRRVLELMGSE-VTQIACGRQHTLAFVPSSGLIYAFGCGARGQLGTGHTCNVK 336
                .|...:..|..|:..:.|. :||          .||...:     .||....|....|...
  Fly   136 ----TSRQSQSTPAAVVVPVSSPYLTQ----------SVPQLDI-----AGAEHSSGDSEPCTPT 181

Human   337 CPSPVKGYWAAHSGQLSARA--------------DRFKYHIVKQIFSGGD---QTFVLCSKYENY 384
            . :||      ||  |.|.:              ||. .|.:..:||..|   ::|:     .:.
  Fly   182 L-APV------HS--LDANSLIALYEQCRAADSYDRI-CHAIGVVFSSVDRLGKSFI-----RSA 231

Human   385 SPAV------------------DFRTMNQAHYTSLINDETIAVWRQKLSEHNNANTINGVVQILS 431
            .||.                  ..||:...|...  .|.|..|..|..|..|...|...|.....
  Fly   232 EPAASSSLQELLANSPGALNKEQLRTLEGEHDKD--EDSTQQVDEQSESAANATATAESVESEAE 294

Human   432 SAACWNGSFLEKKIDEHFKTSPKIPGIDLNSTRVLFEKLMNSQHSMILEQILNSFESCLIPQLSS 496
            .         |::.|:...:......:||...|.:...|...|...|.|::.:|     :.|||.
  Fly   295 P---------EEEDDDVCSSQSSDTLVDLPGLRRVQRLLFGCQIRAITEKLTSS-----VIQLSD 345

Human   497 ----SPPDVEAMRIYLILPEFPLLQDSKY------YITLTIP-LAMAILRLDTNPSKVLDNWWSQ 550
                ...|.|.: |:.::..|.|..::..      |:...:| |..|...:.......|...|:.
  Fly   346 WVIYMRTDWERV-IHCLVICFDLATNTNNSVVDMDYLDRVLPKLCQAASAMPVPAQARLARIWAA 409

Human   551 VCPKYFMKLVNLYKGAV-LYLLRGRKTF------------LIPVLFNNYITAAL----------- 591
            .|......|:...:..: |.:|...::.            |..|.:.|.:.:.|
  Fly   410 HCSDQLHSLIAACQQQITLQVLLDEESMRENESIISVTKVLKIVFYANILASELERPSCRVPLED 474

Human   592 -----------------------------KLLEKLYKVNLKVKHVE-------YDTFYIPEISNL 620
                                         |..|..::..|:|..::       .:.||...:|..
  Fly   475 RTEAATASGSAAVEDDLFVYNSLLEPHMPKFAEDQFEKELQVSAIDCRKPLIPLEEFYNEALSEN 539

Human   621 VDIQEDYLMWFLHQAGMKAR-PSIIQDTVTLCSYPFIFDAQAKTKMLQTDAELQMQVAVNGANLQ 684
            :.:..|||.:  ....|::. .|...:..:...|.||.....|...|..|:.::|.    .....
  Fly   540 IQMHHDYLSY--KTLAMESEIGSGHANYFSFMLYAFILTPSTKVDALYYDSRMRMY----SERYS 598

Human   685 NVFMLLTLEPLLARS----PFLVLHVRRNNLVGDA---LRELSIHSDIDLKKPLKVIFDGEEAVD 742
            ::..:|.....:.:.    |.|.|.|||:.|:.||   |..:::.:..||||.|.|.|.||:.:|
  Fly   599 SLHSILNNIGQVGQEDNPRPDLKLTVRRDQLINDALIGLEMVAMSNPKDLKKQLVVEFVGEQGID 663

Human   743 AGGVTKEFFLLLLKELLNPIYGMFTYYQDSNLLWFSDTCFVEHNWFHLIGITCGLAIYNSTVVDL 807
            .|||:||||.|:::|:.||.:|||...:::|.:||:.|.|.....|.||||..||||||:..:.:
  Fly   664 EGGVSKEFFQLIVEEIFNPAFGMFIQQEETNNMWFNATPFENGAQFTLIGIIIGLAIYNNVTLAV 728

Human   808 HFPLALYKKLLNVKPGLEDLKELSPTEGRSLQELLDYPGEDVEETFCLNFTIC-RESYGVIEQKK 871
            :||:.:|:||:.......||.:.||...:||:.:|||.|:|:||.|...|.|. .:.:|.:.|.:
  Fly   729 NFPMVVYRKLIGYCGTFADLSDWSPALYKSLKSMLDYQGQDMEEVFEQTFKISYSDVFGDVVQHE 793

Human   872 LIPGGDNVTVCKDNRQEFVDAYVNYVFQISVHEWYTAFSSGFLKVCGGKVLE-LFQPSELRAMMV 935
            |:|.|.:|.|.:.|::.||:.|.:::...::.:.:.||..||..|.....|: ||:|.|:..::.
  Fly   794 LVPNGQDVLVGQHNKELFVNLYSDFLLNTNIEQQFNAFRKGFEMVTDESPLKLLFRPEEIEMLVC 858

Human   936 GNSNYNWEELEETAIYKGDYSATHPTVKLFWETFHEFPLEKKKKFLLFLTGSDRIPIYGMASLQI 1000
            |:..:::.|||.:.:|:|.|:.....::.||...|..|.|.|.|.|.|.|||.|:|:.|:..|::
  Fly   859 GSREFDFVELENSTVYEGGYTEKSQYIQDFWSIVHAMPSEDKHKLLEFTTGSARVPVGGLKCLRL 923

Human  1001 VIQSTASGEEYLPVAHTCYNLLDLPKYSSKEILSARLTQALDNYEGFSL 1049
            :|.......:.||.:|||:|:|.||:|||:|.|..||.:|::..:||.:
  Fly   924 LITRHGPDSDRLPTSHTCFNVLLLPEYSSREKLEERLMKAINYSKGFGM 972

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
HERC3	NP_055421.1	RCC1 1	1..51
		ATS1	2..331	CDD:227511	50/253 (20%)
		RCC1 2	52..101		5/21 (24%)
		RCC1 3	102..154		17/52 (33%)
		RCC1 4	156..207		5/50 (10%)
		RCC1 5	208..259		10/50 (20%)
		RCC1 6	261..311		7/50 (14%)
		RCC1	313..377	CDD:366085	17/80 (21%)
		RCC1 7	313..366		13/66 (20%)
		HECTc	702..1048	CDD:238033	133/350 (38%)
Ube3a	NP_648452.1	AZUL	40..94	CDD:293166	17/95 (18%)
		HECTc	620..971	CDD:238033	133/350 (38%)
		HECTc	647..970	CDD:214523	123/322 (38%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG5021
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D276447at33208
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	3	2.820