Protein Alignment HERC3 and Ube3a

DIOPT Version :10

• Sequence 1: NP_055421.1
• Gene: HERC3 / 8916
• HGNCID: 4876
• Length: 1050
• Species: Homo sapiens
• Sequence 2: NP_648452.1
• Gene: Ube3a / 39266
• FlyBaseID: FBgn0061469
• Length: 973
• Species: Drosophila melanogaster
• Alignment Length: 1090
• Identity: 265/1090 - (24%)
• Similarity: 431/1090 - (39%)
• Gaps: 242/1090 - (22%)

Human    79 GALADQHIIHVACGESHSLALSDRGQLFSWGAGSDGQLGLMTTE-DSVAVPRLIQKLNQQTILQV 142
            |...|||:..|:.....:             ||:.|  |..|.| ...||..||::...|  ||.
  Fly     6 GGEDDQHLPGVSSASGSA-------------AGAVG--GRATPEMKRSAVRSLIKRYFHQ--LQS 53

Human   143 SCGNWHCLALAADGQFFTWGKNSHGQLGLGKEFPSQASPQRVRSLEGIPLAQVAAGGAHSFALSL 207
            .|||.:|              ::......||..|...:....|:|:
  Fly    54 GCGNANC--------------SNANCASSGKVAPMTPNEVAARALQ------------------- 85

Human   208 SGAVFGWGMNNAGQLGLSDEKDRESPCHVKLLRTQKVVYISCGEEHTAVLTKSGGVFTFGAGSCG 272
               :|    :...||..:...:..||..|.:|........|.|.. |:.:|.:....|
  Fly    86 ---LF----SQDAQLCEAFTSEANSPQDVDMLSPNDSSSSSSGSS-TSTITSASTTTT------- 135

Human   273 QLGHDSMNDEVNPRRVLELMGSE-VTQIACGRQHTLAFVPSSGLIYAFGCGARGQLGTGHTCNVK 336
                .|...:..|..|:..:.|. :||          .||...:     .||....|....|...
  Fly   136 ----TSRQSQSTPAAVVVPVSSPYLTQ----------SVPQLDI-----AGAEHSSGDSEPCTPT 181

Human   337 CPSPVKGYWAAHSGQLSAR-----------ADRFK--YHIVKQIFSGGD---QTFVLCSKYENYS 385
            . :||      ||  |.|.           ||.:.  .|.:..:||..|   ::|:     .:..
  Fly   182 L-APV------HS--LDANSLIALYEQCRAADSYDRICHAIGVVFSSVDRLGKSFI-----RSAE 232

Human   386 PAV------------------DFRTMNQAHYTSLINDETIAVWRQKLSEHNNANTINGVVQILSS 432
            ||.                  ..||:...|...  .|.|..|..|..|..|...|...|......
  Fly   233 PAASSSLQELLANSPGALNKEQLRTLEGEHDKD--EDSTQQVDEQSESAANATATAESVESEAEP 295

Human   433 AACWNGSFLEKKIDEHFKTSPKIPGIDLNSTRVLFEKLMNSQHSMILEQILNSFESCLIPQLSSS 497
                     |::.|:...:......:||...|.:...|...|...|.|::.:|     :.|||..
  Fly   296 ---------EEEDDDVCSSQSSDTLVDLPGLRRVQRLLFGCQIRAITEKLTSS-----VIQLSDW 346

Human   498 PPDVEAMR------IYLILPEFPLLQDSKY------YITLTIP-LAMAILRLDTNPSKVLDNWWS 549
               |..||      |:.::..|.|..::..      |:...:| |..|...:.......|...|:
  Fly   347 ---VIYMRTDWERVIHCLVICFDLATNTNNSVVDMDYLDRVLPKLCQAASAMPVPAQARLARIWA 408

Human   550 QVCPKYFMKLVNLYKGAV-LYLLRGRKTF------------LIPVLFNNYITAAL---------- 591
            ..|......|:...:..: |.:|...::.            |..|.:.|.:.:.|
  Fly   409 AHCSDQLHSLIAACQQQITLQVLLDEESMRENESIISVTKVLKIVFYANILASELERPSCRVPLE 473

Human   592 ------------------------------KLLEKLYKVNLKVKHVE-------YDTFYIPEISN 619
                                          |..|..::..|:|..::       .:.||...:|.
  Fly   474 DRTEAATASGSAAVEDDLFVYNSLLEPHMPKFAEDQFEKELQVSAIDCRKPLIPLEEFYNEALSE 538

Human   620 LVDIQEDYLMWFLHQAGMKAR-PSIIQDTVTLCSYPFIFDAQAKTKMLQTDAELQMQVAVNGANL 683
            .:.:..|||.:  ....|::. .|...:..:...|.||.....|...|..|:.::|.    ....
  Fly   539 NIQMHHDYLSY--KTLAMESEIGSGHANYFSFMLYAFILTPSTKVDALYYDSRMRMY----SERY 597

Human   684 QNVFMLLTLEPLLARS----PFLVLHVRRNNLVGDA---LRELSIHSDIDLKKPLKVIFDGEEAV 741
            .::..:|.....:.:.    |.|.|.|||:.|:.||   |..:::.:..||||.|.|.|.||:.:
  Fly   598 SSLHSILNNIGQVGQEDNPRPDLKLTVRRDQLINDALIGLEMVAMSNPKDLKKQLVVEFVGEQGI 662

Human   742 DAGGVTKEFFLLLLKELLNPIYGMFTYYQDSNLLWFSDTCFVEHNWFHLIGITCGLAIYNSTVVD 806
            |.|||:||||.|:::|:.||.:|||...:::|.:||:.|.|.....|.||||..||||||:..:.
  Fly   663 DEGGVSKEFFQLIVEEIFNPAFGMFIQQEETNNMWFNATPFENGAQFTLIGIIIGLAIYNNVTLA 727

Human   807 LHFPLALYKKLLNVKPGLEDLKELSPTEGRSLQELLDYPGEDVEETFCLNFTIC-RESYGVIEQK 870
            ::||:.:|:||:.......||.:.||...:||:.:|||.|:|:||.|...|.|. .:.:|.:.|.
  Fly   728 VNFPMVVYRKLIGYCGTFADLSDWSPALYKSLKSMLDYQGQDMEEVFEQTFKISYSDVFGDVVQH 792

Human   871 KLIPGGDNVTVCKDNRQEFVDAYVNYVFQISVHEWYTAFSSGFLKVCGGKVLE-LFQPSELRAMM 934
            :|:|.|.:|.|.:.|::.||:.|.:::...::.:.:.||..||..|.....|: ||:|.|:..::
  Fly   793 ELVPNGQDVLVGQHNKELFVNLYSDFLLNTNIEQQFNAFRKGFEMVTDESPLKLLFRPEEIEMLV 857

Human   935 VGNSNYNWEELEETAIYKGDYSATHPTVKLFWETFHEFPLEKKKKFLLFLTGSDRIPIYGMASLQ 999
            .|:..:::.|||.:.:|:|.|:.....::.||...|..|.|.|.|.|.|.|||.|:|:.|:..|:
  Fly   858 CGSREFDFVELENSTVYEGGYTEKSQYIQDFWSIVHAMPSEDKHKLLEFTTGSARVPVGGLKCLR 922

Human  1000 IVIQSTASGEEYLPVAHTCYNLLDLPKYSSKEILSARLTQALDNYEGFSL 1049
            ::|.......:.||.:|||:|:|.||:|||:|.|..||.:|::..:||.:
  Fly   923 LLITRHGPDSDRLPTSHTCFNVLLLPEYSSREKLEERLMKAINYSKGFGM 972

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
HERC3	NP_055421.1	RCC1 1	1..51
		ATS1	3..341	CDD:444065	51/263 (19%)
		RCC1 2	52..101		5/21 (24%)
		RCC1 3	102..154		17/52 (33%)
		RCC1 4	156..207		5/50 (10%)
		RCC1 5	208..259		10/50 (20%)
		RCC1 6	261..311		7/50 (14%)
		RCC1	313..377	CDD:395335	17/79 (22%)
		RCC1 7	313..366		13/65 (20%)
		HECTc	702..1048	CDD:238033	133/350 (38%)
Ube3a	NP_648452.1	AZUL	40..94	CDD:465173	17/95 (18%)
		HECTc	620..971	CDD:238033	133/350 (38%)