DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment HERC3 and CG5087

DIOPT Version :9

Sequence 1:	NP_055421.1	Gene:	HERC3 / 8916	HGNCID:	4876	Length:	1050	Species:	Homo sapiens
Sequence 2:	NP_648279.1	Gene:	CG5087 / 39035	FlyBaseID:	FBgn0035953	Length:	1078	Species:	Drosophila melanogaster

Alignment Length:	983	Identity:	227/983 - (23%)
Similarity:	378/983 - (38%)	Gaps:	226/983 - (22%)

- Green bases have known domain annotations that are detailed below.

Human   149 CLALAADGQFFTWGKNSHGQLGLGKEFPSQ--ASPQRVRSL-EGIP--LAQVAAGGAHSFALSLS 208
            ||....||.|   .:|      |..:|.|:  :.|..:..| :.:|  |.|.::.|....|||:|
  Fly   241 CLRPLIDGNF---SRN------LLAKFLSEILSVPALIYHLQQSVPQCLEQFSSMGLLKKALSIS 296

Human   209 GAV-----FGWGMNNAGQLGLSDEKDRESPCHVKLLRTQKVVYISCGEEHTAVLTKSGGVFTF-G 267
            |.|     ||..|.                                |.:..|.|.....:|.. |
  Fly   297 GDVQWFEEFGTSMP--------------------------------GTKSLAFLGNIVNLFNIDG 329

Human   268 AGSCGQLGHDSMNDEVNPRRVLELMGSEVTQIACGRQ-HTLAFVPSSGLIYAFGCGARGQLGTGH 331
            .|...:|.:..:.:...  .:|||:.:.||......| |.|                   || .|
  Fly   330 QGESKELAYPLLTETTT--SLLELIPNTVTTKGVFTQWHEL-------------------LG-WH 372

Human   332 TCNVKCPSPVKGYWAAHSGQLSARADRF----KYHIVKQIFSGGDQTFVLCSKYENYSPAVDFRT 392
            |     |.|.    .|.:..::....:|    .:..:|.:.  ||....:...||.    ::|::
  Fly   373 T-----PGPE----PAQNQNVALIKKQFHMLWDHRCIKLLL--GDLLKQINLNYER----IEFQS 422

Human   393 MNQAHYTSLINDETIAVWRQKLSEHNNANTIN--GVVQILSSAACWNGSFLEKKIDEHFKTSPKI 455
            ..|...::|:         ::..|.::...:|  ||.....|...|      :|:|     |.::
  Fly   423 PQQPSISNLL---------RRALERSSTRGVNLMGVASSKQSKQQW------RKLD-----SAEV 467

Human   456 PGIDLNSTRVLFEKLMNSQHSM---ILEQILNS----FESCLIPQLSSSPPDVEAMRIYLIL--- 510
              :.::....::...:|:...|   ||..|..|    ::..|:  ::|..|:. .|:.||.|
  Fly   468 --VQVSRICGMYYAALNTLSQMKLDILTGICYSDNVLYDIWLL--ITSLGPNC-GMKEYLELLKS 527

Human   511 ------PEFPLL----QDSKYYITLTIPLAMAILRLDTNPSKVLDNWWSQVCPKYFMKLVNLYKG 565
                  |:..:|    ....:|:|:   |....:..:.||.|:.|    .|...||:..: |||.
  Fly   528 ETNLQKPQTAMLMLFCDCMTHYVTI---LDEHEMYTEQNPFKLND----YVLLTYFLNNI-LYKL 584

Human   566 AVLYLLRGRKTFLIPVLFNNYITAALKLLEKLYKVNLKVKHVEYDTFYIPEISNLVDIQEDYLMW 630
            ....||.|.|..:...:|.:..|    |:..||:.:.:........:.|||:.....|.:
  Fly   585 INDNLLAGAKNIVQHPVFLSLHT----LMLCLYRRDCRRPFTPPKHWLIPEVKPSTFIND----- 640

Human   631 FLHQAGMKARPSIIQDTVTLCSYPFIFDAQAKTKMLQTDAELQMQVAVNGANLQNVFMLLTLEPL 695
             |.:|...|       .:.|...|.|...:.:.|:.:  ..:|.:.||.|         || |..
  Fly   641 -LEKAKRNA-------MLLLAKMPHIIPHEDRVKLFR--KFVQNEKAVMG---------LT-ESA 685

Human   696 LA--RSPFLVLHVRRNNLVGDALRELSIHSDIDLKKPLKVIFDG-----EEAVDAGGVTKEFFLL 753
            .|  ||..:|:|  |:.:|.|..|:|:......||..::|.|..     |..:|..||.|||...
  Fly   686 CASPRSALIVIH--RDRIVEDGYRQLAAQPTQALKGVIRVRFINQQGLHEAGIDQDGVFKEFLEE 748

Human   754 LLKELLNPIYGMFTYYQDSNLLWFSDTCFVEHN---WFHLIGITCGLAIYNSTVVDLHFPLALYK 815
            .:|::.:|...:|....|.. |:.|...:|:.|   .|..:|...|.|:|...|||:.|......
  Fly   749 TIKKVFDPSLNLFKTTSDQR-LYPSPISYVQDNHLELFEFVGRMLGKAVYEGIVVDVPFASFFLS 812

Human   816 KLLN-----VKPGLEDLKELSPTEGRSLQELLDYPGEDVEETFCLNFTICRESYGVIEQKKLIPG 875
            :||.     :...:::|..|.....|||..:..|. :||.: ..|.|::.::..|.|....|.||
  Fly   813 QLLGQTQQALYSCMDELPSLDNELYRSLTFIKHYK-QDVSD-LNLTFSVDQDVMGKIVTLALHPG 875

Human   876 GDNVTVCKDNRQEFVDAYVNYVFQISVHEWYTAFSSGFLKVCGGKVLELFQPSELRAMMVGN-SN 939
            |....|...|:..::.....:.....:.|...||:.||..:...:.|.||.|.||:.::.|: |.
  Fly   876 GKARVVNDHNKLVYIHYMAFFHMNTQIREQTIAFNRGFRSIVNPEWLSLFSPPELQRLISGDTSP 940

Human   940 YNWEELEETAIYKGDYSATHPTVKLFWETF-HEFPLEKKKKFLLFLTGSDRIPIYGMASLQ---- 999
            .:.::|::...|.|.:..||..|...|:.. .:|..|::|.||.|:|...:.|:.|.|.|:
  Fly   941 LDLKDLQKHTHYYGGFHDTHQVVCWLWDILAKDFTEEERKLFLKFVTSCSKPPLLGFAHLEPPFS 1005

Human  1000 ----IVIQSTASGE------------------EYLPVAHTCYNLLDLPKYSSKEILSARLTQALD 1042
                .|.....:|:                  ..||.:.||:|||.||.|..|..|..:|..|:.
  Fly  1006 IRCVEVSDDEDTGDTIGSVIRGFFAIRKKDPLNRLPTSSTCFNLLKLPNYQKKSTLRDKLRYAVS 1070

Human  1043 NYEGFSLA 1050
            :..||.|:
  Fly  1071 SNTGFELS 1078

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
HERC3	NP_055421.1	RCC1 1	1..51
		ATS1	2..331	CDD:227511	41/193 (21%)
		RCC1 2	52..101
		RCC1 3	102..154		2/4 (50%)
		RCC1 4	156..207		14/55 (25%)
		RCC1 5	208..259		9/55 (16%)
		RCC1 6	261..311		12/51 (24%)
		RCC1	313..377	CDD:366085	11/67 (16%)
		RCC1 7	313..366		8/56 (14%)
		HECTc	702..1048	CDD:238033	103/386 (27%)
CG5087	NP_648279.1	HECTc	694..1076	CDD:238033	103/386 (27%)
CG5087	NP_648279.1	HECTc	718..1075	CDD:214523	94/359 (26%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG5021
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	2	1.810