DRSC/TRiP Functional Genomics Resources

powered by:
logo

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits


Protein Alignment HERC3 and Ufd4

DIOPT Version :9

Sequence 1:NP_055421.1 Gene:HERC3 / 8916 HGNCID:4876 Length:1050 Species:Homo sapiens
Sequence 2:NP_609369.1 Gene:Ufd4 / 34378 FlyBaseID:FBgn0032208 Length:2727 Species:Drosophila melanogaster


Alignment Length:1124 Identity:213/1124 - (18%)
Similarity:356/1124 - (31%) Gaps:362/1124 - (32%)


- Green bases have known domain annotations that are detailed below.


Human   117 GLMTTEDSVAVPRLIQKLNQQTILQVSCGNWHCLALAADGQFFT--WGKNSHGQLGLGKEFPSQA 179
            ||:.|..::|..|..|..|.|                 |.|...  ...|.||.......|...:
  Fly  1774 GLLETFAAIARRRTSQGTNIQ-----------------DNQIMNAEANVNEHGDQNASGSFLGHS 1821

Human   180 SPQRVRSLEGIPLAQVAAGGAHSFALSLSGAVFGWGMNNAGQLGLSDEKD----RESPCHVKLLR 240
                |.||..:.|    :...||..||.:.:......||:..:..|:..:    ::|...:....
  Fly  1822 ----VTSLVKLAL----SSNFHSGLLSTAQSYPSLSSNNSENIAPSNPSNTSAGQQSASTINHTL 1878

Human   241 TQKVVYISCGEEHTAVLTKSGGVFTFGAGSCGQLGH-------DSMNDEVNPRRVLELMGSEVTQ 298
            |..:...|...|..::..     |.....:...||.       |..|||.......|.:|:.:.|
  Fly  1879 TMSLTSTSSDSEQVSLED-----FLESCRAPALLGDLDDEDDMDEDNDEEENEDEYEEVGNTLLQ 1938

Human   299 IACGRQHTLAFVPSSGLIYAFGCGARGQLGTGHTCNVKCPSPVKGYWAAHSGQLSARADRFKYHI 363
            :...| :.|.|:...                                 |...:|.....|..:  
  Fly  1939 VMVSR-NLLTFMDDE---------------------------------AMENRLVGVTKRKSW-- 1967

Human   364 VKQIFSGGDQTFVLCSKYENYSPAVDFR----TMNQAHYTSLINDETIAVWRQKLSEHNNANTIN 424
                    |..|||..::....||.|.|    .:||   ||.:....:.....|..:.....||.
  Fly  1968 --------DDEFVLKRQFSALIPAFDPRPGRTNVNQ---TSDLEISPLGAELPKPQQSGGPETIE 2021

Human   425 GVVQILSSAACWNGSFLEKKIDEHFKTSPKIPGIDLNSTRVL--------------FEKLMNSQH 475
            ..:..|.......|...|.:||        :...|....|.:              |.|:....:
  Fly  2022 QPLLGLKLRGPGIGGIPEVEID--------LSNTDWTIFRAVQELLQCSQLNKLDKFRKIWEPTY 2078

Human   476 SMILEQILNSFE--SCLIPQLSSSPPDVEAMRIYLILPEFPLLQDSKYYITLTIPLAMAILRLDT 538
            :::..::....:  :||..:.....|||.:             :.....::...|:.:.....|.
  Fly  2079 TIVYREVSPEAQESTCLESEEFPQTPDVSS-------------KSGASTLSPNSPMHIGFNVADN 2130

Human   539 NPSKVLDNWWSQVCPKYFMKLVNLYKGAVLYLLRGRKTFLIPVLFNNYITAALKLLEKLYKVNLK 603
            |...|.|                                            .|:||.::..:|..
  Fly  2131 NLCSVDD--------------------------------------------VLELLTQINGLNQS 2151

Human   604 ----------VKHVEYDTFYIPEISNLVDIQ-EDYLMWFLHQAGMKARPSIIQDTVTLCSYPFIF 657
                      |..:..|.|...:|:|.:..| :|.|:     ....|.|:..::....|  ||:|
  Fly  2152 EIDSDVKEHGVSVLSEDLFISKKITNKLQQQIQDPLV-----LASNALPNWCENLNQSC--PFLF 2209

Human   658 DAQAKTKMLQTDAELQMQVAVNGANLQNVFMLLTLEPLLARSPFLVLHVRRN------------- 709
            ..:.:        :|.......||:...|.:....:..:.|....::..||:             
  Fly  2210 PFETR--------QLYFNCTSFGASRSIVCLQSQRDVTVERQRIPIMSPRRDDHEFRIGRLKHER 2266

Human   710 -------NLVGDALRELSIHSDIDLKKPLKVIFDGEEAVDAGGVTKEFFLLLLKEL--------- 758
                   :|:..|::.:..|  .:.|..|:|.|..||.... |.|.||:.|:..|:         
  Fly  2267 VKVPRNEDLLMWAMQVMKTH--CNRKSVLEVEFLDEEGTGL-GPTLEFYALVAAEIQRSDLCMWL 2328

Human   759 -------------------LNPI--------YGMFTYYQDSNLLWFSDTC--FVEHNWFHLIGIT 794
                               ..|:        :|:|......|    |:.|  .:::.||  .|:.
  Fly  2329 CDDDLGEDTENSTQSAEGNSKPVGYYVNRREHGIFPAPLPQN----SEICENVLKYFWF--FGVF 2387

Human   795 CGLAIYNSTVVDLHFPLA----------------LYKKLLNVKPG-------------------- 823
            ....:.:..:||:  ||:                |.|.:.:.:.|                    
  Fly  2388 VAKVLQDMRLVDI--PLSTSFLQLLCHNKVLSRNLQKVISDRRNGDLSVVSEDSDIVETCTKLLR 2450

Human   824 --------------LEDLKELSPTEGRSLQEL---------LDYP-------------------- 845
                          ||:|||:.||..:.|||:         :::.                    
  Fly  2451 TDSNKSNAFGGILSLENLKEIDPTRYQFLQEMQNLLLRKQSIEFDDTISAEKKHELINELKLQTQ 2515

Human   846 -GEDVE-ETFCLNFTICRES--YGVIEQKKLIPGGDNVTVCKDNRQEFVDAYVNYVFQISVHEWY 906
             |.:|. |...|.||....|  || ..|.:|:|.|.:|.|..||.:.:.:..:|::.|..:.:..
  Fly  2516 NGLEVSLEDLALTFTYLPSSSIYG-YTQAELLPNGSSVNVTIDNLEAYCELLMNFILQDGIAQQM 2579

Human   907 TAFSSGFLKVCGGKVLELFQPSELRAMMVGNSNYNWEELEETAIY---KGDYSATHPTVKLFWET 968
            .|||.||.:|...|.|..|.|||.|.|:.|....:|.. |:...|   |..|:...|..:.|...
  Fly  2580 KAFSDGFNEVFPLKKLAAFTPSEARMMICGEQFPHWSR-EDIISYTEPKLGYNKDSPGFQRFVNV 2643

Human   969 FHEFPLEKKKKFLLFLTGSDRIPIYGMASLQ---IVIQSTASGEEYLPVAHTCYNLLDLPKYSSK 1030
            ......:::|.||.|.||...:|..|:|:|.   .|::...:|....|..:||.:.|.||.|.::
  Fly  2644 LLSMSGDERKAFLQFTTGCSSLPPGGLANLHPRLTVVRKVDAGVGSYPSVNTCVHYLKLPDYPTE 2708

Human  1031 EILSARLTQALDNYEGFSL 1049
            ||:..||..|... :||.|
  Fly  2709 EIMKERLLTATKE-KGFHL 2726

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
HERC3NP_055421.1 RCC1 1 1..51
ATS1 2..331 CDD:227511 42/226 (19%)
RCC1 2 52..101
RCC1 3 102..154 8/36 (22%)
RCC1 4 156..207 12/52 (23%)
RCC1 5 208..259 7/54 (13%)
RCC1 6 261..311 13/56 (23%)
RCC1 313..377 CDD:366085 5/63 (8%)
RCC1 7 313..366 3/52 (6%)
HECTc 702..1048 CDD:238033 109/492 (22%)
Ufd4NP_609369.1 ANK repeat 393..420 CDD:293786
ANK 396..509 CDD:238125
ANK repeat 422..453 CDD:293786
ANK repeat 455..484 CDD:293786
F5_F8_type_C 1173..1298 CDD:329041
MIB_HERC2 1333..1389 CDD:310955
DamX 1576..>1725 CDD:330571
HECTc 2265..2725 CDD:238033 107/473 (23%)
Blue background indicates that the domain is not in the aligned region.


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 00.000 Not matched by this tool.
Domainoid 00.000 Not matched by this tool.
eggNOG 1 0.900 - - E1_COG5021
Hieranoid 00.000 Not matched by this tool.
Homologene 00.000 Not matched by this tool.
Inparanoid 00.000 Not matched by this tool.
Isobase 00.000 Not matched by this tool.
OMA 00.000 Not matched by this tool.
OrthoDB 00.000 Not matched by this tool.
OrthoFinder 00.000 Not matched by this tool.
OrthoInspector 00.000 Not matched by this tool.
orthoMCL 00.000 Not matched by this tool.
Panther 00.000 Not matched by this tool.
Phylome 00.000 Not matched by this tool.
RoundUp 00.000 Not matched by this tool.
SonicParanoid 00.000 Not matched by this tool.
SwiftOrtho 00.000 Not matched by this tool.
TreeFam 00.000 Not matched by this tool.
User_Submission 00.000 Not matched by this tool.
10.900

Return to query results.
Submit another query.