DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment CACNA1G and cacna1g

DIOPT Version :9

Sequence 1:	NP_061496.2	Gene:	CACNA1G / 8913	HGNCID:	1394	Length:	2377	Species:	Homo sapiens
Sequence 2:	XP_021336019.1	Gene:	cacna1g / 563904	ZFINID:	ZDB-GENE-090514-2	Length:	2503	Species:	Danio rerio

Alignment Length:	2582	Identity:	1604/2582 - (62%)
Similarity:	1830/2582 - (70%)	Gaps:	307/2582 - (11%)

- Green bases have known domain annotations that are detailed below.

Human     5 EDGAGAEESGQ----------PRSFMRLNDLSGAGGR------------PGPGSAEKDPGSADSE 47
            |||....|..|          ||:|:.||||||.|.|            ...|.|.::..::|.|
Zfish     4 EDGGIISEDNQLNEAEGSSSLPRTFIPLNDLSGGGVRSELESDGGERRESAAGGAAEETSASDGE 68

Human    48 AEGLPYPALAPVVFFYLSQDSRPRSWCLRTVCNPWFERISMLVILLNCVTLGMFRPCEDIACDSQ 112
            |  ||||:|||||||||.|.:|||||||:.||||||||.|||||||||||||||.||||..|||:
Zfish    69 A--LPYPSLAPVVFFYLKQTTRPRSWCLKMVCNPWFERASMLVILLNCVTLGMFHPCEDSHCDSE 131

Human   113 RCRILQAFDDFIFAFFAVEMVVKMVALGIFGKKCYLGDTWNRLDFFIVIAGMLEYSLDLQNVSFS 177
            ||:||:.||||||||||||||:||||||||||||||||||||||||||:||||||||:|||||||
Zfish   132 RCKILEDFDDFIFAFFAVEMVIKMVALGIFGKKCYLGDTWNRLDFFIVLAGMLEYSLNLQNVSFS 196

Human   178 AVRTVRVLRPLRAINRVPSMRILVTLLLDTLPMLGNVLLLCFFVFFIFGIVGVQLWAGLLRNRCF 242
            |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
Zfish   197 AVRTVRVLRPLRAINRVPSMRILVTLLLDTLPMLGNVLLLCFFVFFIFGIVGVQLWAGLLRNRCF 261

Human   243 LPENFSLPLSVDLERYYQTENEDESPFICSQPRENGMRSCRSVPTLRGDGGGGPPCGLDYEAYNS 307
            ||||||||.|::|.:||.|||:||:|||||||||||||.|.|||||..:   |..|.||..:|||
Zfish   262 LPENFSLPTSLELRKYYHTENDDENPFICSQPRENGMRLCTSVPTLHEE---GRQCQLDMASYNS 323

Human   308 SSNTTCVNWNQYYTNCSAGEHNPFKGAINFDNIGYAWIAIFQVITLEGWVDIMYFVMDAHSFYNF 372
            :.||||||||:|||||||||.||||||||||||||||||||||||||||||||||||||||||||
Zfish   324 TDNTTCVNWNKYYTNCSAGEANPFKGAINFDNIGYAWIAIFQVITLEGWVDIMYFVMDAHSFYNF 388

Human   373 IYFILLIIVGSFFMINLCLVVIATQFSETKQRESQLMREQRVRFLSNASTLASFSEPGSCYEELL 437
            |||||||||||||||||||||||||||||||||||||:||||||.||||||.|:|||||||:|||
Zfish   389 IYFILLIIVGSFFMINLCLVVIATQFSETKQRESQLMKEQRVRFRSNASTLNSYSEPGSCYDELL 453

Human   438 KYLVYILRKAARRLAQVSRAAGVRVGL--LSSPAPLGGQETQPSSSCSRSHRRLSVHHLVHHHHH 500
            ||||:::||..|::|.:.||||.|.||  .:|| ||   |..|:....:..|:.|:.|::|||||
Zfish   454 KYLVHVIRKGTRQIAHLIRAAGRRAGLRICASP-PL---EAPPTKRRRQKQRQGSIRHIMHHHHH 514

Human   501 H-HHHYHLGNGTLRA--------PRASPEIQDRDANGSRRLMLP--PPSTPALSGA-PPGGAESV 553
            | |||||||||::|:        |..|..:   :.:|:..||||  .|...|.||: ....||||
Zfish   515 HLHHHYHLGNGSVRSDGGREVDNPSQSGIV---NKSGNVNLMLPVIVPQQDAFSGSFGHSSAESV 576

Human   554 HSFYHADCHLEPVRCQAPPPRSPSEASGR-----TVGSGKVYPTVHTSPPPETLKEKALVEVAAS 613
            ||.|....||||:||...|..:...|..|     .....|.|||:.:|...|.|:::.|...:
Zfish   577 HSVYQVSGHLEPLRCGPSPSPTVLHAYKRNSVPFAAPVHKNYPTLQSSLALEQLRQRILDPAS-- 639

Human   614 SGPPTLTSLNIPPGPYSSMHKLLETQSTGA----------CQSSCKISSPCLKADSGACGPDSCP 668
                .||||||||.|.::...|:|||....          | ||..|.: .|..|     |::||
Zfish   640 ----VLTSLNIPPNPINTSQCLVETQGPPGKVISKDALMNC-SSTNIDT-ALTYD-----PETCP 693

Human   669 YCARAGAGEVELAD-REMPDSDSEAVYEFTQDAQHSDLRDPHSRRQRSLGPDAEPSSVLAFWRLI 732
            |||::.|.:.|..| .|..|||||.||| ||.|.:.|.|.|..:::.:||  |..:.|:.||||:
Zfish   694 YCAKSMANDSEGIDGNETADSDSEGVYE-TQVAHYRDSRGPKKKKKFALG--ARATKVIDFWRLV 755

Human   733 CDTFRKIVDSKYFGRGIMIAILVNTLSMGIEYHEQPEELTNALEISNIVFTSLFALEMLLKLLVY 797
            |.||||||||||||:|||||||:|||||||||||||:|||||||||||||||||.||||||||||
Zfish   756 CGTFRKIVDSKYFGQGIMIAILINTLSMGIEYHEQPDELTNALEISNIVFTSLFVLEMLLKLLVY 820

Human   798 GPFGYIKNPYNIFDGVIVVISVWEIVGQQGGGLSVLRTFRLMRVLKLVRFLPALQRQLVVLMKTM 862
            |||||||||||||||:||||||||||||||||||||||||||||||||||:||||||||||||||
Zfish   821 GPFGYIKNPYNIFDGIIVVISVWEIVGQQGGGLSVLRTFRLMRVLKLVRFMPALQRQLVVLMKTM 885

Human   863 DNVATFCMLLMLFIFIFSILGMHLFGCKFASERDGDTLPDRKNFDSLLWAIVTVFQILTQEDWNK 927
            |||||||||||||||||||||||||||||.|||||||||||||||||||||||||||||||||||
Zfish   886 DNVATFCMLLMLFIFIFSILGMHLFGCKFGSERDGDTLPDRKNFDSLLWAIVTVFQILTQEDWNK 950

Human   928 VLYNGMASTSSWAALYFIALMTFGNYVLFNLLVAILVEGFQAEEISKREDASGQLSCIQLPVDS- 991
            ||||||||||..|||||||||||||||||||||||||||||.|||:||:|..|||||||||:||
Zfish   951 VLYNGMASTSPVAALYFIALMTFGNYVLFNLLVAILVEGFQTEEITKRDDLHGQLSCIQLPIDSG 1015

Human   992 -----------------------QGGDANKSESEPDFFSPSLDGDGDRKKCL---ALVSLGEHPE 1030
                                   ..|||:||:||.|.::.||:.....||.:   ::|.:..|.:
Zfish  1016 KGHVGVRIVKPNPDTMSTVLSSDLAGDASKSDSEADIYARSLEDVSGHKKDMSASSVVPINGHVD 1080

Human  1031 LRKSLLPPLIIHTAATPMSLPKSTSTGLGEALGPASRRTSSSGSAEPGAAHEMKSPPSARSSPHS 1095
            |:.||.||||.|||||||.:|| .|.|...||...||| .||.|.||..  :.|||.||||||::
Zfish  1081 LKSSLTPPLITHTAATPMPIPK-ISGGGDSALSQESRR-GSSVSMEPNG--QDKSPSSARSSPNA 1141

Human  1096 PWSAASSWTSRRSSRNSLGRAPSLKR-RSPSGERRSLLSGEGQESQDEEES-------SEEERAS 1152
            |.|:||||.|||||.||||||||||| :..||||||||||:||.|.||.::       ||.:.||
Zfish  1142 PLSSASSWNSRRSSWNSLGRAPSLKRQKHQSGERRSLLSGDGQSSSDEGDAGESMGGMSEGDDAS 1206

Human  1153 PAGSDH-----RHRGSLEREAKSSFDL-PDTLQVPGLHRTASGRGSASEHQDCNGKSASGRLARA 1211
            .|.:|.     |||.....|.:||||| |||||||..||:.|...:...:...|||::.......
Zfish  1207 LARTDSLGQRPRHRRMESLETRSSFDLHPDTLQVPYPHRSGSIHSARPPNFLSNGKTSPSAATTQ 1271

Human  1212 LRPDDPPLDGDDADDEGNLSKGERVRAWIRARLPACCLERDSWSAYIFPPQSRFRLLCHRIITHK 1276
            |..|:...:.|:||:|||||:..|:..|:..:.|..|.:|.:||.|:|||:||||:.|::|||||
Zfish  1272 LSLDEHHSEDDNADEEGNLSRRARLYRWLEHKQPEWCRQRVTWSLYLFPPESRFRVTCNKIITHK 1336

Human  1277 MFDHVVLVIIFLNCITIAMERPKIDPHSAERIFLTLSNYIFTAVFLAEMTVKVVALGWCFGEQAY 1341
            ||||||||||||||||||||||:|||.||||||||||||||||:|:.|||:||||||:||||:.|
Zfish  1337 MFDHVVLVIIFLNCITIAMERPRIDPSSAERIFLTLSNYIFTAIFVTEMTIKVVALGFCFGEKTY 1401

Human  1342 LRSSWNVLDGLLVLISVIDILVSMVSDSGTKILGMLRVLRLLRTLRPLRVISRAQGLKLVVETLM 1406
            |:||||:|||:||:|||||||||::|:|||||||||||||||||||||||||||.||||||||||
Zfish  1402 LKSSWNILDGMLVMISVIDILVSLISNSGTKILGMLRVLRLLRTLRPLRVISRAPGLKLVVETLM 1466

Human  1407 SSLKPIGNIVVICCAFFIIFGILGVQLFKGKFFVCQGEDTRNITNKSDCAEASYRWVRHKYNFDN 1471
            |||||||||||||||||||||||||||||||||||.|:|||||||||||..|:|:||||||||||
Zfish  1467 SSLKPIGNIVVICCAFFIIFGILGVQLFKGKFFVCHGDDTRNITNKSDCLLANYKWVRHKYNFDN 1531

Human  1472 LGQALMSLFVLASKDGWVDIMYDGLDAVGVDQQPIMNHNPWMLLYFISFLLIVAFFVLNMFVGVV 1536
            ||||||||||||||||||||||||||||||||||:||:|||||||||||||||||||||||||||
Zfish  1532 LGQALMSLFVLASKDGWVDIMYDGLDAVGVDQQPVMNYNPWMLLYFISFLLIVAFFVLNMFVGVV 1596

Human  1537 VENFHKCRQHQEEEEARRREEKRLRRLEKKRRNLMLDDVIASGSSASAASEAQCKPYYSDYSRFR 1601
            ||||||||::||||||:|||.||.:|.:|||||:||..|  |.||.....|||.||:||||...|
Zfish  1597 VENFHKCRRNQEEEEAKRREAKRQKRRDKKRRNIMLTGV--SWSSPDHTQEAQSKPFYSDYCPTR 1659

Human  1602 LLVHHLCTSHYLDLFITGVIGLNVVTMAMEHYQQPQILDEALKICNYIFTVIFVLESVFKLVAFG 1666
            .|::::|.|.|||||||.||.|||:||:||||.||::|.::||||||||||||||||:|||||||
Zfish  1660 RLIYNMCKSQYLDLFITIVIALNVITMSMEHYHQPKVLSDSLKICNYIFTVIFVLESIFKLVAFG 1724

Human  1667 FRRFFQDRWNQLDLAIVLLSIMGITLEEIEVNASLPINPTIIRIMRVLRIARVLKLLKMAVGMRA 1731
            |||||:||||||||||||||||||||||||||||||||||||||||||||.||||||||||||||
Zfish  1725 FRRFFKDRWNQLDLAIVLLSIMGITLEEIEVNASLPINPTIIRIMRVLRITRVLKLLKMAVGMRA 1789

Human  1732 LLDTVMQALPQVGNLGLLFMLLFFIFAALGVELFGDLECDETHPCEGLGRHATFRNFGMAFLTLF 1796
            |||||||||||||||||||||||||||||||||||||.|||.||||||||:|||:|||||||.||
Zfish  1790 LLDTVMQALPQVGNLGLLFMLLFFIFAALGVELFGDLICDELHPCEGLGRYATFKNFGMAFLLLF 1854

Human  1797 RVSTGDNWNGIMKDTLRDCDQES-TCYNTVISPIYFVSFVLTAQFVLVNVVIAVLMKHLEESNKE 1860
            |||||||||||||||||||.|:: .|||||:||||||||||||||||||||||||||||||||||
Zfish  1855 RVSTGDNWNGIMKDTLRDCSQDTGICYNTVVSPIYFVSFVLTAQFVLVNVVIAVLMKHLEESNKE 1919

Human  1861 AKE-EAELEAELELEMKTLS-----PQPHSP-LGSPFL-WPG-----------VEGP----DSPD 1902
            ||| |||.|.|||.||:.|.     .:.|.| |||..| .||           :.||    |||.
Zfish  1920 AKEAEAEAELELEQEMEALGRDREMQRGHMPRLGSGDLGGPGGSPWISRDHRDLSGPLYPIDSPT 1984

Human  1903 S---------------PKPGALHPAAHARSASHFSLEHPTDRQ-LFDTISLLIQGSLEWELKLMD 1951
            :               |.|               :||.|.:|: :||::||:||||||.||.|||
Zfish  1985 ADIRRDFEDHLRTDPDPPP---------------NLEPPLERRPMFDSVSLVIQGSLEGELSLMD 2034

Human  1952 ELAGPGGQPSAFPSAPSLGGSDPQIPLAEMEALSLTSEIVSEPSCSLALTDDSLPDDMHTLLLSA 2016
            .|:|......|.|..|:...::.||||||||||||    .||.|.||||||||:|||.:.|||::
Zfish  2035 NLSGSICHYYALPPLPNKHCTEKQIPLAEMEALSL----ASEKSWSLALTDDSVPDDFNPLLLTS 2095

Human  2017 LESNMQPHPTELP---------GPDLLTVRKSGVSRTHSLPNDSYM-------CRHGSTAEGPLG 2065
            .|.| ...|::.|         ...||:|:|:.|.|||||||||||       ..|.:....|
Zfish  2096 QECN-TTDPSDPPDTRQADEPTDEHLLSVKKTSVGRTHSLPNDSYMFLPLQSNSNHSTHTTSP-- 2157

Human  2066 HRGWGLPKAQSGSVLSVHSQPADTSYILQLPKDAPHLLQPHSAPTWGTIPKLPPPGRSPLAQRPL 2130
            |      .||:||..||.||..:.|..|.:|.|....:.|||.....:||::|||.|:....|.|
Zfish  2158 H------LAQTGSTASVQSQTEEASQHLTVPSDLFRPISPHSLSDSESIPRIPPPRRAHTLSRTL 2216

Human  2131 RRQAAIRTDS---LDVQGLGSREDLLA--EVSGPSPPLARAYSFWGQSSTQAQQH---------- 2180
            |||.|:..||   |..:| |..|..|.  |:|.|.||             |.|||
Zfish  2217 RRQVAVSADSQETLYTEG-GEAEGPLGLRELSDPLPP-------------QQQQHQPSLFLVPAT 2267

Human  2181 ---SRSHSKISKHM----------------TPPAPCPGPEPNWGKGPPETRSSLELDT---ELSW 2223
               |...|:.|.|.                :||.|.|         ||:.:...::|:   |:|.
Zfish  2268 PGASPKPSRPSVHTQHNPYDQYNVFSRSSHSPPVPPP---------PPDYKKQEDVDSVDQEVSR 2323

Human  2224 I-------SGDLLPPGGQEEPPSPRDLKKCYSVEAQSCQR-----RPTSWLDEQRRHSIAVSCLD 2276
            |       ..|.:...|..:..:.|.|||.:||:.|. ||     ||.||||:.|||||.| |..
Zfish  2324 IIRAGLTGRSDDVNREGTGDQCAKRQLKKYHSVDTQG-QRALLLPRPLSWLDDPRRHSIEV-CSS 2386

Human  2277 SGSQPHLGTDPSNLGG-----QPLGGPGSRPKKKLSPPSITIDPPESQGPRTP------------ 2324
            ..|.|...:..|....     |....|..| |||:|||.|::||||.  |..|
Zfish  2387 VESSPQRSSISSGFVSRADSLQQQSSPRGR-KKKMSPPCISVDPPED--PELPGGFHPALGIVPP 2448

Human  2325 --PSPGICLRRRAPSSDSKDPLASGPPDSMAASPSPKKDVLSLSGLS 2369
              ||...|||||||||:|||....|..:::.....|...:|:|...|
Zfish  2449 PLPSRDTCLRRRAPSSESKDSFDLGGGEALPQEGVPNSKLLTLPSFS 2495

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CACNA1G	NP_061496.2	Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1..48		19/64 (30%)
		I	68..398		289/329 (88%)
		Ion_trans	130..406	CDD:278921	246/275 (89%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	521..551		9/32 (28%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	569..600		8/35 (23%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	699..720		6/20 (30%)
		II	729..967		226/237 (95%)
		Ion_trans	760..968	CDD:278921	200/207 (97%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	991..1012		11/44 (25%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1047..1230		97/196 (49%)
		III	1263..1540		247/276 (89%)
		Ion_trans	1293..1547	CDD:278921	227/253 (90%)
		IV	1596..1854		224/258 (87%)
		Ion_trans	1628..1851	CDD:278921	202/223 (91%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1878..1917		16/75 (21%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	2107..2129		7/21 (33%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	2171..2244		21/111 (19%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	2272..2377		40/117 (34%)
cacna1g	XP_021336019.1	Ion_trans	99..422	CDD:306908	288/325 (89%)
		Ion_trans	765..998	CDD:306908	221/232 (95%)
		Ion_trans	1335..1607	CDD:306908	245/271 (90%)
		Ion_trans	1668..1910	CDD:306908	216/241 (90%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C194341439
Domainoid	1	1.000	582	1.000	Domainoid score	I1877
eggNOG	1	0.900	-	-		E1_KOG2301
Hieranoid	1	1.000	-	-
Homologene	1	1.000	-	-		H22544
Inparanoid	1	1.050	2556	1.000	Inparanoid score	I242
NCBI	1	1.000	-	-
OMA	1	1.010	-	-		QHG59758
OrthoDB	1	1.010	-	-		D172471at2759
OrthoFinder	1	1.000	-	-		FOG0001656
OrthoInspector	1	1.000	-	-		oto49166
orthoMCL	1	0.900	-	-		OOG6_102692
Panther	1	1.100	-	-	LDO	PTHR10037
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X1056
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	1	0.960	-	-
ZFIN	1	1.500	-	-
	17	17.270