|
Human 5 EDGAGAEESGQ----------PRSFMRLNDLSGAGGR------------PGPGSAEKDPGSADSE 47
|||....|..| ||:|:.||||||.|.| ...|.|.::..::|.|
Zfish 4 EDGGIISEDNQLNEAEGSSSLPRTFIPLNDLSGGGVRSELESDGGERRESAAGGAAEETSASDGE 68
Human 48 AEGLPYPALAPVVFFYLSQDSRPRSWCLRTVCNPWFERISMLVILLNCVTLGMFRPCEDIACDSQ 112
| ||||:|||||||||.|.:|||||||:.||||||||.|||||||||||||||.||||..|||:
Zfish 69 A--LPYPSLAPVVFFYLKQTTRPRSWCLKMVCNPWFERASMLVILLNCVTLGMFHPCEDSHCDSE 131
Human 113 RCRILQAFDDFIFAFFAVEMVVKMVALGIFGKKCYLGDTWNRLDFFIVIAGMLEYSLDLQNVSFS 177
||:||:.||||||||||||||:||||||||||||||||||||||||||:||||||||:|||||||
Zfish 132 RCKILEDFDDFIFAFFAVEMVIKMVALGIFGKKCYLGDTWNRLDFFIVLAGMLEYSLNLQNVSFS 196
Human 178 AVRTVRVLRPLRAINRVPSMRILVTLLLDTLPMLGNVLLLCFFVFFIFGIVGVQLWAGLLRNRCF 242
|||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
Zfish 197 AVRTVRVLRPLRAINRVPSMRILVTLLLDTLPMLGNVLLLCFFVFFIFGIVGVQLWAGLLRNRCF 261
Human 243 LPENFSLPLSVDLERYYQTENEDESPFICSQPRENGMRSCRSVPTLRGDGGGGPPCGLDYEAYNS 307
||||||||.|::|.:||.|||:||:|||||||||||||.|.|||||..: |..|.||..:|||
Zfish 262 LPENFSLPTSLELRKYYHTENDDENPFICSQPRENGMRLCTSVPTLHEE---GRQCQLDMASYNS 323
Human 308 SSNTTCVNWNQYYTNCSAGEHNPFKGAINFDNIGYAWIAIFQVITLEGWVDIMYFVMDAHSFYNF 372
:.||||||||:|||||||||.||||||||||||||||||||||||||||||||||||||||||||
Zfish 324 TDNTTCVNWNKYYTNCSAGEANPFKGAINFDNIGYAWIAIFQVITLEGWVDIMYFVMDAHSFYNF 388
Human 373 IYFILLIIVGSFFMINLCLVVIATQFSETKQRESQLMREQRVRFLSNASTLASFSEPGSCYEELL 437
|||||||||||||||||||||||||||||||||||||:||||||.||||||.|:|||||||:|||
Zfish 389 IYFILLIIVGSFFMINLCLVVIATQFSETKQRESQLMKEQRVRFRSNASTLNSYSEPGSCYDELL 453
Human 438 KYLVYILRKAARRLAQVSRAAGVRVGL--LSSPAPLGGQETQPSSSCSRSHRRLSVHHLVHHHHH 500
||||:::||..|::|.:.||||.|.|| .:|| || |..|:....:..|:.|:.|::|||||
Zfish 454 KYLVHVIRKGTRQIAHLIRAAGRRAGLRICASP-PL---EAPPTKRRRQKQRQGSIRHIMHHHHH 514
Human 501 H-HHHYHLGNGTLRA--------PRASPEIQDRDANGSRRLMLP--PPSTPALSGA-PPGGAESV 553
| |||||||||::|: |..|..: :.:|:..|||| .|...|.||: .|..||||
Zfish 515 HLHHHYHLGNGSVRSDGGREVDNPSQSGIV---NKSGNVNLMLPVIVPQQDAFSGSFGPSSAESV 576
Human 554 HSFYHADCHLEPVRCQAPPPRSPSEASGR-----TVGSGKVYPTVHTSPPPETLKEKALVEVAAS 613
||.|....||||:||...|..:...|..| .....|.|||:.:|...|.|:::.|...:
Zfish 577 HSVYQVSGHLEPLRCGPSPSPTVLHAYKRNSVPFAAPVHKNYPTLQSSLALEQLRQRILDPAS-- 639
Human 614 SGPPTLTSLNIPPGPYSSMHKLLETQ-------STGACQ--SSCKISSPCLKADSGACGPDSCPY 669
.||||||||.|.::...|:||| |..|.. ||..|.: .|..| |::|||
Zfish 640 ----VLTSLNIPPNPINTSQCLVETQGPPGKVISKDALMNCSSTNIDT-ALTYD-----PETCPY 694
Human 670 CARAGAGEVELAD-REMPDSDSEAVYEFTQDAQHSDLRDPHSRRQRSLGPDAEPSSVLAFWRLIC 733
||::.|.:.|..| .|..|||||.||| ||.|.:.|.|.|..:::.:|| |..:.|:.||||:|
Zfish 695 CAKSMANDSEGIDGNETADSDSEGVYE-TQVAHYRDSRGPKKKKKFALG--ARATKVIDFWRLVC 756
Human 734 DTFRKIVDSKYFGRGIMIAILVNTLSMGIEYHEQPEELTNALEISNIVFTSLFALEMLLKLLVYG 798
.||||||||||||:|||||||:|||||||||||||:|||||||||||||||||.|||||||||||
Zfish 757 GTFRKIVDSKYFGQGIMIAILINTLSMGIEYHEQPDELTNALEISNIVFTSLFVLEMLLKLLVYG 821
Human 799 PFGYIKNPYNIFDGVIVVISVWEIVGQQGGGLSVLRTFRLMRVLKLVRFLPALQRQLVVLMKTMD 863
||||||||||||||:||||||||||||||||||||||||||||||||||:|||||||||||||||
Zfish 822 PFGYIKNPYNIFDGIIVVISVWEIVGQQGGGLSVLRTFRLMRVLKLVRFMPALQRQLVVLMKTMD 886
Human 864 NVATFCMLLMLFIFIFSILGMHLFGCKFASERDGDTLPDRKNFDSLLWAIVTVFQILTQEDWNKV 928
||||||||||||||||||||||||||||.||||||||||||||||||||||||||||||||||||
Zfish 887 NVATFCMLLMLFIFIFSILGMHLFGCKFGSERDGDTLPDRKNFDSLLWAIVTVFQILTQEDWNKV 951
Human 929 LYNGMASTSSWAALYFIALMTFGNYVLFNLLVAILVEGFQAEEISKREDASGQLSCIQLPVDS-- 991
|||||||||..|||||||||||||||||||||||||||||.|||:||:|..|||||||||:||
Zfish 952 LYNGMASTSPVAALYFIALMTFGNYVLFNLLVAILVEGFQTEEITKRDDLHGQLSCIQLPIDSGK 1016
Human 992 ----------------------QGGDANKSESEPDFFSPSLDGDGDRKKCL---ALVSLGEHPEL 1031
..|||:||:||.|.::.||:.....||.: ::|.:..|.:|
Zfish 1017 GHVGVRIVKPNPDTLSTVLSSDLAGDASKSDSEADIYARSLEDVSGHKKDMSASSVVPINGHVDL 1081
Human 1032 RKSLLPPLIIHTAATPMSLPKSTSTGLGEALGPASRRTSSSGSAEPGAAHEMKSPPSARSSPHSP 1096
:.||.||||.|||||||.:|| .|.|...||...||| .||.|.||.. :.|||.||||||::|
Zfish 1082 KSSLTPPLITHTAATPMPIPK-ISGGGDSALSQESRR-GSSVSMEPNG--QDKSPSSARSSPNAP 1142
Human 1097 WSAASSWTSRRSSRNSLGRAPSLKR-RSPSGERRSLLSGEGQESQDEEES-------SEEERASP 1153
.|:||||.|||||.||||||||||| :..||||||||||:||.|.||.:: ||.:.||.
Zfish 1143 LSSASSWNSRRSSWNSLGRAPSLKRQKHQSGERRSLLSGDGQSSSDEGDAGESMGGMSEGDDASL 1207
Human 1154 AGSDH-----RHRGSLEREAKSSFDL-PDTLQVPGLHRTASGRGSASEHQDCNGKSASGRLARAL 1212
|.:|. |||.....|.:||||| |||||||..||:.|...:...:...|||::.......|
Zfish 1208 ARTDSLGQRPRHRRMESLETRSSFDLHPDTLQVPYPHRSGSIHSARPPNFLSNGKTSPSAATTQL 1272
Human 1213 RPDDPPLDGDDADDEGNLSKGERVRAWIRARLPACCLERDSWSAYIFPPQSRFRLLCHRIITHKM 1277
..|:...:.|:||:|||||:..|:..|:..:.|..|.:|.:||.|:|||:||||:.|::||||||
Zfish 1273 SLDEHHSEDDNADEEGNLSRRARLYRWLEHKQPEWCRQRVTWSLYLFPPESRFRVTCNKIITHKM 1337
Human 1278 FDHVVLVIIFLNCITIAMERPKIDPHSAERIFLTLSNYIFTAVFLAEMTVKVVALGWCFGEQAYL 1342
|||||||||||||||||||||:|||.||||||||||||||||:|:.|||:||||||:||||:.||
Zfish 1338 FDHVVLVIIFLNCITIAMERPRIDPSSAERIFLTLSNYIFTAIFVTEMTIKVVALGFCFGEKTYL 1402
Human 1343 RSSWNVLDGLLVLISVIDILVSMVSDSGTKILGMLRVLRLLRTLRPLRVISRAQGLKLVVETLMS 1407
:||||:|||:||:|||||||||::|:|||||||||||||||||||||||||||.|||||||||||
Zfish 1403 KSSWNILDGMLVMISVIDILVSLISNSGTKILGMLRVLRLLRTLRPLRVISRAPGLKLVVETLMS 1467
Human 1408 SLKPIGNIVVICCAFFIIFGILGVQLFKGKFFVCQGEDTRNITNKSDCAEASYRWVRHKYNFDNL 1472
||||||||||||||||||||||||||||||||||.|:|||||||||||..|:|:|||||||||||
Zfish 1468 SLKPIGNIVVICCAFFIIFGILGVQLFKGKFFVCHGDDTRNITNKSDCLLANYKWVRHKYNFDNL 1532
Human 1473 GQALMSLFVLASKDGWVDIMYDGLDAVGVDQQPIMNHNPWMLLYFISFLLIVAFFVLNMFVGVVV 1537
|||||||||||||||||||||||||||||||||:||:||||||||||||||||||||||||||||
Zfish 1533 GQALMSLFVLASKDGWVDIMYDGLDAVGVDQQPVMNYNPWMLLYFISFLLIVAFFVLNMFVGVVV 1597
Human 1538 ENFHKCRQHQEEEEARRREEKRLRRLEKKRRNLMLDDVIASGSSASAASEAQCKPYYSDYSRFRL 1602
|||||||::||||||:|||.||.:|.:|||||:||..| |.||.....|||.||:||||...|.
Zfish 1598 ENFHKCRRNQEEEEAKRREAKRQKRRDKKRRNIMLTGV--SWSSPDHTQEAQSKPFYSDYCPTRR 1660
Human 1603 LVHHLCTSHYLDLFITGVIGLNVVTMAMEHYQQPQILDEALKICNYIFTVIFVLESVFKLVAFGF 1667
|::::|.|.|||||||.||.|||:||:||||.||::|.::||||||||||||||||:||||||||
Zfish 1661 LIYNMCKSQYLDLFITIVIALNVITMSMEHYHQPKVLSDSLKICNYIFTVIFVLESIFKLVAFGF 1725
Human 1668 RRFFQDRWNQLDLAIVLLSIMGITLEEIEVNASLPINPTIIRIMRVLRIARVLKLLKMAVGMRAL 1732
||||:||||||||||||||||||||||||||||||||||||||||||||.|||||||||||||||
Zfish 1726 RRFFKDRWNQLDLAIVLLSIMGITLEEIEVNASLPINPTIIRIMRVLRITRVLKLLKMAVGMRAL 1790
Human 1733 LDTVMQALPQVGNLGLLFMLLFFIFAALGVELFGDLECDETHPCEGLGRHATFRNFGMAFLTLFR 1797
||||||||||||||||||||||||||||||||||||.|||.||||||||:|||:|||||||.|||
Zfish 1791 LDTVMQALPQVGNLGLLFMLLFFIFAALGVELFGDLICDELHPCEGLGRYATFKNFGMAFLLLFR 1855
Human 1798 VSTGDNWNGIMKDTLRDCDQES-TCYNTVISPIYFVSFVLTAQFVLVNVVIAVLMKHLEESNKEA 1861
||||||||||||||||||.|:: .|||||:|||||||||||||||||||||||||||||||||||
Zfish 1856 VSTGDNWNGIMKDTLRDCSQDTGICYNTVVSPIYFVSFVLTAQFVLVNVVIAVLMKHLEESNKEA 1920
Human 1862 KE-EAELEAELELEMKTLS-----PQPHSP-LGSPFL-WPG-----------VEGPDSP-DSPKP 1906
|| |||.|.|||.||:.|. .:.|.| |||..| .|| :.||..| |||.
Zfish 1921 KEAEAEAELELEQEMEALGRDREMQRGHMPRLGSGDLGGPGGSPWISRDHRDLSGPLYPIDSPT- 1984
Human 1907 GALHPAAHARSASHFSLEHPTDRQLFDTISLLIQGSLEWELKLMDELAGPGGQPSAFPSAPSLGG 1971
|.....|.....||......:...::||||.||.|||.|:|......|.|..|:...
Zfish 1985 --------ADIRRDFEDHLRTDPDPPPNLEPPLEGSLEGELSLMDNLSGSICHYYALPPLPNKHC 2041
Human 1972 SDPQIPLAEMEALSLTSEIVSEPSCSLALTDDSLPDDMHTLLLSALESNMQPHPTELP------- 2029
::.|||||||||||| .||.|.||||||||:|||.:.|||::.|.| ...|::.|
Zfish 2042 TEKQIPLAEMEALSL----ASEKSWSLALTDDSVPDDFNPLLLTSQECN-TTDPSDPPDTRQADE 2101
Human 2030 --GPDLLTVRKSGVSRTHSLPNDSYM-------CRHGSTAEGPLGHRGWGLPKAQSGSVLSVHSQ 2085
...||:|:|:.|.||||||||||| ..|.:....| | .||:||..||.||
Zfish 2102 PTDEHLLSVKKTSVGRTHSLPNDSYMFLPLQSNSNHSTHTTSP--H------LAQTGSTASVQSQ 2158
Human 2086 PADTSYILQLPKDAPHLLQPHSAPTWGTIPKLPPPGRSPLAQRPLRRQAAIRTDS---LDVQGLG 2147
..:.|..|.:|.|....:.|||.....:||::|||.|:....|.||||.|:..|| |..:| |
Zfish 2159 TEEASQHLTVPSDLFRPISPHSLSDSESIPRIPPPRRAHTLSRTLRRQVAVSADSQETLYTEG-G 2222
Human 2148 SREDLLA--EVSGPSPPLARAYSFWGQSSTQAQQH-------------SRSHSKISKHM------ 2191
..|..|. |:|.|.|| ...|.||| |...|:.|.|.
Zfish 2223 EAEGPLGLRELSDPLPP----------QQQQQQQHQPSLFLVPATPGASPKPSRPSVHTQHNPYD 2277
Human 2192 ----------TPPAPCPGPEPNWGKGPPETRSSLELDT---ELSWI-------SGDLLPPGGQEE 2236
:||.|.| ||:.:...::|: |:|.| ..|.:...|..:
Zfish 2278 QYNVFSRSSHSPPVPPP---------PPDYKKQEDVDSVDQEVSRIIRAGLTGRSDDVNREGTGD 2333
Human 2237 PPSPRDLKKCYSVEAQSCQR-----RPTSWLDEQRRHSIAVSCLDSGSQPHLGTDPSNLGG---- 2292
..:.|.|||.:||:.|. || ||.||||:.|||||.| |....|.|...:..|....
Zfish 2334 QCAKRQLKKYHSVDTQG-QRALLLPRPLSWLDDPRRHSIEV-CSSVESSPQRSSISSGFVSRADS 2396
Human 2293 -QPLGGPGSRPKKKLSPPSITIDPPESQGPRTP--------------PSPGICLRRRAPSSDSKD 2342
|....|..| |||:|||.|::||||. |..| ||...|||||||||:|||
Zfish 2397 LQQQSSPRGR-KKKMSPPCISVDPPED--PELPGGFHPALGIVPPPLPSRDTCLRRRAPSSESKD 2458
Human 2343 PLASGPPDSMAASPSPKKDVLSLSGLS 2369
....|..:::.....|...:|:|...|
Zfish 2459 SFDLGGGEALPQEGVPNSKLLTLPSFS 2485
| 
