DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment CACNA1G and cca-1

DIOPT Version :9

Sequence 1:	NP_061496.2	Gene:	CACNA1G / 8913	HGNCID:	1394	Length:	2377	Species:	Homo sapiens
Sequence 2:	NP_001367691.1	Gene:	cca-1 / 181045	WormBaseID:	WBGene00000367	Length:	1885	Species:	Caenorhabditis elegans

Alignment Length:	2086	Identity:	886/2086 - (42%)
Similarity:	1148/2086 - (55%)	Gaps:	422/2086 - (20%)

- Green bases have known domain annotations that are detailed below.

Human    15 QPRSFMRLNDLSGAGGRPG-------------PGSAEKDPG-------------SADSEAEGLPY 53
            |.:|..|..|:...|...|             ..|:|..|.             ..:.|:| |||
Worm    39 QSQSTRRHEDVEALGSIEGSKETLQLSEHGRLASSSEASPSRWEGRQIEWGNEEQIEEESE-LPY 102

Human    54 PALAPVVFFYLSQDSRPRSWCLRTVCNPWFERISMLVILLNCVTLGMFRPCED-IACDSQRCRIL 117
            |..|........|...||.|.|:.|.:|||:||:|.||::|||||||:||||| ..||:.||:||
Worm   103 PGFAEPALRCFYQARPPRKWALQMVMSPWFDRITMAVIMINCVTLGMYRPCEDGPDCDTYRCQIL 167

Human   118 QAFDDFIFAFFAVEMVVKMVALGIFGKKCYLGDTWNRLDFFIVIAGMLEYSLDLQ---NVSFSAV 179
            ...|:.||.:||.|||:|::|||.:|...|:.|||||||||||:||:.|:.|...   |::.:|:
Worm   168 DIIDNCIFVYFAFEMVIKIMALGFYGPAAYMSDTWNRLDFFIVMAGIAEFVLHEYLGGNINLTAI 232

Human   180 RTVRVLRPLRAINRVPSMRILVTLLLDTLPMLGNVLLLCFFVFFIFGIVGVQLWAGLLRNRCF-- 242
            |||||||||||:||:|||||||.|||||||||||||||||||||||||||||||||||||||.
Worm   233 RTVRVLRPLRAVNRIPSMRILVNLLLDTLPMLGNVLLLCFFVFFIFGIVGVQLWAGLLRNRCVIN 297

Human   243 LPENFS-----LPLSVDLERYYQTENEDESPFICSQPRENGMRSCRSVPTLRGDGGGGPPCGLDY 302
            ||:..|     |..:|.|.|:|..| :....:|||||..||:.:|.::|....|   |..|.|..
Worm   298 LPKTISENQSALFNNVKLTRFYIPE-DTSLEYICSQPDANGLHTCSNLPPYTVD---GVKCNLTL 358

Human   303 EAYNSSSNTTCVNWNQYYTNCSAGEHNPFKGAINFDNIGYAWIAIFQVITLEGWVDIMYFVMDAH 367
            :.|:..:|.:|:|||.||..|...:.|||:|:::|||||:||:|||.||:||||.||||:|.|||
Worm   359 DEYDKVTNDSCINWNIYYNECQVMQRNPFQGSVSFDNIGFAWVAIFLVISLEGWTDIMYYVQDAH 423

Human   368 SFYNFIYFILLIIVGSFFMINLCLVVIATQFSETKQRESQLMREQRVRFLSNASTLASFSEPG-- 430
            ||:|:|||:|||::|:|||||||||||||||:|||:||::.|.::|...|:..|...:.||.|
Worm   424 SFWNWIYFVLLIVIGAFFMINLCLVVIATQFAETKRRETERMLQERKMLLNRDSISCTGSEIGGA 488

Human   431 -------SCYEELLKYLVYILRKAARRLAQVSRAAGVRVGLLSSPAPLGGQETQPSSSCSRSHRR 488
                   :.|...::::.:..|: .:|.|:....|.:..
Worm   489 SSKEEGDTVYAAFVRFIGHTFRR-TKRAAKKKYTAYMEE-------------------------- 526

Human   489 LSVHHLVHHHHHHHHHYHLGNGTLRAPRASPEIQDRDANGSRRLMLPPPSTPALSGAPPGGAESV 553
                                    ||.|.|.|.|.|     |:..|...:|  ||
Worm   527 ------------------------RAERKSSERQQR-----RKSKLDDMAT--LS---------- 550

Human   554 HSFYHADCHLEPVRCQAPPPRSPSEASGRTVGSGKVYPTVHTSPPPETLKEKALVEVAASSGPPT 618
                                                           .::|||..|    ....|
Worm   551 -----------------------------------------------RIEEKAEDE----EDETT 564

Human   619 LTSLNIPPGPYSSMHKLLETQSTGACQSSCKI-SSPCLKADSG-ACGPDSCPYCARAGAGEVELA 681
            :|..|        ....:|....|......|| ..|.:|..:| :.||
Worm   565 ITREN--------GDDQIEQNGDGVRIKRVKIEEEPKIKIGNGNSNGP----------------- 604

Human   682 DREMPDSDSEAVYEFTQDAQHSDLRDPHSRRQRSLGPDAEPSSVLAFWRLICDTFRKIVDSKYFG 746
            ..:...||.|:    .:|.:...:.|....:::|     .||.:  :|  ..:..:|.|...:|.
Worm   605 HYKHSSSDEES----DEDGEEDQVYDGEEAKKKS-----TPSKL--WW--FREKIQKFVICDHFT 656

Human   747 RGIMIAILVNTLSMGIEYHEQPEELTNALEISNIVFTSLFALEMLLKLLVYGPFGYIKNPYNIFD 811
            |||::||||||||||:|||:|||.||..||.||:.||:|||||||||::..|.|||:.:.:|:||
Worm   657 RGILVAILVNTLSMGVEYHQQPEILTVILEYSNLFFTALFALEMLLKIIASGLFGYLADGFNLFD 721

Human   812 GVIVVISVWEIVGQQGGGLSVLRTFRLMRVLKLVRFLPALQRQLVVLMKTMDNVATFCMLLMLFI 876
            |.||.:||.|:..:..|||||||||||:|:||||||:|||:.||||:::|||||..|..||:|||
Worm   722 GGIVALSVLELFQEGKGGLSVLRTFRLLRILKLVRFMPALRYQLVVMLRTMDNVTVFFGLLVLFI 786

Human   877 FIFSILGMHLFGCKF--------------ASERDGDTL---------------------P----- 901
            ||||||||:||||||              ...::.|||                     |
Worm   787 FIFSILGMNLFGCKFCKVEEKFLGGLAKKCERKNFDTLLWALITVTLGMVLFGCKFCNHPDTGLQ 851

Human   902 -------------DRKNFDSLLWAIVTVFQILTQEDWNKVLYNGMASTSSWAALYFIALMTFGNY 953
                         ||.|||:.|:|.|||||||||||||.||:||||.|:.||||||:||||||||
Worm   852 CTSAQVISSICECDRMNFDNFLFATVTVFQILTQEDWNMVLFNGMAQTNPWAALYFVALMTFGNY 916

Human   954 VLFNLLVAILVEGFQAEEISKREDASGQLSCIQLPVDSQGGDANKSESEPDFFSPSLDGDGDRKK 1018
            |||||||||||||||.   ||.|:                    |.:.|.|....:::.:.:||:
Worm   917 VLFNLLVAILVEGFQE---SKEEE--------------------KRQLEEDARKQAVEEEDERKR 958

Human  1019 CLALVSLGEHPELRKSLLPPLIIHTAATPMSLPKSTSTGLGEALGPASRRTSSSGSAEPGAAHEM 1083
            .|.|:                          :.|:||......:.||     ......|.:..|.
Worm   959 ELELI--------------------------IAKTTSPAFNNGVAPA-----ECTCQRPSSPEES 992

Human  1084 KSPPSARSSPHSPWSAASSWTSRRSSRNSLGRAPSLKRRSPSG-----ERRSLLSGEGQESQDEE 1143
            .||....::.|                      ||.:|:..:.     ::|.:|          .
Worm   993 PSPRLLSANYH----------------------PSPERKHSANLDAIIDKRLVL----------R 1025

Human  1144 ESSEEERASPAGSDHRHRGSLEREAKSSFDLPDTLQVPGLHRTASGRGSASEHQDCN----GK-- 1202
            .|:..:| ||. |:.|....|.|.|  |..||....||...:..........|.:.|    |:
Worm  1026 NSAPFDR-SPV-SEGRDDSRLNRHA--SLVLPVANGVPYRRQRVHSWSGLCHHFNPNCPVHGRRA 1086

Human  1203 -----------SASGRLARALRPDDPPLDGDDADDEGNLSKGE-RVRAWIRARLPACCL-ERDSW 1254
                       .||..|.:||           |::|   .:.| :...::|..|...|| .|..:
Worm  1087 LIETYAREKFLEASQELKQAL-----------AEEE---KRNEAKQNTFVRKLLKKTCLHNRTEF 1137

Human  1255 SAYIFPPQSRFRLLCHRIITHKMFDHVVLVIIFLNCITIAMERPKIDPHSAERIFLTLSNYIFTA 1319
            |.::..|::..|:.|.:....|.||:.||..|.:||||:|||||.|.|.|.||.||.:|.||||.
Worm  1138 SLFLMGPKNPLRIKCLQTTQKKWFDYTVLFFIGINCITLAMERPSIPPDSFERQFLHISGYIFTV 1202

Human  1320 VFLAEMTVKVVALGWCFGEQAYLRSSWNVLDGLLVLISVIDILVSMVSDSGT-KILGMLRVLRLL 1383
            :|..||.:||:|.|...|:.||.:..||:|||:||:||:|:|...:::...: ||.|::||||||
Worm  1203 IFTGEMMMKVIANGCFIGQAAYFKDGWNILDGILVVISLINIAFELLATGDSPKIFGVIRVLRLL 1267

Human  1384 RTLRPLRVISRAQGLKLVVETLMSSLKPIGNIVVICCAFFIIFGILGVQLFKGKFFVCQGEDTRN 1448
            |.|||||||:||.|:||||.||:||||||||||:|||.|||||||||||||||..:.|.|.:..|
Worm  1268 RALRPLRVINRAPGVKLVVMTLISSLKPIGNIVLICCTFFIIFGILGVQLFKGMMYHCIGPEVGN 1332

Human  1449 ITNKSDCAEASYR--WVRHKYNFDNLGQALMSLFVLASKDGWVDIMYDGLDAVGVDQQPIMNHNP 1511
            :|.|:||.| .||  ||.|:||||||||||||||||:||||||.|||.|:||||||.|||.|:|.
Worm  1333 VTTKADCIE-DYRNKWVNHRYNFDNLGQALMSLFVLSSKDGWVSIMYQGIDAVGVDVQPIENYNE 1396

Human  1512 WMLLYFISFLLIVAFFVLNMFVGVVVENFHKCRQHQEEEEARRREEKRLRRLEKKRRNLMLDDVI 1576
            |.::|||||||:|.||||||||||||||||||::..|:|...:.:||||:|..|:::       .
Worm  1397 WRMIYFISFLLLVGFFVLNMFVGVVVENFHKCKEALEKEMREKEKEKRLKRKLKRQK-------F 1454

Human  1577 ASGSSASAASEAQCKPYYSDYSRFRLLVHHLCTSHYLDLFITGVIGLNVVTMAMEHYQQPQILDE 1641
            ....:.......:..|||.||...||.:|.:.||.|.||.|..|||:||::||||.|..|..|..
Worm  1455 EESMAGKRKKMERNYPYYHDYGHTRLFLHGIVTSKYFDLAIAAVIGINVISMAMEFYMMPMGLKY 1519

Human  1642 ALKICNYIFTVIFVLESVFKLVAFGFRRFFQDRWNQLDLAIVLLSIMGITLEEIEVNASLPINPT 1706
            .||..||.||.:|.||:..||:|.||:|||.::||:||:.||:|||.||..||.|. ..||||||
Worm  1520 VLKALNYFFTAVFTLEAAMKLIALGFKRFFIEKWNRLDMFIVILSIAGIIFEEFEA-LELPINPT 1583

Human  1707 IIRIMRVLRIARVLKLLKMAVGMRALLDTVMQALPQVGNLGLLFMLLFFIFAALGVELFGDLECD 1771
            |||:||||||||||||||||.|:|:|||||.:|||||||||.||.|||||||||||||||.|||.
Worm  1584 IIRVMRVLRIARVLKLLKMAKGIRSLLDTVGEALPQVGNLGSLFFLLFFIFAALGVELFGKLECS 1648

Human  1772 ETHPCEGLGRHATFRNFGMAFLTLFRVSTGDNWNGIMKDTLR-DCD-----QESTCYNTVISPIY 1830
            |.|||:|||.||.|:|||||||||||::|||||||||||.|| |||     :.:.|.:.:::|.:
Worm  1649 EDHPCDGLGEHAHFKNFGMAFLTLFRIATGDNWNGIMKDALRDDCDSSDHCETNCCVDPILAPCF 1713

Human  1831 FVSFVLTAQFVLVNVVIAVLMKHLEESNK-EAKEEAE-----LEAELELEMKTLSPQPHSPLGSP 1889
            ||.|||.:||||||||:|||||||||||| :|:..||     :|.|:.........:.|.||...
Worm  1714 FVIFVLISQFVLVNVVVAVLMKHLEESNKRDAEGPAEPTGENIENEITKSDDDEIVEEHEPLAIE 1778

Human  1890 FLWPGVEGPDSPDSPKPGALHPAAHARSASHFSLEHPTDRQLFDTISLLIQGSLEWELKLMDELA 1954
            .:..|....:......|....|..|. .....|:      |:.:...:.::..||...:...|..
Worm  1779 HVKEGELDEEEETEEGPTTQIPDGHG-GIKRLSM------QVLEQELIEVERHLEERYRRASECL 1836

Human  1955 GPGGQP 1960
            |...||
Worm  1837 GGELQP 1842

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CACNA1G	NP_061496.2	Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1..48		9/58 (16%)
		I	68..398		203/340 (60%)
		Ion_trans	130..406	CDD:278921	173/285 (61%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	521..551		7/29 (24%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	569..600		0/30 (0%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	699..720		3/20 (15%)
		II	729..967		160/290 (55%)
		Ion_trans	760..968	CDD:278921	146/260 (56%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	991..1012		3/20 (15%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1047..1230		39/204 (19%)
		III	1263..1540		176/279 (63%)
		Ion_trans	1293..1547	CDD:278921	169/256 (66%)
		IV	1596..1854		172/263 (65%)
		Ion_trans	1628..1851	CDD:278921	153/228 (67%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1878..1917		7/38 (18%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	2107..2129
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	2171..2244
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	2272..2377
cca-1	NP_001367691.1	Ion_trans	129..461	CDD:395416	203/335 (61%)
		Ion_trans	659..938	CDD:395416	160/301 (53%)
		Ion_trans	1159..1430	CDD:395416	179/271 (66%)
		Ion_trans	1488..1721	CDD:395416	153/233 (66%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	1	1.000	420	1.000	Domainoid score	I349
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	1507	1.000	Inparanoid score	I41
Isobase	0	0.000	Not matched by this tool.
OMA	1	1.010	-	-		QHG59758
OrthoDB	1	1.010	-	-		D172471at2759
OrthoFinder	1	1.000	-	-		FOG0001656
OrthoInspector	1	1.000	-	-		otm15167
orthoMCL	1	0.900	-	-		OOG6_102692
Panther	1	1.100	-	-	O	PTHR10037
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X1056
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	11	10.980