DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment CACNA1H and cacna1h

DIOPT Version :9

Sequence 1:	XP_006721026.1	Gene:	CACNA1H / 8912	HGNCID:	1395	Length:	2358	Species:	Homo sapiens
Sequence 2:	XP_031748783.1	Gene:	cacna1h / 100494894	XenbaseID:	XB-GENE-6042121	Length:	2460	Species:	Xenopus tropicalis

Alignment Length:	2486	Identity:	1594/2486 - (64%)
Similarity:	1848/2486 - (74%)	Gaps:	260/2486 - (10%)

- Green bases have known domain annotations that are detailed below.

Human     1 MTEGAR-------AADEVRVPLGAPPPGPAALVGASPESPGAPGREAERGS-------ELGVSPS 51
            ||:|.|       |.|::|||:   ||.|.|         |.|..|.:.|:       .||...|
Frog     1 MTDGERKEPFQPLAGDDIRVPI---PPTPQA---------GDPSEEEDAGNAEKSALGSLGSGGS 53

Human    52 ESPAAERGAELGADEEQRVPYPALAATVFFCLGQTTRPRSWCLRLVCNPWFEHVSMLVIMLNCVT 116
            .....|:|  :|::|.::|||||||.||||||.||||||:|||||||||||||||||||:|||||
Frog    54 SGRGREQG--MGSEEGEQVPYPALAPTVFFCLSQTTRPRNWCLRLVCNPWFEHVSMLVILLNCVT 116

Human   117 LGMFRPCEDVECGSERCNILEAFDAFIFAFFAVEMVIKMVALGLFGQKCYLGDTWNRLDFFIVVA 181
            ||||:||||..|.|||||||||||.||||||||||||||||||:||||||||||||.||||||:|
Frog   117 LGMFQPCEDTNCMSERCNILEAFDGFIFAFFAVEMVIKMVALGIFGQKCYLGDTWNWLDFFIVMA 181

Human   182 GMMEYSLDGHNVSLSAIRTVRVLRPLRAINRVPSMRILVTLLLDTLPMLGNVLLLCFFVFFIFGI 246
            ||:||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
Frog   182 GMLEYSLDGHNVSLSAIRTVRVLRPLRAINRVPSMRILVTLLLDTLPMLGNVLLLCFFVFFIFGI 246

Human   247 VGVQLWAGLLRNRCFLDSAFVRNNNLTFLRPYYQTEEGEENPFICSSRRDNGMQKCSHIPGRREL 311
            |||||||||||||||:|:.||.:.|.|.||||||.::.|:||:||||.|||||.||..||.
Frog   247 VGVQLWAGLLRNRCFMDTNFVMSYNFTPLRPYYQVDDAEDNPYICSSNRDNGMLKCQDIPP---- 307

Human   312 RMPCTLGWEAYTQ-PQAEGVGAARNACINWNQYYNVCRSGDSNPHNGAINFDNIGYAWIAIFQVI 375
            :|.|:..:  |:. |       :||:|:|.|||||||:.|:.|||.|||||||||||||||||||
Frog   308 KMDCSHVY--YSDFP-------SRNSCVNINQYYNVCKPGEFNPHKGAINFDNIGYAWIAIFQVI 363

Human   376 TLEGWVDIMYYVMDAHSFYNFIYFILLIIVGSFFMINLCLVVIATQFSETKQRESQLMREQRARH 440
            ||||||||||||||||||||||||||||||||||||||||||||||||||||||:|||:|||||:
Frog   364 TLEGWVDIMYYVMDAHSFYNFIYFILLIIVGSFFMINLCLVVIATQFSETKQRENQLMQEQRARY 428

Human   441 LSNDSTLASFSEPGSCYEELLKYVGHIFRKVKRRSLRLYARWQSRWRKKVDP-SAVQGQGPGHRQ 504
            ||||||:||||||||||||||||:.|||||||||:||||..||::.||||.| |....||   |.
Frog   429 LSNDSTIASFSEPGSCYEELLKYICHIFRKVKRRTLRLYNNWQNKRRKKVQPNSNTNSQG---RH 490

Human   505 RRAGRHTASVHHLVYHHHHHHHHHYHFSHGSPRRPGPEPGACDTRLV------RAGAPPSPPSPG 563
            |:..|...|:|||::|||||||||||.|:||||.|...|..||..:.      :...||:.||..
Frog   491 RKCKRRITSIHHLIHHHHHHHHHHYHISNGSPRGPRSSPEICDVEMKIMKPKNQLRLPPASPSLQ 555

Human   564 RGPPDAESVHSIYHADCHIEGPQERARVAHAAATAAASLRLATGL--GTMNYPTILPSGVGSGKG 626
            ...|::|:||||||||||:|.||   |.:..::.|:::::|..||  ..||||||:||..    .
Frog   556 SMSPNSEAVHSIYHADCHLEAPQ---RKSSKSSNASSNIKLNAGLNHSNMNYPTIMPSQA----N 613

Human   627 STSPG--PKGKWAGGPPGTGGHGPLSLNSPDPYEKIPHVVGEHGLGQAPGHLSGLSVPCPLPSPP 689
            .|||.  ||||..|....:....|:|:.: |.:.|..|:||||||.::...||||||||.||||.
Frog   614 KTSPATLPKGKRNGSNAVSLLSSPVSMKA-DSFGKTNHLVGEHGLCRSSSKLSGLSVPCSLPSPQ 677

Human   690 AGTLTCELKSCPYCTRALEDPEGELSGSESGDSDGRGVYEFTQDVRHGDRWDPTRPPRATDTPGP 754
            ...|.||:::||||...||:|:.|||.|||.:||..||||||||:|.||:.|..
Frog   678 PSPLLCEIQNCPYCANLLENPDLELSDSESCESDSNGVYEFTQDLRRGDQRDQV----------- 731

Human   755 GPGSPQRRAQQRAAPGEPGWMGRLWVTFSGKLRRIVDSKYFSRGIMMAILVNTLSMGVEYHEQPE 819
                 |:..:.:..|.|...:..||..|:.:|:||||||||:||||:|||:||||||:|||||||
Frog   732 -----QKGRKLKTKPKEANKVYLLWEEFTVRLKRIVDSKYFNRGIMIAILINTLSMGIEYHEQPE 791

Human   820 ELTNALEISNIVFTSMFALEMLLKLLACGPLGYIRNPYNIFDGIIVVISVWEIVGQADGGLSVLR 884
            |||||||||||||||||||||||||||.|...||:||||||||||||||||||:||:||||||||
Frog   792 ELTNALEISNIVFTSMFALEMLLKLLAFGIFQYIKNPYNIFDGIIVVISVWEIIGQSDGGLSVLR 856

Human   885 TFRLLRVLKLVRFLPALRRQLVVLVKTMDNVATFCTLLMLFIFIFSILGMHLFGCKFSLKTDTGD 949
            |||||||||||||:|||||||||||||||||||||.|||||||||||||||||||||:...|||:
Frog   857 TFRLLRVLKLVRFMPALRRQLVVLVKTMDNVATFCMLLMLFIFIFSILGMHLFGCKFTWTADTGE 921

Human   950 TVPDRKNFDSLLWAIVTVFQILTQEDWNVVLYNGMASTSSWAALYFVALMTFGNYVLFNLLVAIL 1014
            ||.|||||||||||||||||||||||||:||||||||||||||||||||||||||||||||||||
Frog   922 TVKDRKNFDSLLWAIVTVFQILTQEDWNMVLYNGMASTSSWAALYFVALMTFGNYVLFNLLVAIL 986

Human  1015 VEGFQAEGDANRSDTDEDKTSVHFEEDFHKLRELQTTELKMCSLAVTPNGHLEGRGSLSPPLIMC 1079
            ||||||||||.||||:|||.|.:|:||..||:||:..||||.||||||||||:.|.|:.||:||.
Frog   987 VEGFQAEGDATRSDTEEDKASGNFDEDLEKLKELRAAELKMYSLAVTPNGHLDPRSSMPPPIIMR 1051

Human  1080 TAATPMPTPKSSPFLDAAPSLPDSRRGSSSSGDPPLGDQKPPASLRSSPCAPWGPSGAWSSRRSS 1144
            |||||||||||||.:|::....||||.||.|.||.:.|||..|||||:||.|||....|.|||||
Frog  1052 TAATPMPTPKSSPCMDSSHPFGDSRRESSVSIDPSIVDQKSLASLRSTPCTPWGTYSNWGSRRSS 1116

Human  1145 WSSLGRAPSLKRRGQCGERESLLSGEGKGSTDDEAEDGRAAPGPRATPLRRAESLDPR------- 1202
            |:|||||||:|::.|.|||||||||||||||||:::|.:::|..|.:..|||.|||.|
Frog  1117 WNSLGRAPSIKKKSQSGERESLLSGEGKGSTDDDSDDCKSSPAARVSLHRRAGSLDTRGSLDIPD 1181

Human  1203 -----------PLRPAALPPTKCRDRDGQVVALPSDFFLRIDSHREDAAELDDDSEDSCCLRLHK 1256
                       .:.|.|:.|:..:|.:|:::.:|||.|:|::.||||..|.:||.|||.|.|:.|
Frog  1182 FLQVPTLRHSLSVSPLAMVPSDYQDCNGKMMHVPSDLFVRVEKHREDPLEYEDDIEDSYCFRIRK 1246

Human  1257 VLEPYKPQWCRSREAWALYLFSPQNRFRVSCQKVITHKMFDHVVLVFIFLNCVTIALERPDIDPG 1321
            :||||||.||::.|.|:||:|||||:||:.|||||.||||||||||||||||:|||||||||||.
Frog  1247 MLEPYKPTWCKTHEDWSLYMFSPQNQFRMMCQKVIAHKMFDHVVLVFIFLNCITIALERPDIDPN 1311

Human  1322 STERVFLSVSNYIFTAIFVAEMMVKVVALGLLSGEHAYLQSSWNLLDGLLVLVSLVDIVVAMASA 1386
            |.||:||||||||||||||.||.:||||||.:|||:.|||||||:|||:||.||::||||::|||
Frog  1312 SLERIFLSVSNYIFTAIFVLEMAIKVVALGFVSGENTYLQSSWNVLDGILVFVSIIDIVVSLASA 1376

Human  1387 GGAKILGVLRVLRLLRTLRPLRVISRAPGLKLVVETLISSLRPIGNIVLICCAFFIIFGILGVQL 1451
            |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
Frog  1377 GGAKILGVLRVLRLLRTLRPLRVISRAPGLKLVVETLISSLRPIGNIVLICCAFFIIFGILGVQL 1441

Human  1452 FKGKFYYCEGPDTRNISTKAQCRAAHYRWVRRKYNFDNLGQALMSLFVLSSKDGWVNIMYDGLDA 1516
            ||||||||||.:||||:.:::|..|.|:|||||||||||||||||||||||||||||||||||||
Frog  1442 FKGKFYYCEGLETRNITNRSECTRARYKWVRRKYNFDNLGQALMSLFVLSSKDGWVNIMYDGLDA 1506

Human  1517 VGVDQQPVQNHNPWMLLYFISFLLIVSFFVLNMFVGVVVENFHKCRQHQEAEEARRREEKRLRRL 1581
            |..|.|||:||||||||||||||||||||||||||||||||||||||||||||||||||||||||
Frog  1507 VATDVQPVKNHNPWMLLYFISFLLIVSFFVLNMFVGVVVENFHKCRQHQEAEEARRREEKRLRRL 1571

Human  1582 ERRRRSKALPVAVAVAEAQRRPYYADYSPTRRSIHSLCTSHYLDLFITFIICVNVITMSMEHYNQ 1646
            |::||||||    .::|||||||||:|||.|..||::|||||||||||.|||:||||||||||||
Frog  1572 EKKRRSKAL----YMSEAQRRPYYAEYSPARLYIHTMCTSHYLDLFITCIICINVITMSMEHYNQ 1632

Human  1647 PKSLDEALKYCNYVFTIVFVFEAALKLVAFGFRRFFKDRWNQLDLAIVLLSLMGITLEEIEMSAA 1711
            |||||||||||||||||||||||..||||||||||||||||||||||||||:|||||||||::|:
Frog  1633 PKSLDEALKYCNYVFTIVFVFEALFKLVAFGFRRFFKDRWNQLDLAIVLLSIMGITLEEIEINAS 1697

Human  1712 LPINPTIIRIMRVLRIARVLKLLKMATGMRALLDTVVQALPQVGNLGLLFMLLFFIYAALGVELF 1776
            |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
Frog  1698 LPINPTIIRIMRVLRIARVLKLLKMATGMRALLDTVVQALPQVGNLGLLFMLLFFIYAALGVELF 1762

Human  1777 GRLECSEDNPCEGLSRHATFSNFGMAFLTLFRVSTGDNWNGIMKDTLRECSREDKHCLSYLPALS 1841
            |:|.|:|:||||||||||||.|||||||||||||||||||||||||||||:.:||:||:|||.:|
Frog  1763 GKLVCNEENPCEGLSRHATFENFGMAFLTLFRVSTGDNWNGIMKDTLRECNSDDKNCLTYLPVIS 1827

Human  1842 PVYFVTFVLVAQFVLVNVVVAVLMKHLEESNKEAREDAELDAEIELEMAQG---------PGS-A 1896
            |||||||||:||||||||||||||||||||||||:||||:|||||:||::.         |.| .
Frog  1828 PVYFVTFVLIAQFVLVNVVVAVLMKHLEESNKEAKEDAEMDAEIEMEMSRALTPISGGCTPASDG 1892

Human  1897 RRVDADRPPL---------------------PQESPGA--------------------------- 1913
            :..:..:.||                     |:...||
Frog  1893 KGTEGGQDPLKGELLKQVGGAVCQENVTLVIPESMEGAALLNDAVPACSIYQQQALPLPLQPCVL 1957

Human  1914 ---------RD---APNLVA-RKVSVSRMLSLPNDSYMFRPVVPASAPHPRPLQEVEMETYGAGT 1965
                     ||   :.||:| :|:||||||||||||||||||:||.:.:  |||||  ||....:
Frog  1958 GHEDGDFQRRDGSGSRNLLAVKKISVSRMLSLPNDSYMFRPVLPAKSSY--PLQEV--ETTEDNS 2018

Human  1966 PLGSVASVHSPPAESCASLQIPL------AVSSPARSGEPLHALSPRGTARSPSLSRLLCRQEAV 2024
            |.||.||:||.|.::.:.|.||:      :||:...|.:......|..::|||||:|.|.||||:
Frog  2019 PHGSTASLHSQPGDNNSLLNIPVECQPQASVSNHQDSADLPKIPPPHTSSRSPSLNRSLRRQEAI 2083

Human  2025 HTDSLEGKIDS------PRDTLDPAEPGEKTPVRP-------VTQGGSLQSPPR---SPRPASVR 2073
            ..||::...||      ..::|....|...|.| |       |:..|:.||.||   .||.:||.
Frog  2084 RMDSVDQGGDSKDLNVESTESLHLGAPSVTTLV-PNLLCTLNVSLQGTPQSSPRLSPQPRHSSVL 2147

Human  2074 TRKHTFGQRCVSSRPAAPGG-----EEA--EASDPADEEVSHITSSACPWQPTAEPHGPEASPV- 2130
            |..|.:.|..:.|||::...     ||:  |:||.||||||||.|||..|:.::.......||.
Frog  2148 THNHVYSQHSIPSRPSSVSSGNSNPEESMFESSDLADEEVSHINSSAKDWRGSSNNRSHSVSPFI 2212

Human  2131 -------------------------AGGERDLRRLYSVDAQGFLDKPGRADEQWRPSAELG---- 2166
                                     :|.::||::.||||.||||.||...|:|.|.|.|:.
Frog  2213 SQSSSPPPLSPSLKNCNSTVSLAGSSGKDKDLKKFYSVDTQGFLAKPCWGDDQRRHSIEICPSID 2277

Human  2167 --------SGEPGEAKAWGPEAEPAL--GARRKKKMSPPCISVEPPAEDEG--SARPSAAEGGST 2219
                    |.|.....:....::|..  |.||||||||||||::||.||||  ::|..|:| .|.
Frog  2278 DGDSCFDLSMEDKHCSSVLIRSDPEYINGVRRKKKMSPPCISIDPPMEDEGGTASRTKASE-NSM 2341

Human  2220 TLRRRTPSCEATPHRDSLEPTEGSGAGGDPAAKGERWGQASCRAEHLTVPSFAFEPLDLGVPSGD 2284
            .|||||||||:|.:||||:.::..  .||..:|.:|..|..||.|||.:||::|:.:|     |:
Frog  2342 MLRRRTPSCESTAYRDSLDLSDNQ--LGDQISKTDRRTQVPCRNEHLIIPSYSFDKVD-----GN 2399

Human  2285 PFLD---GSHSVTPES 2297
            .|.|   .|...||.|
Frog  2400 GFSDLISNSGGSTPTS 2415

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CACNA1H	XP_006721026.1	Ion_trans	149..430	CDD:278921	227/281 (81%)
		Ion_trans	810..1019	CDD:278921	191/208 (92%)
		Ion_trans	1317..1565	CDD:278921	215/247 (87%)
		Ion_trans	1639..1852	CDD:278921	194/212 (92%)
cacna1h	XP_031748783.1	None

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	1	1.000	530	1.000	Domainoid score	I3253
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	1	1.000	-	-
Homologene	1	1.000	-	-		H56913
Inparanoid	1	1.050	2890	1.000	Inparanoid score	I268
NCBI	1	1.000	-	-
OMA	1	1.010	-	-		QHG59758
OrthoDB	1	1.010	-	-		D172471at2759
OrthoFinder	1	1.000	-	-		FOG0001656
OrthoInspector	1	1.000	-	-		oto155781
Panther	1	1.100	-	-	LDO	PTHR10037
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R8566
SonicParanoid	1	1.000	-	-		X1056
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	13	13.110