Protein Alignment CCNB1 and CycG

DIOPT Version :10

• Sequence 1: NP_114172.1
• Gene: CCNB1 / 891
• HGNCID: 1579
• Length: 433
• Species: Homo sapiens
• Sequence 2: NP_524609.2
• Gene: CycG / 43724
• FlyBaseID: FBgn0039858
• Length: 566
• Species: Drosophila melanogaster
• Alignment Length: 323
• Identity: 66/323 - (20%)
• Similarity: 123/323 - (38%)
• Gaps: 61/323 - (18%)

Human   132 TSGCAPAE----------EDLCQAFSDVILAVNDVDAEDGA-----DPNLCSEYVKDIYAYLRQL 181
            |.|.|..|          |||.::.:..:...::.:.|..:     :..|.:....::|..|::.
  Fly   183 TPGAAGLEYQKYEQQQQLEDLAESEAGAVGGASNNNGESSSSLKKLEDQLHALTSDELYETLKEY 247

Human   182 EEEQAVRPKYLL-----GREVTGNMRAILIDWLVQVQMKFRLLQETMYMTVSIIDRFMQNNCVPK 241
            :..|......||     .||||...|......|..::|.:.|..:.::..:|::|||:....|..
  Fly   248 DVLQDKFHTVLLLPKESRREVTAGGRDGSAYVLRCLKMWYELPSDVLFSAMSLVDRFLDRMAVKP 312

Human   242 KMLQLVGVTAMFIASKYEEMYPPEIGDFAFVTDNTYTKHQIRQMEMKILRALNFGLGR-PL-PLH 304
            |.:..:.|.:..:|.|..::.|....|...::....|...:.:|...|...|...:|. |: .:.
  Fly   313 KHMACMSVASFHLAIKQLDLKPIPAEDLVTISQCGCTAGDLERMAGVIANKLGVQMGHAPITSVS 377

Human   305 FLR--------RASKIGE---------VDVEQHTLAKYLMELTMLDYDMVHFPPSQIAAGAFCLA 352
            :||        .|.:||.         :.:|:   .:..:|:.|.|.......||.:|....||.
  Fly   378 YLRIYYALFRNLAKEIGGDFFKFYQQLIKLEE---LENRLEILMCDVKTTVITPSTLALVLICLH 439

Human   353 LKILDNGEWT---PTLQHYLSYTEESLLPVMQHL---------AKNVVMVNQGLTKHMTVKNK 403
            |.......:|   |.|:|...|    :|.:.|::         ..::|   .|:..|...:||
  Fly   440 LDFHIKESYTRGSPELKHVFEY----ILFLQQYMRIPDRVFTCGFSIV---SGILSHYNGQNK 495

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
CCNB1	NP_114172.1	Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	19..47
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	93..116
		CYCLIN_CCNB1_rpt1	167..295	CDD:410268	28/132 (21%)
		Interaction with CDK2	169..177		1/7 (14%)
		Interaction with CDK2	258..261		0/2 (0%)
		CYCLIN_CCNB1_rpt2	300..420	CDD:410272	28/134 (21%)
CycG	NP_524609.2	CYCLIN_CCNG	273..364	CDD:410227	18/90 (20%)