Protein Alignment CCNB1 and CycB3

DIOPT Version :10

• Sequence 1: NP_114172.1
• Gene: CCNB1 / 891
• HGNCID: 1579
• Length: 433
• Species: Homo sapiens
• Sequence 2: NP_651303.2
• Gene: CycB3 / 42971
• FlyBaseID: FBgn0015625
• Length: 575
• Species: Drosophila melanogaster
• Alignment Length: 551
• Identity: 147/551 - (26%)
• Similarity: 228/551 - (41%)
• Gaps: 163/551 - (29%)

Human     6 TRNSKINAEN---KAKINMAGAKRVPTAPAATSKPGLRPRTALGDIGNKV--------------- 52
            |.|...|.||   :||      ::...:|....|   ..|:|||::.|.|
  Fly    45 TGNIDPNVENMQTRAK------RKADHSPIKNDK---IKRSALGNLTNNVKIMTLHPAQDEEQSG 100

Human    53 ------SEQLQAKMPMKKEAKPSAT----------------------GKVIDK-----KLPKPLE 84
                  ::||||.|..||:...|..                      .||:||     ..|||..
  Fly   101 VGKKPTAQQLQALMDAKKQENLSVNVFGASKMTTRASSKVEDSVENCHKVLDKLEEALARPKPRP 165

Human    85 KV-------------------PMLVPV--PVSEPVPEPEPEPEPEPVK---------EEKL---- 115
            |.                   ||.:||  |.:..:..|: ....:||:         |:.|
  Fly   166 KAVPAAKKTVLGEVQLPAMPNPMQIPVLLPPTHNLAAPQ-VAAVKPVRRISNDFNKTEDSLYMSA 229

Human   116 --------------------------------SPEPILVDTASPSPMETSGCAPAEEDLCQAFSD 148
                                            .|:|:|:.....:|.:.....|..|:
  Fly   230 LEDVSSCDSMRLSGNFEAARRRSAKLQQKTEQQPQPLLLTLPETAPSQVVPIPPVPEE------- 287

Human   149 VILAVNDVDAEDGADPNLCSEYVKDIYAYLRQLEEEQAV---RPKYLLGREVTGNMRAILIDWLV 210
                |.|.|.::..||...|.|..||:.||:..|.|..:   .|:.:   .:|..||.:|:||:|
  Fly   288 ----VEDFDRKNWDDPFQVSHYAMDIFNYLKVREAEFPIADYMPRQI---HLTTWMRTLLVDWMV 345

Human   211 QVQMKFRLLQETMYMTVSIIDRFMQNNCVPKKMLQLVGVTAMFIASKYEEMYPPEIGDFAFVTDN 275
            :||..|.|..||:|:.|.|:|.::....:.|:.|||:|..|.|||.||:|..||.|.||.::.|.
  Fly   346 EVQETFELNHETLYLAVKIVDLYLCREVINKEKLQLLGAAAFFIACKYDERQPPLIEDFLYICDG 410

Human   276 TYTKHQIRQMEMKILRALNFGLGRPLPLHFLRRASKIGEVDVEQHTLAKYLMELTMLDYDMVHFP 340
            .|...::.:||.:.||.:.:.||.||...||||.::..:|.:...|||:|::||:::||..:.|.
  Fly   411 AYNHDELVRMERETLRVIKYDLGIPLSYRFLRRYARCAKVPMPTLTLARYILELSLMDYANISFS 475

Human   341 PSQIAAGAFCLALKI------LDNGEWTPTLQHYLSYTEESLLPVMQHLAKNVVMVNQGLTKH-- 397
            .||:|:.|..:||::      ||...||.||.:|..|.       :...|:.|..:|.||.:.
  Fly   476 DSQMASAALFMALRMHGGPGQLDKQTWTSTLIYYTGYQ-------LADFAEIVTALNAGLHRKPR 533

Human   398 ---MTVKNKYATSKHAKISTLPQL-NSALVQ 424
               .|::|||:.....:::.:|.| |..|.|
  Fly   534 ATIKTIRNKYSHKIFHEVAKVPLLTNQELFQ 564

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
CCNB1	NP_114172.1	Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	19..47		5/27 (19%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	93..116		6/67 (9%)
		CYCLIN_CCNB1_rpt1	167..295	CDD:410268	49/130 (38%)
		Interaction with CDK2	169..177		3/7 (43%)
		Interaction with CDK2	258..261		1/2 (50%)
		CYCLIN_CCNB1_rpt2	300..420	CDD:410272	41/131 (31%)
CycB3	NP_651303.2	CYCLIN_CCNB3_rpt1	290..431	CDD:410212	53/143 (37%)
		CYCLIN_CCNB3_rpt2	435..555	CDD:410214	39/126 (31%)