Protein Alignment CCNB1 and CycA

DIOPT Version :9

• Sequence 1: NP_114172.1
• Gene: CCNB1 / 891
• HGNCID: 1579
• Length: 433
• Species: Homo sapiens
• Sequence 2: NP_524030.2
• Gene: CycA / 39340
• FlyBaseID: FBgn0000404
• Length: 491
• Species: Drosophila melanogaster
• Alignment Length: 473
• Identity: 129/473 - (27%)
• Similarity: 207/473 - (43%)
• Gaps: 105/473 - (22%)

Human    12 NAENKAKINMAGAKRVPTAPAATSKPGLRPRTALGDIGNKVSEQLQAKMPMKKEAKPSATGKVI- 75
            |.||      .|.| :|.....|.:|       |..||.|..         |....|.|...|:
  Fly    12 NKEN------PGIK-IPAGVKNTKQP-------LAVIGGKAE---------KNALAPRANFAVLN 53

Human    76 -DKKLPKPLEKVPM---------------------LVPV-------PVSEPVPEPEPEP------ 105
             :..:|:|..||.:                     :|||       .|.|...:.:..|
  Fly    54 GNNNVPRPAGKVQVFRDVRNLNVDENVEYGAKKSNVVPVVEQFKTFSVYEDNNDTQVAPSGKSLA 118

Human   106 -----EPEPVK---------EEKLSPEPILV-DTASPSPMETSGCAPAEEDLCQAFSDVILAVND 155
                 |...||         :..|...|:.| |..||..::.|.....:.      ||:     .
  Fly   119 SLVDKENHDVKFGAGQKELVDYDLDSTPMSVTDVQSPMSVDRSILGVIQS------SDI-----S 172

Human   156 VDAEDGADPN----------------LCSEYVKDIYAYLRQLEEEQAVRPKYL-LGREVTGNMRA 203
            |..|.|..|.                ...:|..||..|.|:.|::...:|.|: ..::::.|||:
  Fly   173 VGTETGVSPTGRVKELPPRNDRQRFLEVVQYQMDILEYFRESEKKHRPKPLYMRRQKDISHNMRS 237

Human   204 ILIDWLVQVQMKFRLLQETMYMTVSIIDRFMQNNCVPKKMLQLVGVTAMFIASKYEEMYPPEIGD 268
            |||||||:|..:::|..||:|::|..:|||:....|.:..|||||..||:||:||||:||||:|:
  Fly   238 ILIDWLVEVSEEYKLDTETLYLSVFYLDRFLSQMAVVRSKLQLVGTAAMYIAAKYEEIYPPEVGE 302

Human   269 FAFVTDNTYTKHQIRQMEMKILRALNFGLGRPLPLHFLRRASKIGEVDVEQHTLAKYLMELTMLD 333
            |.|:||::|||.|:.:||..||:.|:|.|..|....|:...:.:.::..:...:..|:.||::::
  Fly   303 FVFLTDDSYTKAQVLRMEQVILKILSFDLCTPTAYVFINTYAVLCDMPEKLKYMTLYISELSLME 367

Human   334 YD-MVHFPPSQIAAGAFCLALKILDNGEWTPTLQHYLSYTEESLLPVMQHLAKNVVMVNQGLTKH 397
            .: .:.:.||.:::.:..||..||....|||.|:...:|..|.|..|:.||........:..|:.
  Fly   368 GETYLQYLPSLMSSASVALARHILGMEMWTPRLEEITTYKLEDLKTVVLHLCHTHKTAKELNTQA 432

Human   398 MTVKNKYATSKHAKISTL 415
            |  :.||....:.|::.:
  Fly   433 M--REKYNRDTYKKVAMM 448

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
CCNB1	NP_114172.1	Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	19..47		6/27 (22%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	93..116		6/42 (14%)
		Interaction with CDK2	169..177		3/7 (43%)
		Cyclin_N	173..298	CDD:278560	59/125 (47%)
		Interaction with CDK2	258..261		2/2 (100%)
		Cyclin_C	300..418	CDD:281044	26/117 (22%)
CycA	NP_524030.2	Cyclin_N	206..332	CDD:278560	59/125 (47%)
		Cyclin_C	334..450	CDD:281044	26/117 (22%)

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C165146222
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG5024
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D993640at2759
OrthoFinder	1	1.000	-	-		FOG0000121
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	1	0.900	-	-		OOG6_100199
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X94
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	7	6.650