Protein Alignment CCNB1 and CycJ

DIOPT Version :10

• Sequence 1: NP_114172.1
• Gene: CCNB1 / 891
• HGNCID: 1579
• Length: 433
• Species: Homo sapiens
• Sequence 2: NP_523903.1
• Gene: CycJ / 38428
• FlyBaseID: FBgn0010317
• Length: 386
• Species: Drosophila melanogaster
• Alignment Length: 277
• Identity: 69/277 - (24%)
• Similarity: 116/277 - (41%)
• Gaps: 46/277 - (16%)

Human   157 DAEDGADPNLCSEYVKDIYAYLRQLEEEQAVRPKYLLGREVTGNMRAILIDWLVQVQMKFRLLQE 221
            |.|..|..:..::|.:||:..:|  |:|.:.||.:.|..::  |.|..::..|.......:|.:.
  Fly    26 DVERLAKTHWLTDYARDIFLTMR--EQELSRRPLFYLSPQL--NERRRMLQLLKLATSAHKLSRC 86

Human   222 TMYMTVSIIDRFMQNNCVPKKMLQLVGVTAMFIASKYE--EMYPPEIGDFAFVTDNTYTKHQIRQ 284
            .:::.|..:|||:....:....|.||.:|.:.||::.|  :.:.|...:...:..|.||..:.:.
  Fly    87 ALHLAVYYMDRFVDYYKIRPDKLLLVAITCLHIAAQIENTDAFIPRYSEMNRLVKNAYTAFEYKA 151

Human   285 MEMKILRALNFGLGRP--------LPLHFLRRA------SKIGEVDVEQHT-------------- 321
            :|.|||..|||.|.||        ....||.|:      ..:.|.:...||
  Fly   152 VERKILCFLNFELIRPTTASFVELFACSFLTRSDFKNYIEMLDEYERNHHTQPYQRYISFEEMLS 216

Human   322 -LAKYLMELTMLDYDM-----VHFPPSQIAAGAFCLALKILDNGEWTPTLQHYLSYTEESLLPVM 380
             ||:.|  |.|.||.:     .:..||.:||.......::.....|:..|....||||.::.|.|
  Fly   217 ILAQLL--LRMADYTLYISRFANDLPSLLAAACIAAVRQVSGVRRWSEYLVGLTSYTEANVEPYM 279

Human   381 QHLAK----NVVMVNQG 393
            ..|..    :|:..:.|
  Fly   280 NVLTDYYYYHVIQTDYG 296

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
CCNB1	NP_114172.1	Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	19..47
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	93..116
		CYCLIN_CCNB1_rpt1	167..295	CDD:410268	33/129 (26%)
		Interaction with CDK2	169..177		3/7 (43%)
		Interaction with CDK2	258..261		1/4 (25%)
		CYCLIN_CCNB1_rpt2	300..420	CDD:410272	29/132 (22%)
CycJ	NP_523903.1	CYCLIN_CCNJ-like_rpt1	61..162	CDD:410231	24/102 (24%)
		CYCLIN_CCNJ-like_rpt2	167..282	CDD:410232	26/116 (22%)