Protein Alignment CCNB1 and CycB

DIOPT Version :10

• Sequence 1: NP_114172.1
• Gene: CCNB1 / 891
• HGNCID: 1579
• Length: 433
• Species: Homo sapiens
• Sequence 2: NP_726244.1
• Gene: CycB / 37618
• FlyBaseID: FBgn0000405
• Length: 530
• Species: Drosophila melanogaster
• Alignment Length: 473
• Identity: 166/473 - (35%)
• Similarity: 244/473 - (51%)
• Gaps: 63/473 - (13%)

Human     3 LRVT---RNSKINAEN---KAKINMAGAKRVPTAPAATSKPGLRPRTALGDIGNKVSEQLQAKMP 61
            |::|   ||:|...::   |..:...........|...::.|:........:.|:|..:...: |
  Fly    65 LKLTDALRNAKARVDSHWKKQPLGSTNGNGNGAVPPKVNEGGVSAFLRSNSVRNRVPTKTTVE-P 128

Human    62 MKKEAKPSATGKV-----------IDKK--------LPKPLEKVPMLVPVPVSEPVPEPEPEPEP 107
            .|...|.|::..|           :.||        |.||:..|..:...||:....|.|.:.|.
  Fly   129 TKVTVKSSSSENVNEPTLKREDSNLSKKSLTKLRAALAKPVMGVSGIRREPVAVSRKEAETKKEL 193

Human   108 EPVKEEKLSPE------PIL----VDTASPSPMETSGCAPAEEDLCQAFSDVILA-VNDVDAEDG 161
            ...|::.|..:      |::    ..|.:.|.|.|:          .:.|...|| :.|:||.|.
  Fly   194 PETKKDSLEVKKDATRMPLIRGNSAVTTTTSTMPTT----------MSLSSKRLAGIEDIDANDK 248

Human   162 ADPNLCSEYVKDIYAYLRQLEEEQAVRPKYLLG-REVTGNMRAILIDWLVQVQMKFRLLQETMYM 225
            .:..|.||||.|||.||.|:|.||.:...:|.| :||:..|||:||||:.:|.::|.|..||..:
  Fly   249 ENLVLVSEYVNDIYDYLYQVELEQPIHKDHLAGQKEVSHKMRAVLIDWINEVHLQFHLAAETFQL 313

Human   226 TVSIIDRFMQ-NNCVPKKMLQLVGVTAMFIASKYEEMYPPEIGDFAFVTDNTYTKHQIRQMEMKI 289
            .|:||||::| .....:..||||||||:|||:||||::||.||||.|:||:|||..||||||::|
  Fly   314 AVAIIDRYLQVVKDTKRTYLQLVGVTALFIATKYEELFPPAIGDFVFITDDTYTARQIRQMELQI 378

Human   290 LRALNFGLGRPLPLHFLRRASKIGEVDVEQHTLAKYLMELTMLDYDMVHFPPSQIAAGAFCLALK 354
            .:|::..|.||||:|||||.||....:.|.||::||.:||..:||:|..:.||:|||.:..|:|.
  Fly   379 FKAIDCNLSRPLPIHFLRRYSKAAGAEDEHHTMSKYFIELASVDYEMATYRPSEIAAASLFLSLH 443

Human   355 ILDNG-----------EWTPTLQHYLSYTEESLLPVMQHLAKNVVMVNQGLTKHMTVKNKYATSK 408
            :| ||           .|||||..|..|:...|.|:.:.:||......|...|  .:.|||..||
  Fly   444 LL-NGNHRAGTGFNDRHWTPTLTFYSRYSAAHLRPITRLIAKLARDAPQAKLK--AIYNKYQGSK 505

Human   409 HAKISTLPQLNSALVQDL 426
            ..||:...:|..||:..:
  Fly   506 FQKIALRTELTGALMDSI 523

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
CCNB1	NP_114172.1	Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	19..47		2/27 (7%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	93..116		6/22 (27%)
		CYCLIN_CCNB1_rpt1	167..295	CDD:410268	70/129 (54%)
		Interaction with CDK2	169..177		6/7 (86%)
		Interaction with CDK2	258..261		2/2 (100%)
		CYCLIN_CCNB1_rpt2	300..420	CDD:410272	51/130 (39%)
CycB	NP_726244.1	CYCLIN_CCNB1-like_rpt1	254..384	CDD:410211	70/129 (54%)
		CYCLIN_CCNB1-like_rpt2	389..509	CDD:410213	48/122 (39%)