DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CPNE1 and CG8945

DIOPT Version :9

Sequence 1:	NP_003906.2	Gene:	CPNE1 / 8904	HGNCID:	2314	Length:	542	Species:	Homo sapiens
Sequence 2:	NP_573190.1	Gene:	CG8945 / 32693	FlyBaseID:	FBgn0030815	Length:	1430	Species:	Drosophila melanogaster

Alignment Length:	212	Identity:	40/212 - (18%)
Similarity:	67/212 - (31%)	Gaps:	97/212 - (45%)

- Green bases have known domain annotations that are detailed below.

Human   162 KSDPFLEFFRQGDGKWHLVYRSEVIKNNLNPTWKRFSVPVQHFCGGNPSTPIQVQCSDYDSDG-- 224
            ||:..:||.|                   |.||  :.:||.     ||             ||
  Fly  1193 KSNEDVEFIR-------------------NTTW--YIMPVL-----NP-------------DGYA 1218

Human   225 -SHDLIGTFHTSLAQLQAVPAEFECIHPEKQQKKKSYKNSGTIRVKICRVETEYSFLDYVMGGCQ 288
             ||:....:..|.:|.|..|.                  ||.:       ::..::|....|..:
  Fly  1219 YSHEYDRFWKKSRSQHQTPPP------------------SGLL-------DSAMTWLQQKRGPDK 1258

Human   289 INFTVGVD-----FTGSNGDPSSPDSLHYLSPT--------GVNEYLM----------ALWSVGS 330
            :.:.|.:|     ..|..|...:|.:..|..|.        .|:|:||          :|.:.|.
  Fly  1259 VCYGVDLDRNWLYHWGKRGSSKAPCNEFYAGPAPFSEPETKAVSEFLMDYRTQIKLYISLQAYGQ 1323

Human   331 VV-------QDYDSDKL 340
            |:       ..::|::|
  Fly  1324 VISYPVKANSTFNSERL 1340

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CPNE1	NP_003906.2	C2A_Copine	11..129	CDD:176013
		C2B_Copine	143..250	CDD:176012	20/90 (22%)
		vWA_copine_like	256..514	CDD:238736	20/115 (17%)
CG8945	NP_573190.1	Propep_M14	988..1058	CDD:280416
CG8945	NP_573190.1	M14_CP_A-B_like	1089..1430	CDD:199844	40/212 (19%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	1	0.950	-	0	Normalized mean entropy	S4063
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	1	0.950