Protein Alignment CCNA2 and CycB3

DIOPT Version :9

• Sequence 1: NP_001228.2
• Gene: CCNA2 / 890
• HGNCID: 1578
• Length: 432
• Species: Homo sapiens
• Sequence 2: NP_001262934.1
• Gene: CycB3 / 42971
• FlyBaseID: FBgn0015625
• Length: 575
• Species: Drosophila melanogaster
• Alignment Length: 469
• Identity: 133/469 - (28%)
• Similarity: 208/469 - (44%)
• Gaps: 105/469 - (22%)

Human    15 GSALLALQQTALQEDQ-ENINP-----EKAAPVQQPRTRAALAVLKSGNPRGLAQQQRPKTRRVA 73
            |::.:..:.::..||. ||.:.     |:|....:||.:|..|..|:    .|.:.|.|....
  Fly   128 GASKMTTRASSKVEDSVENCHKVLDKLEEALARPKPRPKAVPAAKKT----VLGEVQLPAMPN-- 186

Human    74 PLKDLPVNDEHVTVPPWKANSKQPAFTIHVDEAEKEAQKKPAESQKI-----EREDAL---AFNS 130
            |:: :|     |.:||           .|...|.:.|..||.  ::|     :.||:|   |...
  Fly   187 PMQ-IP-----VLLPP-----------THNLAAPQVAAVKPV--RRISNDFNKTEDSLYMSALED 232

Human   131 AISLPGPRKPLVPLDYPMDGSFES-----------------------PHTMDMSIILEDEKPVSV 172
            ..|....|         :.|:||:                       |.|....::.....|..|
  Fly   233 VSSCDSMR---------LSGNFEAARRRSAKLQQKTEQQPQPLLLTLPETAPSQVVPIPPVPEEV 288

Human   173 N-----------EVPDYHEDIHTYLREMEVKCKPKVGYMKKQPDITNSMRAILVDWLVEVGEEYK 226
            .           :|..|..||..||:..|.:. |...||.:|..:|..||.:||||:|||.|.::
  Fly   289 EDFDRKNWDDPFQVSHYAMDIFNYLKVREAEF-PIADYMPRQIHLTTWMRTLLVDWMVEVQETFE 352

Human   227 LQNETLHLAVNYIDRFLSSMSVLRGKLQLVGTAAMLLASKFEEIYPPEVAEFVYITDDTYTKKQV 291
            |.:|||:|||..:|.:|....:.:.||||:|.||..:|.|::|..||.:.:|:||.|..|...::
  Fly   353 LNHETLYLAVKIVDLYLCREVINKEKLQLLGAAAFFIACKYDERQPPLIEDFLYICDGAYNHDEL 417

Human   292 LRMEHLVLKVLTFDLAAPTVNQFLTQYFLHQQPANC-KVE----SLAMFLGELSLIDADPY--LK 349
            :|||...|:|:.:||..|...:||.:|      |.| ||.    :||.::.||||:|   |  :.
  Fly   418 VRMERETLRVIKYDLGIPLSYRFLRRY------ARCAKVPMPTLTLARYILELSLMD---YANIS 473

Human   350 YLPSVIAGAAFHLALYTVTG------QSWPESLIRKTGYTLESLKPCLMDLHQTYLKAPQHAQQS 408
            :..|.:|.||..:||....|      |:|..:||..|||.|......:..|:....:.|:...::
  Fly   474 FSDSQMASAALFMALRMHGGPGQLDKQTWTSTLIYYTGYQLADFAEIVTALNAGLHRKPRATIKT 538

Human   409 IREKYKNSKYHGVS 422
            ||.||.:..:|.|:
  Fly   539 IRNKYSHKIFHEVA 552

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
CCNA2	NP_001228.2	Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	26..45		6/24 (25%)
		Cyclin_N2	28..166	CDD:406812	36/174 (21%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	55..75		3/19 (16%)
		CYCLIN_CCNA2_rpt1	175..305	CDD:410264	53/129 (41%)
		CYCLIN_CCNA2_rpt2	309..419	CDD:410267	37/122 (30%)
CycB3	NP_001262934.1	Cyclin_N	308..433	CDD:278560	52/125 (42%)
		Cyclin_C	435..555	CDD:281044	39/127 (31%)

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG5024
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D993640at2759
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X94
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	4	3.820