Protein Alignment ACTN3 and Dys

DIOPT Version :9

• Sequence 1: NP_001245300.2
• Gene: ACTN3 / 89
• HGNCID: 165
• Length: 944
• Species: Homo sapiens
• Sequence 2: NP_001036722.1
• Gene: Dys / 42327
• FlyBaseID: FBgn0260003
• Length: 3598
• Species: Drosophila melanogaster
• Alignment Length: 1111
• Identity: 233/1111 - (20%)
• Similarity: 395/1111 - (35%)
• Gaps: 369/1111 - (33%)

Human    92 QTFTAWCNSHLRKAG-TQIENIEEDFRNGLKLMLLLEVISGERLPRPDKGKMRFHKIANVNKALD 155
            :|||.|.||||.... |.::::..|.|:|.:|:.||..::...| :|:||:||.|.|.|:||.:.
  Fly    16 KTFTKWINSHLIDTQCTPVKDLFLDLRDGHRLLALLSTLTQTNL-KPEKGRMRVHHINNLNKVIT 79

Human   156 FIASKGVKLVSIGAEEIVDGNLKMTLGMIWTIILRFAIQDI--SVEETSAKEGLLLWCQRKTAPY 218
            .|...|||||:|.:::||.||.|:|||:||.|.|.|..|.:  |......::.||.|.::.|.|:
  Fly    80 EIQQHGVKLVNISSDDIVGGNAKLTLGLIWLIALEFNGQHLVKSHSSNGVEKSLLAWARQYTEPH 144

Human   219 RNVNVQNFHTSWKDGLALCALIHRHRPDLIDYAKLRKDDPIGNLNTAFEVAEKYLDIPKMLDAED 283
             .:.:.:|.:||.||.|...::..|..:|...|.|:: ..:..|:.||::|.::..|.|:|||||
  Fly   145 -GLQLNDFSSSWSDGRAFLMILDAHVEELNLQAALQQ-HALKRLHLAFDLAHRHFKIEKLLDAED 207

Human   284 IVNTPKPDEKAIMTYVSCFYHAFAG-------AEQAE---------------------------- 313
             |:|.|||.|:|..||.|.|||...       .||.|
  Fly   208 -VHTHKPDNKSIQMYVMCLYHAMESMRTRQQEQEQDEGQDQDPGRVPCTSITDLDEVPLDNDQTS 271

Human   314 -----------------------------TAANRICK----------VLAVNQENEKLM------ 333
                                         ||.|...:          ||.:..|:|:|:
  Fly   272 LGLYTSDSAGSMEQRSSGELKTHSMRPLSTATNASVEISGYQSALEAVLTLLLEDEQLLSQNLPD 336

Human   334 --------------EEYEKLASELLEWIRRTVPWLENRVGEPSMSAMQRKLEDFRDYRRLHKPPR 384
                          |.:....:|..|::...:....|.:.|...:......||..:.|
  Fly   337 PQDFQTAKLQFHENESFMLKLTEHQEYVGEALEEGSNLINESQKAGAGLSQEDQNEVR------- 394

Human   385 IQEKCQLEINFNTLQ-----------------TKLRLSHRPAFMPSEGKLVSDIANAWRGLEQVE 432
             |:...|...:.||:                 .|.:|.....|:.|....:|.:::....||:.|
  Fly   395 -QQMVLLNERWETLRLRALDVQAKILMRLAEFQKQKLEQLRQFLTSVEDRISHMSDIGPTLEEAE 458

Human   433 KGYEDWLLSEIRRLQ----RLQHLAEKFR------------------QKASLHEAWTRGKEEMLS 475
            |     .|.|.::|:    ..|.|.:...                  :.::|.|.|:    .::.
  Fly   459 K-----QLLEAQKLKADLSEQQELVDSLSSMVVIVNDTSGNFNDLEDRLSALGERWS----HVVK 514

Human   476 QRDYDSALLQEVRALLRRHEAFESDLAAHQDR-VEHIAALAQELNELDY---------HEAASVN 530
            ..|.....||:.:.:.|..:|.|.||...:.| |..:..:.|.:|||:|         .....:.
  Fly   515 WSDLRKEKLQQYKCISRWLDAREQDLKLMESRDVTDVGGITQRINELNYCAKDLLELQRYLIDLR 579

Human   531 SRCQAICDQWDNLGTLT----QKRRDALERMEKLLET----IDRLQLEFARRAAPFNN------- 580
            ....|.....|:.|...    :...|.|:.:::::|.    |:.....|.|..|.:::
  Fly   580 QMVAATLQDGDDKGERVLIQLESYEDRLDALKQIVEVQTVRIETKGFNFGRDRASYDDSRVVRPE 644

Human   581 -WLDGAV------EDLQDVWLVHSVEETQSLLTAHDQFKATLPEADRERGAIMGIQGEIQKI--- 635
             |:|..:      :|.|:....|.:...:..|...|.|.|.........|.:..::.::|::
  Fly   645 GWVDYQMIIRFGEDDSQEDDDEHDLASKKRKLRNADNFNALENHIMEHFGYVQEVEQKLQQLQRQ 709

Human   636 -----C------QTYGLRPCSTNPYITLSPQDINTKWDMVRKLVPSCD------QTLQEELARQQ 683
                 |      |....|.|.|.|.:              :||...|:      ..|.||...:|
  Fly   710 SLRQQCELLKELQAENSRRCGTLPEL--------------KKLYEVCELEDPSRNLLLEETHIKQ 760

Human   684 VNER---LRRQFAAQ-----------------------------------ANAIGPWIQAKVEEV 710
            :.:|   |.::.::|                                   .:|.|..::.::..:
  Fly   761 LEQRYANLSQKLSSQQSESHTLLAKEKYYNSLTGFKLVLADSRDWYKQHAGSASGNELEQRLSHM 825

Human   711 GRLAAGLA-------------------------------------------GSLEEQMAGLRQQE 732
            ..||:.::                                           .||..|:..::...
  Fly   826 ESLASEISEAKTATEELDDNLIEWKQDFGLFYDSWHDMKQALQALIQQRGGESLSRQLKQIQDFV 890

Human   733 QNIINYKTNIDRL----EGDH---QLLQE----SLVFDN--KHTVYSMEHIRVGW----EQLLTS 780
            ..:.|.|..:..|    |..|   |||.|    .|.:||  ||.:  .|.::..|    |||...
  Fly   891 TKVSNQKVRVSNLEVMQEQQHFLNQLLDEMESLRLTYDNIPKHLI--GEELQTAWNRLPEQLNER 953

Human   781 IARTINEVENQVLTRDAKGLSQEQLNEFRASFNHF--------DRKQNGMMEPDDFRACLISMGY 837
            :.:....:||              ||.|.|.:|..        |.|.||   .|.      :...
  Fly   954 VIKQTTAIEN--------------LNHFAAEYNAIIAMLRSAADSKLNG---SDG------ASSQ 995

Human   838 DLGEVEFARIMTMVDPNAAGVVTFQAFIDFMTRETAETDTTEQVVASFKILAGDKNYITPEELRR 902
            ||.::|       :|     |::.:.|.:.:.:| ||....|.:.:..:.|  :..|...|::.|
  Fly   996 DLRKLE-------ID-----VISARNFSEILIKE-AEPAQKESLQSQIRAL--NTLYDQVEQVHR 1045

Human   903 ELPAKQ 908
            |...:|
  Fly  1046 EKKEQQ 1051

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
ACTN3	NP_001245300.2	CH	90..187	CDD:278723	43/95 (45%)
		CH	202..307	CDD:237981	39/104 (38%)
		Spectrin	331..440	CDD:278843	22/145 (15%)
		SPEC	452..679	CDD:238103	51/296 (17%)
		SPEC	570..790	CDD:238103	56/351 (16%)
		EFh	807..869	CDD:238008	14/69 (20%)
		EF-hand_7	809..868	CDD:290234	13/66 (20%)
		EFhand_Ca_insen	874..940	CDD:285885	8/35 (23%)
Dys	NP_001036722.1	CH	13..111	CDD:278723	43/95 (45%)
		CH	129..225	CDD:278723	35/98 (36%)
		SPEC	312..525	CDD:238103	36/229 (16%)
		SbcC	<325..957	CDD:223496	110/664 (17%)
		Smc	<816..1591	CDD:224117	52/276 (19%)
		SPEC	1174..1365	CDD:238103
		SPEC	1289..1485	CDD:295325
		SPEC	2369..2576	CDD:238103
		SPEC	2477..2714	CDD:238103
		WW	2852..2882	CDD:238122
		EF-hand_2	2883..2997	CDD:286194
		EF-hand_3	3001..3100	CDD:286195
		ZZ_dystrophin	3110..3158	CDD:239074

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	1	0.910