DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment PRPF4B and KNS1

DIOPT Version :9

Sequence 1:	NP_003904.3	Gene:	PRPF4B / 8899	HGNCID:	17346	Length:	1007	Species:	Homo sapiens
Sequence 2:	NP_013081.1	Gene:	KNS1 / 850641	SGDID:	S000003942	Length:	737	Species:	Saccharomyces cerevisiae

Alignment Length:	729	Identity:	163/729 - (22%)
Similarity:	263/729 - (36%)	Gaps:	221/729 - (30%)

- Green bases have known domain annotations that are detailed below.

Human   474 GRRSRSRLR-RRSRSRGGRRRRSRSKVKEDKFK----GSLSEGMKVEQESSSDDNLED-FDVEEE 532
            |.|.|||.. ..|.:.|.....|.:|...|.|:    ..|.:.|...|.|...|||.: .|:.:.
Yeast     8 GTRKRSRANMNNSTTTGPANNTSSNKTFLDNFEETRTNKLLDEMFARQNSFLTDNLRNSLDLNQA 72

Human   533 DEEALIEQRRIQRQAIVQKYKYLAEDSNMSVPSEP---------SSPQSSTRTRSPSPDDILERV 588
            |..  :..|:.|.|.      :|..::.:.:..||         |:..:|:|....:.|||:
Yeast    73 DNP--LRPRQHQHQL------FLDNENAIELDEEPRIINTTINNSNNHNSSRVDEDADDDII--- 126

Human   589 AADVKE----YERENVDTFEASVKAKHNLMTVEQNNG------------------SSQKKLLAPD 631
              .:||    :....:....:|:...:|::| ..|.|                  ..|:.:..|.
Yeast   127 --FIKEQPIQFSSPLILPSSSSINNNNNIVT-SNNPGCGTAATSNSTYITTPKKFKKQRTISLPQ 188

Human   632 MFTESDDMFAAYFD----------------------------------SARLRAAGIGKDFKENP 662
            :........:.||:                                  :..|..|.....|...|
Yeast   189 LPLSKLSYQSNYFNVPDQTNAIVPRVTQTENELLHLTGSCAKTLEGNKAVNLTIAHSTSPFSNPP 253

Human   663 ---------NL-----------------------RDNW-TDAEGYYRVNIGEVLDK--RYNVYGY 692
                     ||                       :.|: ||.:|:|.....::...  |:.|...
Yeast   254 AQIASLPQSNLKKQIGSSLRKFTSNGSSESASSNKSNFKTDKDGHYVYQENDIFGSGGRFVVKDL 318

Human   693 TGQGVFSNVVRARDNARANQEVAVKIIRNNELMQKTGLKELEFLKKLNDADPDDKFHCLRLFRHF 757
            .|||.|..|::..||......||||:||..:..::....||..|:.:.:.||..:|.||.|...|
Yeast   319 LGQGTFGKVLKCIDNKYEPNYVAVKVIRAVDRYREAAKTELRILQTILNNDPQGQFQCLLLRECF 383

Human   758 YHKQHLCLVFEPLSMNLREVLKKYG--KDVGLHIKAVRSYSQQLFLALKLLKRCNILHADIKPDN 820
            .:|.|:|||.:....::.:.:...|  :..|.||:|:   ::||..::..|....|:|.|:||:|
Yeast   384 DYKNHICLVTDLYGRSIYDFMCSNGIARFPGSHIQAI---ARQLIRSVCFLHDLGIIHTDLKPEN 445

Human   821 ILVNES---------KTI----------------------LKLCDFGSASHVADNDITPYLVS-R 853
            ||:.:.         ||:                      :|:.|||||  :...:..|.::| |
Yeast   446 ILICDETHIAQKLPLKTVQSLSKRRREASKGKRKILKNPEIKIIDFGSA--IFHYEYHPPVISTR 508

Human   854 FYRAPEIIIGKSYDYGIDMWSVGCTLYELYTGKILFPGKTNNHMLKLAMDLKG-KMPNKMIRKGV 917
            .||||||::|..:.:..|:||:.|.|.||..|:.|:|...|...:.:...:.| ..|..:|.|..
Yeast   509 HYRAPEIVLGLGWSFPCDIWSIACVLVELVIGESLYPIHENLEHMAMMQRINGTPFPTDIIDKMF 573

Human   918 FKDQH----FDQNLNFMYIE-VDKVTER----EKVTVMSTINPTKDLLADLIGCQRL-------- 965
            :|.:|    ...:||...|: .|:.|..    ||.....||...|.:...|..|.||
Yeast   574 YKSKHKLGNSPSDLNSTVIKHFDRKTLSLQWPEKNKRGDTITTEKSMKRVLQSCDRLDIYISKVL 638

Human   966 ---------------PEDQ----------RKKVHQLK-------------------DLLDQILML 986
                           ||..          :::.|...                   |||.::...
Yeast   639 KQDYGDSLSINWNLPPEKNWSLINSKLAWKRQTHSSSSSTTDELDKETFLFWYWFIDLLRKMFEF 703

Human   987 DPAKRISINQALQH 1000
            ||.|||:...||.|
Yeast   704 DPTKRITAKDALDH 717

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
PRPF4B	NP_003904.3	Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1..99
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	140..533		19/64 (30%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	559..583		5/32 (16%)
		STKc_PRP4	686..1003	CDD:271037	109/411 (27%)
		S_TKc	694..1003	CDD:214567	107/403 (27%)
KNS1	NP_013081.1	PKc_CLK	298..720	CDD:271036	110/425 (26%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG0667
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	2	1.810