DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment PRPF4B and prpf4b

DIOPT Version :9

Sequence 1:	NP_003904.3	Gene:	PRPF4B / 8899	HGNCID:	17346	Length:	1007	Species:	Homo sapiens
Sequence 2:	XP_002936474.1	Gene:	prpf4b / 779480	XenbaseID:	XB-GENE-988306	Length:	995	Species:	Xenopus tropicalis

Alignment Length:	1011	Identity:	833/1011 - (82%)
Similarity:	910/1011 - (90%)	Gaps:	24/1011 - (2%)

- Green bases have known domain annotations that are detailed below.

Human     4 AETQSLREQPEMEDAN-SEKSINEENGEVSEDQSQ--NKHSRHKKKKHKHRSKHKKHKHSSEEDK 65
            |:..|.....|||||: ||:|..||||||||::.|  ||||:|||||||||||||||||||||:|
Frog     2 ADVGSELRDAEMEDADTSERSGVEENGEVSEEEQQPLNKHSKHKKKKHKHRSKHKKHKHSSEEEK 66

Human    66 DKKHKHKHKHKKHKRKEIIDASDKEGMSPAKRTKLDDLALLEDLEKQRALIKAELDNELMEGKVQ 130
            ||||||||||||||||:..:. :||.:||.||.||||.|||||||||||:|||||||||||||||
Frog    67 DKKHKHKHKHKKHKRKDSGNI-EKEDVSPTKRAKLDDFALLEDLEKQRAMIKAELDNELMEGKVQ 130

Human   131 SGMGLILQGYESGSEEEGEIHEKARNGNRSSTRSSSTKGKLELVDNKITTKKRSKSRSKERTRHR 195
            ||||||||||.|||||||||:||||||.::|  .|:.|||.:|| :|..:|:||.|:::|:.:|:
Frog   131 SGMGLILQGYNSGSEEEGEINEKARNGKKTS--KSNAKGKHDLV-SKTASKRRSTSKTEEKAKHK 192

Human   196 SDKKKSKGGIEIVKEKTTRSKSKERKKSKSPSKRSKSQDQARKSKSPTLRRRSQEKIGKARSPTD 260
            |:|||:|...|.||||....|||||:|||||:|||||:||.|  :||.|||:|.||..|.:||.
Frog   193 SEKKKNKTISEAVKEKIPSGKSKERRKSKSPAKRSKSEDQPR--RSPALRRQSPEKNIKTKSPQ- 254

Human   261 DKVKIEDKSKSKDRKKSPIINESRSRDRGKKSRSPVDLRGKSKDRRSRSKERKSKRSETDKEKKP 325
                 |::.||:||||||:.:||:||:|.|||:|||..|.|||:|||:|||:|.:||::|:::||
Frog   255 -----EERMKSRDRKKSPVASESKSRERTKKSKSPVSRRSKSKERRSKSKEKKPRRSDSDRDRKP 314

Human   326 IKSPSKDASSGKENRSPSRRPGRSPKRRSLSPKPRDKS-RRSRSPLLNDRRSKQSKSPSRTLSPG 389
            :||||||||||||||||.|||.||||.||||||.||:: |.||||.::||:|||  ||.|..||.
Frog   315 LKSPSKDASSGKENRSPGRRPARSPKARSLSPKQRDRAMRHSRSPPVHDRKSKQ--SPPRIQSPT 377

Human   390 RRAKSRSLERKRREPERRRLSSPRTRPRDDILSRRERSKDASPINRWSPTRRR-SRSPIRRRSRS 453
            |||||:|:||||||||||||||||:|.|:|..:|.:|:|:||| :||||:||| ||||.||||||
Frog   378 RRAKSKSVERKRREPERRRLSSPRSRTREDTAARHDRAKEASP-SRWSPSRRRPSRSPARRRSRS 441

Human   454 PLRRSRSPRRRSRSPRRRDRGRRSRSRLRRRSRSRGG--RRRRSRSKVKEDKFKGSLSEGMKVEQ 516
            ||||||||||||||..||:|||||||||||||.||||  ||||||||.||||||||||||||:||
Frog   442 PLRRSRSPRRRSRSLHRRERGRRSRSRLRRRSHSRGGRNRRRRSRSKDKEDKFKGSLSEGMKIEQ 506

Human   517 ESSSDDNLEDFDVEEEDEEALIEQRRIQRQAIVQKYKYLAEDSNMSVPSEPSSPQSSTRTRSPSP 581
            | ||||||||||||||||||||||||.||.||||||:|:.|||||||||||||||||||:|||||
Frog   507 E-SSDDNLEDFDVEEEDEEALIEQRRQQRLAIVQKYRYINEDSNMSVPSEPSSPQSSTRSRSPSP 570

Human   582 DDILERVAADVKEYERENVDTFEASVKAKHNLMTVEQNNGSSQKKLLAPDMFTESDDMFAAYFDS 646
            ||||||||||||||||||:||||||||||.|||| |||||:.|||||||||||||||||||||||
Frog   571 DDILERVAADVKEYERENIDTFEASVKAKQNLMT-EQNNGAMQKKLLAPDMFTESDDMFAAYFDS 634

Human   647 ARLRAAGIGKDFKENPNLRDNWTDAEGYYRVNIGEVLDKRYNVYGYTGQGVFSNVVRARDNARAN 711
            ||||||||||||||||||||||||:||||||||||:|:||||||||||||||||||||||.||||
Frog   635 ARLRAAGIGKDFKENPNLRDNWTDSEGYYRVNIGEILEKRYNVYGYTGQGVFSNVVRARDMARAN 699

Human   712 QEVAVKIIRNNELMQKTGLKELEFLKKLNDADPDDKFHCLRLFRHFYHKQHLCLVFEPLSMNLRE 776
            |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
Frog   700 QEVAVKIIRNNELMQKTGLKELEFLKKLNDADPDDKFHCLRLFRHFYHKQHLCLVFEPLSMNLRE 764

Human   777 VLKKYGKDVGLHIKAVRSYSQQLFLALKLLKRCNILHADIKPDNILVNESKTILKLCDFGSASHV 841
            |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
Frog   765 VLKKYGKDVGLHIKAVRSYSQQLFLALKLLKRCNILHADIKPDNILVNESKTILKLCDFGSASHV 829

Human   842 ADNDITPYLVSRFYRAPEIIIGKSYDYGIDMWSVGCTLYELYTGKILFPGKTNNHMLKLAMDLKG 906
            |||||||||||||||||||||||.||||||||||||||||||.||||||||||||||||||||||
Frog   830 ADNDITPYLVSRFYRAPEIIIGKMYDYGIDMWSVGCTLYELYNGKILFPGKTNNHMLKLAMDLKG 894

Human   907 KMPNKMIRKGVFKDQHFDQNLNFMYIEVDKVTEREKVTVMSTINPTKDLLADLIGCQRLPEDQRK 971
            ||||||||||||||||||.||||||||||||||||||||||||||||||||||||||||||||||
Frog   895 KMPNKMIRKGVFKDQHFDANLNFMYIEVDKVTEREKVTVMSTINPTKDLLADLIGCQRLPEDQRK 959

Human   972 KVHQLKDLLDQILMLDPAKRISINQALQHAFIQEKI 1007
            |||||||||||||||||||||||||||||.||||||
Frog   960 KVHQLKDLLDQILMLDPAKRISINQALQHPFIQEKI 995

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
PRPF4B	NP_003904.3	Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1..99		67/97 (69%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	140..533		270/396 (68%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	559..583		22/23 (96%)
		STKc_PRP4	686..1003	CDD:271037	311/316 (98%)
		S_TKc	694..1003	CDD:214567	303/308 (98%)
prpf4b	XP_002936474.1	PTZ00108	<104..327	CDD:240271	150/233 (64%)
		SF-CC1	225..>351	CDD:273721	85/133 (64%)
		STKc_PRP4	674..991	CDD:271037	311/316 (98%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	1	1.000	971	1.000	Domainoid score	I721
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	1593	1.000	Inparanoid score	I1218
NCBI	1	1.000	-	-
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D108923at7742
OrthoFinder	1	1.000	-	-		FOG0003592
OrthoInspector	1	1.000	-	-		oto156171
Panther	1	1.100	-	-	LDO	PTHR24056
Phylome	0	0.000	Not matched by this tool.
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R996
SonicParanoid	1	1.000	-	-		X2065
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	10	10.190