DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment PRPF4B and prpf4bb

DIOPT Version :9

Sequence 1:	NP_003904.3	Gene:	PRPF4B / 8899	HGNCID:	17346	Length:	1007	Species:	Homo sapiens
Sequence 2:	NP_998614.1	Gene:	prpf4bb / 406758	ZFINID:	ZDB-GENE-040426-2799	Length:	1010	Species:	Danio rerio

Alignment Length:	1048	Identity:	704/1048 - (67%)
Similarity:	809/1048 - (77%)	Gaps:	91/1048 - (8%)

- Green bases have known domain annotations that are detailed below.

Human     5 ETQSLREQPEMEDANSEKSINEENGEVS-EDQSQ---------------NKH--SRHKKKKHKHR 51
            :::.|...||..::..:....:|||::| ||:.:               :||  |:|||||||||
Zfish     9 QSKRLNNGPENLESPQKSGNEDENGDISGEDEEEGEEEVEMNGEKQDISSKHHSSKHKKKKHKHR 73

Human    52 SKHKKHKHSSEEDKDKKHKHKHKHKKHKRKE-----IIDASDKEGMSPAKRTKLDDLALLEDLEK 111
            ||||||||:|||||::|.||:.|||||||||     .|....::|........|||.||||||||
Zfish    74 SKHKKHKHASEEDKNRKRKHRRKHKKHKRKEEASSSAISRKAEDGSMLLSSANLDDKALLEDLEK 138

Human   112 QRALIKAELDNELMEGKVQSGMGLILQGYESGSEEEGEIHEKARNG----NRSSTRSSSTKGKL- 171
            ||||||||||:::|.||||||||||||||.|||||:.| .::||||    |.|..|:.|.:.::
Zfish   139 QRALIKAELDSQMMGGKVQSGMGLILQGYNSGSEEDEE-RQRARNGEQRQNSSGGRTRSPRDQIG 202

Human   172 -------ELVDNKITTKKRSKSRSKERT-RHRSDKKKSKGGIEIVKEKTTRSKSKERKKSKSPSK 228
                   :|..:|.:.|::|.|.|:||. |....::.:|...|.|||   ||||||:|:|:|
Zfish   203 GMGRSRRDLDTSKPSAKQQSHSHSRERAGRDSKLERATKSAKETVKE---RSKSKEKKRSRS--- 261

Human   229 RSKSQDQARKSKSPTLRRRSQEKIGKARSPTDDKVKIEDKSKSKDRKKSPIINESRSRDRGKKSR 293
            |.||:|:.:||:||::||.|.:     |.|        |:....||:.||.::|.|.:.|.:...
Zfish   262 RDKSKDRGKKSQSPSIRRHSAD-----RKP--------DQKGRPDRRSSPHMDEKREQVRQRSDS 313

Human   294 SPVDLRGKSKDRRSRSKERKSKRSETDKEKKPIKSPSKDASSGKENRSPSRRPGRSPK-RRSLSP 357
            .    .|||:.:.|:..:... |||.|:||:|.||||||.|||||||||.:||..||: |||.||
Zfish   314 Q----GGKSQSQGSKDGQNVG-RSENDREKRPGKSPSKDPSSGKENRSPQQRPALSPQHRRSSSP 373

Human   358 KPRDKSRRSRSPLLN--DRRSKQSKSPSRTLSPGRRAKSRSLERKRREPERRRLSSPRTRPRDDI 420
            :.||  |:|..|..:  ||.||.|.||||..|..|||:|||.||:|..|.|:||       |.|.
Zfish   374 RHRD--RQSNQPRFSSVDRSSKLSHSPSRNRSLARRARSRSNERRRDSPSRKRL-------RVDG 429

Human   421 LSRRERSKDASPINRWSPTRRRSRSPIRRRSRSPLRRSR-SPRRRSRSPRRR---DRGRRSRSRL 481
            :.   ||::.:|:.     ||.||||:||||.||.|:|| |||||||||:||   :|.|..|.|.
Zfish   430 VG---RSRETTPVR-----RRVSRSPLRRRSVSPRRQSRSSPRRRSRSPQRRRSVERDRFGRPRP 486

Human   482 RR-RSRSRGGRRRRSRSKVKEDKFKGSLSEGMKVEQESSSDDNLEDFDVEEEDEEALIEQRRIQR 545
            || .||:|..||||||.   |||||||||||||.:|||||::.:||||.|||||||||||||.||
Zfish   487 RRSTSRNRDRRRRRSRD---EDKFKGSLSEGMKADQESSSEEVMEDFDAEEEDEEALIEQRRQQR 548

Human   546 QAIVQKYKYLAEDSNM-SVPSEPSSPQSSTRTRSPSPDDILERVAADVKEYERENVDTFEASVKA 609
            .|||||||...||||: |:.|||||||||:|:||||||||||||||||||||||||::|||::||
Zfish   549 LAIVQKYKAGNEDSNLGSMASEPSSPQSSSRSRSPSPDDILERVAADVKEYERENVNSFEANIKA 613

Human   610 KHNLMTVEQNNGSSQKKLLAPDMFTESDDMFAAYFDSARLRAAGIGKDFKENPNLRDNWTDAEGY 674
            ||||: .::..|::.||..||||||||||||||.||.||||||||||||||||||||||||||||
Zfish   614 KHNLI-AQEKEGNNPKKPSAPDMFTESDDMFAADFDGARLRAAGIGKDFKENPNLRDNWTDAEGY 677

Human   675 YRVNIGEVLDKRYNVYGYTGQGVFSNVVRARDNARANQEVAVKIIRNNELMQKTGLKELEFLKKL 739
            |||||||:|||||:||||||||||||||||||.|||.||||||||||||||||||||||||||||
Zfish   678 YRVNIGEILDKRYDVYGYTGQGVFSNVVRARDTARAGQEVAVKIIRNNELMQKTGLKELEFLKKL 742

Human   740 NDADPDDKFHCLRLFRHFYHKQHLCLVFEPLSMNLREVLKKYGKDVGLHIKAVRSYSQQLFLALK 804
            |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
Zfish   743 NDADPDDKFHCLRLFRHFYHKQHLCLVFEPLSMNLREVLKKYGKDVGLHIKAVRSYSQQLFLALK 807

Human   805 LLKRCNILHADIKPDNILVNESKTILKLCDFGSASHVADNDITPYLVSRFYRAPEIIIGKSYDYG 869
            ||||||||||||||||||||||||||||||||||||||||:|||||||||||||||:|||.||||
Zfish   808 LLKRCNILHADIKPDNILVNESKTILKLCDFGSASHVADNEITPYLVSRFYRAPEIVIGKPYDYG 872

Human   870 IDMWSVGCTLYELYTGKILFPGKTNNHMLKLAMDLKGKMPNKMIRKGVFKDQHFDQNLNFMYIEV 934
            ||||||||||||||||||||||.:||||||||||:||||||||||||:||||||||||||:||||
Zfish   873 IDMWSVGCTLYELYTGKILFPGSSNNHMLKLAMDVKGKMPNKMIRKGLFKDQHFDQNLNFLYIEV 937

Human   935 DKVTEREKVTVMSTINPTKDLLADLIGCQRLPEDQRKKVHQLKDLLDQILMLDPAKRISINQALQ 999
            ||||||||||||||||||||||||::|.|||||||||||.|||||||..||||||||||||||||
Zfish   938 DKVTEREKVTVMSTINPTKDLLADMVGGQRLPEDQRKKVMQLKDLLDGTLMLDPAKRISINQALQ 1002

Human  1000 HAFIQEKI 1007
            |.||||||
Zfish  1003 HPFIQEKI 1010

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
PRPF4B	NP_003904.3	Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1..99		48/116 (41%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	140..533		192/413 (46%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	559..583		18/24 (75%)
		STKc_PRP4	686..1003	CDD:271037	298/316 (94%)
		S_TKc	694..1003	CDD:214567	291/308 (94%)
prpf4bb	NP_998614.1	STKc_PRP4	689..1006	CDD:271037	298/316 (94%)
prpf4bb	NP_998614.1	S_TKc	697..1006	CDD:214567	291/308 (94%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C194336380
Domainoid	1	1.000	668	1.000	Domainoid score	I1291
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	1270	1.000	Inparanoid score	I1421
NCBI	1	1.000	-	-
OMA	1	1.010	-	-		QHG39472
OrthoDB	1	1.010	-	-		D108923at7742
OrthoFinder	1	1.000	-	-		FOG0003592
OrthoInspector	1	1.000	-	-		otm28041
orthoMCL	1	0.900	-	-		OOG6_102293
Panther	1	1.100	-	-	LDO	PTHR24056
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R996
SonicParanoid	1	1.000	-	-		X2065
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
ZFIN	1	1.500	-	-
	16	16.440