Protein Alignment PRPF4B and Hipk

DIOPT Version :9

• Sequence 1: NP_003904.3
• Gene: PRPF4B / 8899
• HGNCID: 17346
• Length: 1007
• Species: Homo sapiens
• Sequence 2: NP_001369036.1
• Gene: Hipk / 38070
• FlyBaseID: FBgn0035142
• Length: 1409
• Species: Drosophila melanogaster
• Alignment Length: 530
• Identity: 147/530 - (27%)
• Similarity: 236/530 - (44%)
• Gaps: 66/530 - (12%)

Human   504 FKGSLSEGMKVEQESSSDDN--LEDFDVEEEDEEALIEQRRIQRQAIVQKYKYLAEDSNMSVPSE 566
            |...|..|:.|...|...|.  ....|.....|:   :|:::|:|   |:...|.:.:..:..|.
  Fly    25 FCSGLGAGLSVRATSFYGDQTVTATTDGTRHQEQ---QQQQLQQQ---QQQHILRQPATSASTSS 83

Human   567 PSSPQSSTRTRSPSPDDILERVAADVKEYERENVDTFEASVKAKHNLMTVEQNNGSSQKKLLAPD 631
            .::..:|.|.|....|      ...|..|...:....:....|.....:|....||..    .||
  Fly    84 VAAAATSKRKRQTDCD------CGCVDSYNSSHGPPVQQDSSAAAGAGSVGSKAGSGP----GPD 138

Human   632 MFTESDDMFAAYFDSARLRAAGIGKDFKENPNLRDNWTDAEGYYRVNIGEV---LDKRYNVYGYT 693
            .......:     .:|..:.|..|......|..:.:.:.|:|.|::...||   |...|.|..:.
  Fly   139 GIGPISSL-----KTAHTKVATSGGHANTQPPSKRSSSGADGDYQLVQHEVLYSLSAEYEVLEFL 198

Human   694 GQGVFSNVVRARDNARANQEVAVKIIRNNELMQKTGLKELEFLKKLNDADPDDKFHCLRLFRHFY 758
            |:|.|..||:..... .::.||:||::|:....:.|..|:..|.:|:..:.|: |:.:|.|..|.
  Fly   199 GRGTFGQVVKCWKRG-TSEIVAIKILKNHPSYARQGQIEVSILSRLSQENADE-FNFVRAFECFQ 261

Human   759 HKQHLCLVFEPLSMNLREVLKKYGKDVGLHIKAVRSYSQQLFLALKLLKRCNILHADIKPDNILV 823
            ||.|.|||||.|..||.:.||: .|...|.:|.:|...:|:..||..||:..::|||:||:||::
  Fly   262 HKNHTCLVFEMLEQNLYDFLKQ-NKFSPLPLKYIRPILEQVLTALLKLKQLGLIHADLKPENIML 325

Human   824 NE---SKTILKLCDFGSASHVADNDITPYLVSRFYRAPEIIIGKSYDYGIDMWSVGCTLYELYTG 885
            .:   ....:|:.||||||||:......||.||:|||||||:|..:...|||||:||.:.||:.|
  Fly   326 VDPVRQPYRVKVIDFGSASHVSKTVCNTYLQSRYYRAPEIILGLPFCEAIDMWSLGCVVAELFLG 390

Human   886 KILFPGKTNNHMLKLAMDLKGKMPNKMIRKGVFKDQHFDQNLNFMYIEVD--------KVTEREK 942
            ..|:||.:....::.....:|.....|:...       .:...|.|.:||        |.||..:
  Fly   391 WPLYPGSSEFDQIRYISQTQGLPTEHMLNSA-------SKTSKFFYRDVDSTYPFWRLKTTEEHE 448

Human   943 VTVMSTINPTKDLL-------------ADLIGCQRLPE--DQRKKVHQLKDLLDQILMLDPAKRI 992
            ....:.....:..:             .||.|.|.|.|  |:|:.:    |||.::|.:|..:|:
  Fly   449 AETNTKSKEARKYIFNCLDDIGQVNVPTDLEGGQLLAEKTDRREFI----DLLKRMLTIDQERRL 509

Human   993 SINQALQHAF 1002
            :..:||.|:|
  Fly   510 TPAEALNHSF 519

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
PRPF4B	NP_003904.3	Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	1..99
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	140..533		7/30 (23%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	559..583		4/23 (17%)
		STKc_PRP4	686..1003	CDD:271037	111/343 (32%)
		S_TKc	694..1003	CDD:214567	109/335 (33%)
Hipk	NP_001369036.1	STKc_HIPK	192..520	CDD:271113	111/342 (32%)
		PHA03378	<1080..1327	CDD:223065

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG0667
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	2	1.810