DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment PRPF4B and CG7028

DIOPT Version :9

Sequence 1:	NP_003904.3	Gene:	PRPF4B / 8899	HGNCID:	17346	Length:	1007	Species:	Homo sapiens
Sequence 2:	NP_001286884.1	Gene:	CG7028 / 38032	FlyBaseID:	FBgn0027587	Length:	912	Species:	Drosophila melanogaster

Alignment Length:	1026	Identity:	437/1026 - (42%)
Similarity:	576/1026 - (56%)	Gaps:	169/1026 - (16%)

- Green bases have known domain annotations that are detailed below.

Human    32 SEDQSQNKHSRHKKKKHKHRSKHKKHKHSS--EEDKDKKHKHKHKHKKHKRKEIIDASDKEGMSP 94
            |.|.|.|..:..::.|||...||||||.||  :.:|| :|.||.:.|..||......|..|..:|
  Fly     6 SYDSSNNSETEERRAKHKKAKKHKKHKKSSTGKTEKD-RHVHKKQKKAKKRPHRTSESTNESDAP 69

Human    95 AKRTKLDDLALLEDLEKQRALIKAELDNELMEGKVQSGMGLILQGYESGSEEEGEIHEKA-RNG- 157
             :..||                           |:....||        |.:..||.:|| |||
  Fly    70 -ENAKL---------------------------KLSQNCGL--------SSKFTEIMQKASRNGA 98

Human   158 -----------NRSSTRSSSTKGKLELVDNKITTKKRSKSRSKERTRHRSDKKKSKGGIEIVKEK 211
                       :.||.....||    .:.||:                          :.:::..
  Fly    99 DFRVGKPLLPTDPSSLVEEITK----TIQNKM--------------------------LPVLEVA 133

Human   212 TTRSKSKERKKSKSPSKRSKSQDQARKSKSPTLRRRSQEKIGKARS--PTDDKVKIEDKSKSKD- 273
            ::.|:|.....:.||...|..:|:....:....:...|.::|...|  ..:||..:...:.|:.
  Fly   134 SSSSESDVPADAASPIILSIIEDELNLEELMRQKALLQARLGAYMSDPEAEDKGDLLPHTHSQQL 198

Human   274 --RKKSPIINESRSRDRGKKSRSPVDLRGKSKDRRSRSKERKSKRSETDKEKKPIKSPSKDASSG 336
              ..|| ::....|..:.:.|:|...|      ..:.||....|:|.|....:.......|:|.|
  Fly   199 VVHTKS-VLKAVTSVPQPQPSKSAAPL------ATATSKHANIKKSTTHNSNESDVILLDDSSGG 256

Human   337 KENRSPSRRPGRSPKRRSLSP---KPRDKSRRSRSPLLNDRRSK-QSKSPSRTLSPGR------R 391
            :  |:||..|.:  :||..||   .||.:.||       ||||: :.:||.|..:..:      |
  Fly   257 Q--RTPSPTPEK--RRRHASPLPAAPRSRCRR-------DRRSRDRDRSPPRRRASDQQTQVRPR 310

Human   392 AKSRSLERKRREPERRRLSSPRTRPRDDILSRRERSKDASPINRWSPTRRRSRSPIRRRSRSPLR 456
            :::|::|..|:|..|.:....|...||    |..|..|..|    .||..|   |.|.|.|. :|
  Fly   311 SRNRNMEDLRQEINRDKQRERRDHSRD----RDRRGLDRPP----PPTDMR---PGRARERD-VR 363

Human   457 RSRSPRRRSRSPRRRDRGRRSRSRLRRRSRSRGGRRRRSRSKV---KEDKFKGSLSEGM-KVEQE 517
            .||..|..|||....|   |.|.|.|::.|.|||.|..:||..   ..|::|||||||. |:::|
  Fly   364 PSRMQRSHSRSKFESD---RRRERERQKDRDRGGGRVGARSGTDNGDRDRYKGSLSEGQNKLDKE 425

Human   518 SSSDDNLEDFDV-EEEDEEALIEQRRIQRQAIVQK----YKYLAEDSNMSVPSEPSSPQSSTRTR 577
            ||.::...:.|: ||:|||.:||.||.:|:.:::|    .:..|..:::|..|..:|..||.|.|
  Fly   426 SSDEEVNVNIDILEEDDEERIIELRRKKREELLKKLGTGQESPAPHNSVSYESRSTSQGSSQRER 490

Human   578 --------SPSPDDILERVAADVKEYERENVDTFEASVKAKHNLMTVEQNNGSSQKKLLAPDMFT 634
                    .|.|:.::..:..|     ||::|.            :..|...|:::|....|||.
  Fly   491 PLRTPSPTMPCPNPLISEIPKD-----REDMDN------------STSQKTCSAKEKRNEWDMFA 538

Human   635 ESDDMFAAYFDSARLRAAGI---GKDFKENPNLRDNWTDAEGYYRVNIGEVLDKRYNVYGYTGQG 696
            :.|  ..:.||.:|..:...   .|...|||.|.|||.||||||||.||||||.||.|.||||||
  Fly   539 DQD--VDSNFDVSRKISPNTIVQNKHQHENPALTDNWDDAEGYYRVRIGEVLDNRYLVNGYTGQG 601

Human   697 VFSNVVRARDNARANQEVAVKIIRNNELMQKTGLKELEFLKKLNDADPDDKFHCLRLFRHFYHKQ 761
            |||||||.||.||....||:|||||||:|.||||:|||.|||||||||:|:||||||:|||:|||
  Fly   602 VFSNVVRGRDQARGQANVAIKIIRNNEIMHKTGLRELEILKKLNDADPEDRFHCLRLYRHFFHKQ 666

Human   762 HLCLVFEPLSMNLREVLKKYGKDVGLHIKAVRSYSQQLFLALKLLKRCNILHADIKPDNILVNES 826
            |||:|||||:||||||||||||:|||||||||||:|||||||||||:..|||||||||||||||:
  Fly   667 HLCMVFEPLAMNLREVLKKYGKNVGLHIKAVRSYTQQLFLALKLLKKTGILHADIKPDNILVNEN 731

Human   827 KTILKLCDFGSASHVADNDITPYLVSRFYRAPEIIIGKSYDYGIDMWSVGCTLYELYTGKILFPG 891
            ..|||||||||||.::||:|||||||||||:||||:|..||||||.||.|||:||||||||||.|
  Fly   732 NLILKLCDFGSASAISDNEITPYLVSRFYRSPEIILGIPYDYGIDTWSAGCTIYELYTGKILFSG 796

Human   892 KTNNHMLKLAMDLKGKMPNKMIRKGVFKDQHFDQNLNFMYIEVDKVTEREKVTVMSTINPTKDLL 956
            |:||.|||..||:|||:||::||||.|::|||||:.||:|.|:||:|||||:.||..:.|::.|.
  Fly   797 KSNNQMLKFFMDVKGKIPNRIIRKGQFREQHFDQSCNFLYHEIDKLTEREKIVVMPVVKPSRSLQ 861

Human   957 ADLIGCQRLPEDQRKKVHQLKDLLDQILMLDPAKRISINQALQHAFIQEKI 1007
            .:||..|.||:||.:||.||||||:.:..||||||||:||||.|.|||||:
  Fly   862 QELIADQNLPDDQHRKVTQLKDLLENMFALDPAKRISLNQALVHPFIQEKM 912

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
PRPF4B	NP_003904.3	Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1..99		26/68 (38%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	140..533		113/425 (27%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	559..583		9/31 (29%)
		STKc_PRP4	686..1003	CDD:271037	233/316 (74%)
		S_TKc	694..1003	CDD:214567	227/308 (74%)
CG7028	NP_001286884.1	STKc_PRP4	591..908	CDD:271037	233/316 (74%)
CG7028	NP_001286884.1	S_TKc	599..908	CDD:214567	227/308 (74%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C165154979
Domainoid	1	1.000	487	1.000	Domainoid score	I394
eggNOG	1	0.900	-	-		E1_KOG0667
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	649	1.000	Inparanoid score	I794
Isobase	1	0.950	-	0	Normalized mean entropy	S2103
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0003592
OrthoInspector	1	1.000	-	-		oto89816
orthoMCL	1	0.900	-	-		OOG6_102293
Panther	1	1.100	-	-	LDO	PTHR24056
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R996
SonicParanoid	1	1.000	-	-		X2065
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	13	12.770