Protein Alignment PRPF4B and mnb

DIOPT Version :9

• Sequence 1: NP_003904.3
• Gene: PRPF4B / 8899
• HGNCID: 17346
• Length: 1007
• Species: Homo sapiens
• Sequence 2: NP_728107.2
• Gene: mnb / 32771
• FlyBaseID: FBgn0259168
• Length: 1047
• Species: Drosophila melanogaster
• Alignment Length: 560
• Identity: 161/560 - (28%)
• Similarity: 249/560 - (44%)
• Gaps: 88/560 - (15%)

Human   471 RDRGRRSRSRLR-RRSRSRGGRRRRSRSKVKEDKFKGSLSEGMKVEQESSSDDNLEDFDVEEEDE 534
            |||.|...:.|. :.|.|...|.:..|:........||....:...|.|.|....
  Fly   127 RDRDRVDGNVLMVQGSSSSSSRMKAERALYYTMSAYGSSGGSVDAAQGSGSGGGR---------- 181

Human   535 EALIEQRRIQRQAIVQKYKYLAED---SNMSVPSEPSSPQSSTRTRSPS---PDDILERVAADVK 593
                     ||.|.:......|||   ::..|....|||.||:..|:..   |:...|..:..::
  Fly   182 ---------QRHAPLYGRFVDAEDLPATHRDVMHHHSSPSSSSEVRAMQARIPNHFREPASGPLR 237

Human   594 EYERENVDTFEASVKAKH-NLMTVEQNNGSSQKKLLAPDMFTESDDMFAAYFDSARLRAAGIGKD 657
            :...:.:.|:      || |.:...:....:|:        |:.||      ||:         :
  Fly   238 KLSVDLIKTY------KHINEVYYAKKKRRAQQ--------TQGDD------DSS---------N 273

Human   658 FKENPNLRDNWTDAEGYYRVNIGEVLDKRYNVYGYTGQGVFSNVVRARDNARANQEVAVKIIRNN 722
            .||.....|.:.|....|.:..||....||.:....|:|.|..||:|.|: .....||:|||:|.
  Fly   274 KKERKLYNDGYDDDNHDYIIKNGEKFLDRYEIDSLIGKGSFGQVVKAYDH-EEQCHVAIKIIKNK 337

Human   723 ELMQKTGLKELEFLKKLNDADPDDKFHCLRLFRHFYHKQHLCLVFEPLSMNLREVLKKYGKDVGL 787
            :........|::.|:.:|.||.::|::.::|.|||..:.|||||||.||.||.::|:..... |:
  Fly   338 KPFLNQAQIEVKLLEMMNRADAENKYYIVKLKRHFMWRNHLCLVFELLSYNLYDLLRNTNFR-GV 401

Human   788 HIKAVRSYSQQLFLALKLLK--RCNILHADIKPDNILV-NESKTILKLCDFGSASHVADNDITPY 849
            .:...|.::|||..||..|.  ..||:|.|:||:|||: |..::.:|:.||||:..:... |..|
  Fly   402 SLNLTRKFAQQLCTALLFLSTPELNIIHCDLKPENILLCNPKRSAIKIVDFGSSCQLGQR-IYHY 465

Human   850 LVSRFYRAPEIIIGKSYDYGIDMWSVGCTLYELYTGKILFPGKTNNHMLKLAMDLKGKMPNKMIR 914
            :.|||||:||:::|..||..|||||:||.|.|::||:.||.|......:...:::.| ||.|.:.
  Fly   466 IQSRFYRSPEVLLGIQYDLAIDMWSLGCILVEMHTGEPLFSGCNEVDQMNKIVEVLG-MPPKYLL 529

Human   915 KGVFKDQHFDQNLNFMYIEVDKVTEREKVTVMSTIN------PTKDLLADLIGCQ-------RLP 966
            ....|.:.|          .||:.......:....|      |....|.|::|.:       ||.
  Fly   530 DQAHKTRKF----------FDKIVADGSYVLKKNQNGRKYKPPGSRKLHDILGVETGGPGGRRLD 584

Human   967 EDQRKKVHQL--KDLLDQILMLDPAKRISINQALQHAFIQ 1004
            |........|  |||:.::|..||..|::...||||.|.:
  Fly   585 EPGHSVSDYLKFKDLILRMLDFDPKTRVTPYYALQHNFFK 624

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
PRPF4B	NP_003904.3	Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	1..99
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	140..533		14/62 (23%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	559..583		8/26 (31%)
		STKc_PRP4	686..1003	CDD:271037	114/334 (34%)
		S_TKc	694..1003	CDD:214567	112/326 (34%)
mnb	NP_728107.2	PKc_DYRK1	289..628	CDD:271128	118/350 (34%)
		S_TKc	303..623	CDD:214567	113/333 (34%)

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG0667
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	2	1.810