Protein Alignment MTMR2 and YMR1

DIOPT Version :10

• Sequence 1: NP_057240.3
• Gene: MTMR2 / 8898
• HGNCID: 7450
• Length: 643
• Species: Homo sapiens
• Sequence 2: NP_012644.1
• Gene: YMR1 / 853574
• SGDID: S000003871
• Length: 688
• Species: Saccharomyces cerevisiae
• Alignment Length: 661
• Identity: 195/661 - (29%)
• Similarity: 310/661 - (46%)
• Gaps: 152/661 - (22%)

Human   100 AVRGTLTVTNYRLYFKS----------------MERDPPFVLDASLGVINRVEKIGGASSRGENS 148
            |.:|||.:|.:.|.|:|                :.::|...|.:.|...|::: :.|..|:....
Yeast    20 ATQGTLHLTTHHLIFESPQLSTEFWFPYPLIYGVHKNPGSTLLSKLTSTNQIQ-LEGTDSQNYKL 83

Human   149 Y---------GLETVCKD--IRNLRFAHKPEGRTRRSIFENLMKYAFPVSNNLPLFAFEY----- 197
            |         .::.:.||  :.:|.|......:.|: ::::::.... :||...|:||.|
Yeast    84 YQGKDLWSFVNIKVIGKDYAVFSLDFGGDLHLQARK-VYDSILNLTV-LSNITQLYAFIYISNNL 146

Human   198 -KEVFPENGWKLYDPLLEYRRQGIPNES----WRITKINERYELCDTYPALLVVPANIPDEELKR 257
             :::...:.|.:|||:.|:||||:.::.    ||::.:||.||.|.|||:.|.||.:..|..||.
Yeast   147 ERKLPSPDSWDIYDPIKEFRRQGLDSKDETCPWRLSTVNEHYEFCPTYPSKLFVPRSTSDILLKH 211

Human   258 VASFRSRGRIPVLSWIHPESQATITRCSQPMVGVSGKRSKEDEKYL----QAIMDSNAQSHKIFI 318
            .:.|||:.|||||::.|..:...|.|.|||:.|:..:||.:|||.:    .:..:.:.:..|..|
Yeast   212 ASKFRSQKRIPVLTYHHKATDCNILRSSQPLPGLINQRSIQDEKLVWESFNSFCNKDIRRTKHVI 276

Human   319 FDARPSVNAVANKAKGGGYESEDAYQ-----------------NAELVFLDIHNIHVMRESLRKL 366
            .||||..||:|..|.|||.|:.|.|.                 ....:||.|.|||::..:...:
Yeast   277 VDARPRTNALAQMALGGGTENMDNYNFFLADNNMGVDKSLKLPTVTRLFLGIDNIHIVSNTAAYM 341

Human   367 KEIVYPNIE-----ETHWLSNLESTHWLEHIKLILAGALRIADKVESGKTSVVVHCSDGWDRTAQ 426
            .|::....:     |.:.:.:.:.::||:...|||.....:...:....::|:||||||||||:|
Yeast   342 TEVICQGGDLNLPLEQNLIRSQKFSNWLKLNTLILKSVDMLLKSIIFNHSNVLVHCSDGWDRTSQ 406

Human   427 LTSLAMLMLDGYYRTIRGFEVLVEKEWLSFGHRFQLRVGH----------------------GD- 468
            :.||..:.||.:|||..||.:||||:|.||||||..|.||                      ||
Yeast   407 VVSLLEICLDPFYRTFEGFMILVEKDWCSFGHRFLERSGHLNSDIRFHDNTMHSNFNDVDTNGDD 471

Human   469 --------KNHADADR--------------------------------SPVFLQFIDCVWQMTRQ 493
                    .::|:.|.                                ||||.||:|||:|:..|
Yeast   472 LDIGVNTQDDYAEDDEGGEDETNLINLSRISKKFNENFKLNKKSLKFVSPVFQQFLDCVYQLLTQ 536

Human   494 FPTAFEFNEYFLITILDHLYSCLFGTFLCNSEQQRGKENLPKRTVSLWSYINSQLEDFTNPLY-- 556
            .|..|||||.||..::.|||||.:||||.|||:::.::|||.:|.|:|.|..|:.:.|.||.:
Yeast   537 NPDLFEFNERFLRRLVYHLYSCQYGTFLSNSEKEKFQQNLPNKTKSVWDYFRSRRKQFINPNFIQ 601

Human   557 ---GSYSNH---------VLYPVASMRHLELWVGYYIRWNPRMKPQEPIHNRYKELLAKRAELQK 609
               ...:.|         |.:....::.::.|...|.|.:..|.         .||..||..:..
Yeast   602 RKRSGMNEHDQNLEEEEKVEWISPDLKKVQWWWQLYGRKDSEMN---------DELRHKRDSVPI 657

Human   610 KVEELQREISN 620
            .|::..:|.||
Yeast   658 SVDKKSKEHSN 668

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
MTMR2	NP_057240.3	Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	1..56
		PH-like	73..187	CDD:473070	20/113 (18%)
		Myotub-related	202..528	CDD:461958	144/418 (34%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	615..643		3/6 (50%)
YMR1	NP_012644.1	PH-like	1..>44	CDD:473070	8/23 (35%)
		Myotub-related	152..570	CDD:461958	144/417 (35%)