Protein Alignment MTMR2 and Sbf

DIOPT Version :10

• Sequence 1: NP_057240.3
• Gene: MTMR2 / 8898
• HGNCID: 7450
• Length: 643
• Species: Homo sapiens
• Sequence 2: NP_477401.2
• Gene: Sbf / 41427
• FlyBaseID: FBgn0025802
• Length: 1993
• Species: Drosophila melanogaster
• Alignment Length: 814
• Identity: 200/814 - (24%)
• Similarity: 285/814 - (35%)
• Gaps: 305/814 - (37%)

Human    72 EMEEPPLLPGENI----------KDMAKDVTY-ICPFTGAVRGTLTVTNYRLYFKSMERDPPFVL 125
            :::.|.|||||::          .|..:|.|. :.|..||    |.:||||:.||....||.|..
  Fly   923 KIQTPCLLPGEDLVTDHLRCFLMPDGREDETQCLIPAEGA----LFLTNYRVIFKGSPCDPLFCE 983

Human   126 DASLGVINRVEKIGGASSRGENSYGLETVCKDIRNLRFAH----KPEGRTRRSIFENLMKYAFP- 185
            .    ||.|...|  ||...|         |.|..|..||    ..||...||....|:|.||.
  Fly   984 Q----VIVRTFPI--ASLLKE---------KKISVLYLAHLDQTLTEGLQLRSSSFQLIKVAFDP 1033

Human   186 --------------VSNNLPLFAFEY------------------KEVF---------------PE 203
                          .....|...|||                  ||.:               .:
  Fly  1034 EVTPEQIESFRKILSKARHPFDEFEYFAFQSYGTMLQGVAPLKTKEKYSTLKGFAKKTLLRGAKK 1098

Human   204 NGWKL-----------YD-----------------------------PLL--------------- 213
            .|:|.           ||                             |.|
  Fly  1099 AGFKQKQQTKRKLVSDYDYGSADAQETQSIDDELEDGDEFETQNNAMPRLLTTKDVERMRERSYV 1163

Human   214 -EYRRQGIPNES---WRITKINERYELCDTYPALLVVPANIPDEELKRVASFRSRGRIPVLSWIH 274
             :::|.|...||   :||:..|..|..|.:|||::|.|....|..:..:.......|||:.:|.|
  Fly  1164 QDWKRLGFDAESQRGFRISNANTSYATCRSYPAIIVAPVQCSDAAIMHLGRCFKGQRIPLPTWRH 1228

Human   275 PESQATITRCSQP----MVGV----SGKRSK---------EDEKYLQAIMD-------------- 308
            ... |.:.|..||    ::|:    :|..:.         |.:||..|:::
  Fly  1229 ANG-ALLIRGGQPNSKSVIGMLKNTTGSTTNAHHDVTHYPEQDKYFLALINTMPKLTPLALNQYS 1292

Human   309 ------SNAQSHKIFIFDARPSVNAVA------------NKAKGGGY------------------ 337
                  |:...|. ...|.:|....::            ||:..||.
  Fly  1293 GMNLSMSSLMGHS-SSDDRQPLTPELSRKHKNNLDISDGNKSSQGGKGGTMKGNPKNSLAHPFRK 1356

Human   338 -------ESEDAYQN------AELVFLDIHNIHVMRESLRKLKEIVYP--NIEET---HWLSNLE 384
                   |...|..|      |:.:.:|..:|...|.:.:||.....|  |..|.   .:...:|
  Fly  1357 MRLYALGEKSQAKSNMNVDFCADFIPVDYPDIRQSRPAFKKLIRACMPSHNTNEADGQSFAKMVE 1421

Human   385 STHWLEHIKLI--LAGALRIADKVESGKTSVVVHCSDGWDRTAQLTSLAMLMLDGYYRTIRGFEV 447
            .:.||:.|..:  |:||  :.|.::..::||::...||.|.||||:|:|.|.||.|||::.||.|
  Fly  1422 QSDWLQQISSLMQLSGA--VVDLIDLQESSVMLSLEDGSDVTAQLSSIAQLCLDPYYRSLDGFRV 1484

Human   448 LVEKEWLSFGHRF----QLRVGHGDKNHADADRSPVFLQFIDCVWQMTRQFPTAFEFNEYFLITI 508
            |||||||:|||||    .|:..|.:.|.|.|   |.||||:|.|.|:.||||.|||||:::|..:
  Fly  1485 LVEKEWLAFGHRFAHRSNLKPSHANTNIAFA---PTFLQFLDVVHQLQRQFPMAFEFNDFYLRFL 1546

Human   509 LDHLYSCLFGTFLCNSEQQRGKENL---------------------------------------- 533
            ..|..||.|.|||.:.|.:|....:
  Fly  1547 AYHSVSCRFRTFLFDCELERSDSGIAAMEDKRGSLNAKHMFGAGGMATNGSDDECSVYPLDIRSQ 1611

Human   534 ----PKRTV--SLWSYINSQLED---FTNPLYGSYSNHVLYPVASMRHLELWVGYYIRWNPRMKP 589
                |...:  |::.||..|...   |.|.||....:..|.|..::..|:||. ||.
  Fly  1612 RAPAPLNRIGHSIFDYIERQHNKTPIFYNFLYSGDKSVTLRPQNNVAALDLWC-YYT-------- 1667

Human   590 QEPIHNRYKELLAKRAELQKKVEELQREISNRST 623
                    .|.||:.|....:|..:..||....|
  Fly  1668 --------NEELAQGAPYDLEVTTVDDEIDLSET 1693

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
MTMR2	NP_057240.3	Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	1..56
		PH-like	73..187	CDD:473070	42/143 (29%)
		Myotub-related	202..528	CDD:461958	127/475 (27%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	615..643		3/9 (33%)
Sbf	NP_477401.2	uDENN	1..91	CDD:214824
		DENN	142..325	CDD:460461
		dDENN	384..452	CDD:129037
		SBF2	584..807	CDD:463536
		PH-GRAM_MTMR5_MTMR13	933..1047	CDD:275396	37/132 (28%)
		PTP-MTMR5-like	1179..1531	CDD:350382	99/358 (28%)
		C1_Sbf-like	1790..1840	CDD:410377
		PH_Sbf1_hMTMR5	1888..1993	CDD:269941