Protein Alignment MTMR2 and CG3632

DIOPT Version :10

• Sequence 1: NP_057240.3
• Gene: MTMR2 / 8898
• HGNCID: 7450
• Length: 643
• Species: Homo sapiens
• Sequence 2: NP_001096996.1
• Gene: CG3632 / 32589
• FlyBaseID: FBgn0030735
• Length: 1250
• Species: Drosophila melanogaster
• Alignment Length: 735
• Identity: 221/735 - (30%)
• Similarity: 336/735 - (45%)
• Gaps: 168/735 - (22%)

Human    37 VHTKS-ASVVSSDSISTSADNFSPDLRVLRESNKL-AEMEEPPLLPGENIKDMAKDVTYICPFTG 99
            :||.| .|...|.....:|::: |..::.:|.::| ...:|   |.||:||.:.:
  Fly     7 IHTMSDGSPPPSICFIRAAESY-PKSQMEKEDSQLFVPFQE---LAGESIKYLGR---------- 57

Human   100 AVRGTLTVTNYRLYFKSMERDPPFVLDASLGVINRVEKIGGASSRGENSYGLETVCKDIRNLR-- 162
            ...|.|.::|||::..  ::...:.....||:|..|:.        .:.:.|...|||...:|
  Fly    58 TDDGILALSNYRIFLS--KQSTGYETYVPLGLIESVQV--------RDLFQLIVNCKDASTVRCS 112

Human   163 --FAHKPEGRTRR-----SIFENL-MKYAFP---------------------------------- 185
              .|.:.....||     .:.|:| ..:|||
  Fly   113 FPSAEQCSDWQRRIHLMIGVPESLETLFAFPFYSWTCDVLGSGNGSGIVSAQANGNGLIAKDRCL 177

Human   186 --------------VSNNLPLFAFE----------YKEVFPENGWKLYDPLLEYRRQGIPNESWR 226
                          .||.||..|.|          .:.|..|:.:|.....|.:..:|    |||
  Fly   178 TLHNGLAKPTANVTASNPLPDPASETISAAMSNRLQRSVRYESDFKNEVARLGFDLKG----SWR 238

Human   227 ITKINERYELCDTYPALLVVPANIPDEELKRVASFRSRGRIPVLSWIHPESQATITRCSQPMVGV 291
            |:..|..::||.:||..|:||..|.||.|..||:||...|:|.:.|.|.:|.|.:.|||||.||.
  Fly   239 ISTANADFKLCPSYPPKLLVPCCITDEMLHNVANFRGSRRLPAVVWRHQKSGAILARCSQPEVGW 303

Human   292 SGKRSKEDEKYLQAIMD----------------------------SNAQS--------------- 313
            .|.|:..||:.|:|:.|                            :|.||
  Fly   304 LGWRNTRDEQLLKALADACAFDRGEHARHSTCANAKAQPTKGSKETNGQSGLSGKSSPSLDDSSH 368

Human   314 --------HKIFIFDARPSVNAVANKAKGGGYESEDAYQNAELVFLDIHNIHVMRESLRKLKEIV 370
                    .||.|.|||...:||.|:|:|||.|..:.|..||:.|:::.|||.:|:|...::::.
  Fly   369 EELTLDEIKKILIVDARSYTSAVTNRARGGGCECIEYYPCAEIEFMNLGNIHAIRKSFHAVRQLC 433

Human   371 YPNIEETHWLSNLESTHWLEHIKLILAGALRIADKVESGKTSVVVHCSDGWDRTAQLTSLAMLML 435
            ..:.::.:|...||.|.|::|:..:|...:.:...:|.....|:||||||||||.|:.:.|.|.|
  Fly   434 ASSPDDPNWYGQLEKTMWMQHLSGLLGATMTVVHTIEKNGRPVLVHCSDGWDRTPQIVATAQLCL 498

Human   436 DGYYRTIRGFEVLVEKEWLSFGHRFQLRVGHGDKNHADADRSPVFLQFIDCVWQMTRQFPTAFEF 500
            |.||||:.||.||||:|||:|||:|..|.|:|..:....:|.|||||::|.|.|:.||:|.:|||
  Fly   499 DPYYRTVEGFRVLVEREWLNFGHKFADRSGNGPNSDEVNERCPVFLQWLDLVHQIHRQYPCSFEF 563

Human   501 NEYFLITILDHLYSCLFGTFLCNSEQQRGKENLPKRTVSLWSYINSQLEDFTNPLYGSYSNHVLY 565
            :..:||.:..|..|||||||||||.::|.:.::..||.|:|.::...:  :.||||...:..||:
  Fly   564 SISYLIKLAQHSLSCLFGTFLCNSLRERIENSVFDRTFSVWPFLAETM--YRNPLYKHETEKVLW 626

Human   566 PVASMRHLELWVGYYI----RWNPRMKP-----QEPIHNRYKELLAKRAELQKKVEELQREISNR 621
            |..|:|.|..|...|:    ..|....|     ::..||   .|:||    .:..|:|......:
  Fly   627 PAHSVRFLYFWSDVYLGSLGNKNGTDLPLLSNERQSGHN---GLMAK----TRSSEDLTTNELGQ 684

Human   622 STSSSERASSPAQCVTPVQT 641
            || .|.|:|.|...|..:.|
  Fly   685 ST-ISRRSSDPNLTVESIVT 703

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
MTMR2	NP_057240.3	Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	1..56		6/19 (32%)
		PH-like	73..187	CDD:473070	28/171 (16%)
		Myotub-related	202..528	CDD:461958	143/376 (38%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	615..643		8/27 (30%)
CG3632	NP_001096996.1	PH-like	35..147	CDD:473070	30/134 (22%)
		Myotub-related	221..591	CDD:461958	142/373 (38%)
		FYVE_MTMR4	1162..1221	CDD:277272