DRSC/TRiP Functional Genomics Resources

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Protein Alignment MTMR2 and ymr1

DIOPT Version :10

Sequence 1:NP_057240.3 Gene:MTMR2 / 8898 HGNCID:7450 Length:643 Species:Homo sapiens
Sequence 2:NP_593789.1 Gene:ymr1 / 2542522 PomBaseID:SPAC19A8.03 Length:559 Species:Schizosaccharomyces pombe


Alignment Length:576 Identity:211/576 - (36%)
Similarity:294/576 - (51%) Gaps:89/576 - (15%)


- Green bases have known domain annotations that are detailed below.


Human    82 ENIKDMAK--DVTYICPFTGAVRGTLTVTNYRLYFKSMERDPPFVLDASLGVINRVEKIGGASSR 144
            |||| :||  :|.::.. ...:.|||.:|.|...|...|....  :..:..:||.|:...     
pombe     2 ENIK-VAKVGNVKFVNK-GNELNGTLHLTAYHSIFSISENGKE--IWTAYSMINNVKLCS----- 57

Human   145 GENSYGLETVCKDIRNL--RFAHKPEGRTRRSIFENLMKYAFPVSNNLPLFAFEY-----KEVFP 202
            .|.|:.:...|:|....  ||....:.   ..:::.|.:.....|.|: |:||.|     :|..|
pombe    58 NEKSFCIRIQCRDFMFFCWRFQSTEDA---MDVYDTLQELMSINSINM-LYAFYYMPSGDEEKLP 118

Human   203 ENGWKLYDPLLEYRRQGIPNE--------SWRITKINERYELCDTYPALLVVPANIPDEELKRVA 259
             :.||.:....||||.|:.:.        :||||||||.|..|.:||..|.|||:|.|..:....
pombe   119 -SSWKSFLLENEYRRMGVGDSTQADGAGGNWRITKINENYSECHSYPQALAVPASISDSVIYYGC 182

Human   260 SFRSRGRIPVLSWIHPESQATITRCSQPMVGVSGKRSKEDEKYLQAIM-DSNAQSHKIFIFDARP 323
            .:||:.|.|.|:::|..| .:|||.|||:||:...||.:|||.::||. .|.....:..|.||||
pombe   183 KYRSKNRFPTLTYLHKNS-FSITRASQPLVGIRQNRSAQDEKLVEAIFATSIIPGKENLIVDARP 246

Human   324 SVNAVANKAKGGGYESEDAYQNAELVFLDIHNIHVMRESLRKLKEIVY--------PNIEETHWL 380
            |.||:||.|.|.|.|:.|.|:.|:.::|.|.||||||:||.|:...:.        |.||    |
pombe   247 STNAMANIAVGAGSENMDHYRFAKKIYLGIDNIHVMRDSLNKIVNALKNTDISAAPPLIE----L 307

Human   381 SNLESTHWLEHIKLILAGALRIADKVESGKTSVVVHCSDGWDRTAQLTSLAMLMLDGYYRTIRGF 445
            .|..|  ||:|:..||.||:.|...|......|:||||||||||:||.:|..|.||.|||||.||
pombe   308 LNRSS--WLKHLANILQGAVLIVKTVHFRHAHVLVHCSDGWDRTSQLCALPQLCLDPYYRTIEGF 370

Human   446 EVLVEKEWLSFGHRFQLRVGH--GDK-------------------------------------NH 471
            ..||||:||||||||..|..|  |.:                                     :|
pombe   371 FALVEKDWLSFGHRFAERCCHLPGKRIFTIDSSYSEEPPQSSPSSTLQYTFSTVRSALSGFSIDH 435

Human   472 ADADRSPVFLQFIDCVWQMTRQFPTAFEFNEYFLITILDHLYSCLFGTFLCNSEQQRGKENLPKR 536
            ::...||||.||:|||||:..|||..|||||.||..:|.|||||.:|:||.|||::|.:.::...
pombe   436 SEKMMSPVFHQFLDCVWQIMDQFPNCFEFNERFLRRLLYHLYSCQYGSFLYNSERERAQASVSTH 500

Human   537 TVSLWSYINSQLEDFTNPLYGSYSNHVLYPVASMRHLELWVGYYIRWNPRMKPQEP 592
            |..:|.|..|:.::|.||.|..|.:.::...:|:|   .|...:.:.:..|....|
pombe   501 TRCIWDYFLSRKDEFKNPNYVPYDDVIMPDPSSLR---WWSASFAQPDENMNIPSP 553

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
MTMR2NP_057240.3 Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 1..56
PH-like 73..187 CDD:473070 24/108 (22%)
Myotub-related 202..528 CDD:461958 165/381 (43%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 615..643
ymr1NP_593789.1 PH-like 4..94 CDD:473070 22/101 (22%)
Myotub-related 120..492 CDD:461958 164/378 (43%)
Blue background indicates that the domain is not in the aligned region.

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