Protein Alignment MTMR2 and mtm-1

DIOPT Version :10

• Sequence 1: NP_057240.3
• Gene: MTMR2 / 8898
• HGNCID: 7450
• Length: 643
• Species: Homo sapiens
• Sequence 2: NP_491531.2
• Gene: mtm-1 / 172148
• WormBaseID: WBGene00003475
• Length: 588
• Species: Caenorhabditis elegans
• Alignment Length: 588
• Identity: 259/588 - (44%)
• Similarity: 368/588 - (62%)
• Gaps: 36/588 - (6%)

Human    56 NFSPDLRVLRESNKLAEMEEPPLLPGENIKDMAKDVTYICPFTGAVRGTLTVTNYRLYF------ 114
            |.|.::.....|:.:.|..:..||..|::....|:|||..|. |...|.:.:|.||:.|
 Worm     6 NNSGEVGEFASSSMIQESIDLKLLAAESLIWTEKNVTYFGPL-GKFPGKIVITRYRMVFLVGDGG 69

Human   115 KSMERDPPFVLDASLGVINRVEKIG----GASSRGENSYGLETVCKDIRNLRFAHKPEGRTRRSI 175
            |..|:   :.||..||.::|:||:|    ..:.||:::||....|||.|..||...|....|:::
 Worm    70 KMYEQ---WKLDIPLGQVSRIEKVGRKTTSVAKRGDDNYGFTIYCKDYRVYRFTCNPASSDRKNV 131

Human   176 FENLMKYAFPVSNNLPLFAFEYKEVFP---ENGWKLYDPLLEYRRQGIPNES-WRITKINERYEL 236
            .::|.:||||:|:|||:||..:....|   ::|||:|....||.|.||||.. |:...||:.|:.
 Worm   132 CDSLNRYAFPLSHNLPMFASVHAAETPRLMKDGWKIYSAEKEYERLGIPNSRLWKEVDINKDYKF 196

Human   237 CDTYPALLVVPANIPDEE----LKRVASFRSRGRIPVLSWIHPESQATITRCSQPMVGVSGKRSK 297
            .:|||...|:| .:..||    :|::..|||:.||||||||:..:.|:|:||||||.|:|||||.
 Worm   197 SETYPRTFVIP-TVSWEEGKPFVKKLGEFRSKERIPVLSWINQTTLASISRCSQPMTGISGKRSA 260

Human   298 EDEKYLQAIMDSNAQSHKIFIFDARPSVNAVANKAKGGGYESEDAYQNAELVFLDIHNIHVMRES 362
            |||::|..||::||...::.|.||||:|||..||||||||  |:.|.||.|.||:||||||:|:|
 Worm   261 EDERHLTNIMNANANCRELLILDARPAVNAKLNKAKGGGY--EENYVNAPLTFLNIHNIHVVRDS 323

Human   363 LRKLKEIVYPNIEETHWLSNLESTHWLEHIKLILAGALRIADKVESGKTSVVVHCSDGWDRTAQL 427
            |::|...:.|.::|..:...|:.:.||.|::.||.||::....|::.|.||::||||||||||||
 Worm   324 LKRLLAALIPRVDEKGYYKALDESKWLNHVQSILEGAVKAVFNVDTEKQSVLIHCSDGWDRTAQL 388

Human   428 TSLAMLMLDGYYRTIRGFEVLVEKEWLSFGHRFQLRVGHGDKNHADADRSPVFLQFIDCVWQMTR 492
            |||||:.||.|||||.||.||:||||.||||:|..|:||||.|::|.:|||||:||.||:||:.|
 Worm   389 TSLAMIQLDSYYRTIEGFIVLIEKEWCSFGHKFGERIGHGDDNYSDGERSPVFVQFCDCLWQIMR 453

Human   493 QFPTAFEFNEYFLITILDHLYSCLFGTFLCNSEQQRGKE-NLPKRTVSLWSYINSQLEDFTNPLY 556
            |||.||||.:..||.:||.||:|.:||||.|||:.|.|: ...:.|:|.|||:....:.|.||::
 Worm   454 QFPWAFEFTQELLICMLDELYACRYGTFLYNSEKIRLKDKKCDETTISFWSYVLENKKKFRNPMF 518

Human   557 -GSYSNHVLYPVASMRHLELWVGYYIRWNPRM---------KPQEPIHNRYKELLAKRAELQKKV 611
             ...||.|:....|:..|.:|:.||.|.||.:         :|.....:..|:||.:...|....
 Worm   519 KHGKSNKVINVNPSLCGLHVWIDYYARSNPYVVTPNHEDVQQPGAQFVDEKKQLLDEIMALDDAA 583

Human   612 EEL 614
            ::|
 Worm   584 QKL 586

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
MTMR2	NP_057240.3	Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	1..56		259/588 (44%)
		PH-like	73..187	CDD:473070	41/123 (33%)
		Myotub-related	202..528	CDD:461958	181/333 (54%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	615..643		259/588 (44%)
mtm-1	NP_491531.2	PH-GRAM_MTM-like	36..141	CDD:275407	36/108 (33%)
		Myotub-related	163..489	CDD:461958	180/328 (55%)