DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment SLC5A6 and CG2187

DIOPT Version :9

Sequence 1:	NP_066918.2	Gene:	SLC5A6 / 8884	HGNCID:	11041	Length:	635	Species:	Homo sapiens
Sequence 2:	NP_001189331.1	Gene:	CG2187 / 43743	FlyBaseID:	FBgn0017448	Length:	623	Species:	Drosophila melanogaster

Alignment Length:	606	Identity:	194/606 - (32%)
Similarity:	310/606 - (51%)	Gaps:	48/606 - (7%)

- Green bases have known domain annotations that are detailed below.

Human     5 VSTSAPLSPTSGTSVGMST----FSIMDYVVFVLLLVLSLAIGLYHACRGWGRHTVGELLMADRK 65
            :||:...:.|..::|..::    |.:.||.|||::|..|..||:|.......::|..|.|...:|
  Fly     1 MSTTTTTTTTMASAVSSASQDLRFGLTDYFVFVIMLGASAGIGVYFGFFSKSKNTTEEYLRGGKK 65

Human    66 MGCLPVALSLLATFQSAVAILGVPSEIYRFGTQYWFLGCCYFLGLLIPAHIFIPVFYRLHLTSAY 130
            |..||:|:||:|:..|.:||:.:|:|.|.:|..|.|:.....:.:.|..:|.:||||..::::.|
  Fly    66 MQTLPIAISLVASQLSGIAIMSIPAESYTYGFNYIFVVLAMLVVIPILIYIIVPVFYENNVSNCY 130

Human   131 EYLELRFNKTVRVCGTVTFIFQMVIYMGVVLYAPSLALNAVTGFDLWLSVLALGIVCTVYTALGG 195
            ||||:||||..|...|..|:....:.:.|.::.||||...|||.::.|..:.:..:|..||.|||
  Fly   131 EYLEMRFNKRTRQLVTFFFVTNSFLMLPVYMFIPSLAFAQVTGMNIHLINVMVSSICIFYTMLGG 195

Human   196 LKAVIWTDVFQTLVMFLGQLAVIIVGSAKVGGLGRVWAVASQHGRISGFELDPDPFVRHTFWTLA 260
            :|||:||||.|..:|.|..:||.::|:.:.||:..|...||..||.: |:...||.:|.|||...
  Fly   196 IKAVVWTDVVQGAIMLLSVVAVGVLGTIRSGGMFTVMERASDGGRFN-FDFGLDPRIRMTFWGAT 259

Human   261 FGGVFMMLSLYGVNQAQVQRYLS----SRTEKAAVLS--CYAVFPFQQVSLCVGCLIGLVMFA-Y 318
            .||:||.....|:||:.|||.:|    |..:|:.::|  .:.:..|      ...:.|::||| |
  Fly   260 MGGIFMWTGHIGLNQSCVQRIVSLPSYSHAKKSLIVSGLGFLIISF------FNTISGIIMFARY 318

Human   319 YQEYPMSIQQAQAAPDQFVLYFVMDLLKGLPGLPGLFIACLFSGSLSTISSAFNSLATVTMEDLI 383
            |...|| :....:.||:.:.:||.|::..|.|:||:||:|:||.:||::|:..||||.|...|.|
  Fly   319 YGCDPM-LAGLVSKPDKMMPFFVQDIMGHLAGMPGVFISCVFSAALSSLSATLNSLAGVVYFDYI 382

Human   384 RPWFPEFSEARAIMLSRGLAFGYGLLCLGMAYISSQMGPVLQAAISIFGMVGGPLLGLFCLGMFF 448
            :|.. ..:||||....:.:....|..|:...::......:||..::|.|:..|.::|:|.||||.
  Fly   383 KPRI-RHTEARANWAMKLIVVVMGGYCILGGFMVQNFNSILQTVVTITGINTGAVVGVFLLGMFV 446

Human   449 PCANPPGAVVGLLAGLVMAFW-IGIGSIVTSMG--------SSMPPSPSNG-SSFSLPTNLTVAT 503
            |..|...||..::..:|...| |..|.:....|        :|:....:.| ...:...|.|..|
  Fly   447 PRCNAKTAVTSIIVSVVAMVWIIANGQMNFKSGLIKYEVLPNSLDQCEARGLYMIAEAINKTDFT 511

Human   504 VTTLMPLTTFSKPTGLQ-----------RFYSLSYLWYSAHNSTTVIVVGLIVSLLTGRMRGRSL 557
            ..|:.|      |:|..           ..|.:|:.||....|..|.:..:.:|.:.........
  Fly   512 PVTMKP------PSGAPVTTAFHSDRDFSLYDISFYWYKVLGSALVFLCAIPLSYIWRPDENEKQ 570

Human   558 NPATIYPVLPKLLSLLPLSCQ 578
            ||....|.:.|.|| ||::.|
  Fly   571 NPKLYSPFVRKFLS-LPVTDQ 590

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
SLC5A6	NP_066918.2	SLC5sbd_SMVT	24..550	CDD:271394	181/553 (33%)
CG2187	NP_001189331.1	SLC5sbd_NIS-SMVT	27..561	CDD:271383	180/548 (33%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG0591
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D489472at33208
OrthoFinder	1	1.000	-	-		FOG0000151
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X112
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	6	5.820