Protein Alignment SLC5A6 and kumpel

DIOPT Version :10

• Sequence 1: NP_066918.2
• Gene: SLC5A6 / 8884
• HGNCID: 11041
• Length: 635
• Species: Homo sapiens
• Sequence 2: NP_651446.2
• Gene: kumpel / 43136
• FlyBaseID: FBgn0250757
• Length: 698
• Species: Drosophila melanogaster
• Alignment Length: 642
• Identity: 208/642 - (32%)
• Similarity: 312/642 - (48%)
• Gaps: 86/642 - (13%)

Human     1 MSVGVSTSAPLSPTSGTSVGMST-----------------------------------------F 24
            :|..||||:....||..|...||                                         |
  Fly    38 ISSTVSTSSTTGATSTISTSSSTPTTSTTFAYTPTPTPTQSASPSLEDGEEKLSVKDLSQALQHF 102

Human    25 SIMDYVVFVLLLVLSLAIGLYHAC-------------RGWGRHTVGE--------LLMADRKMGC 68
            .|:||:||:.:|.:...||.|...             .|.|...|.|        .|:..|:|..
  Fly   103 GIVDYLVFIAMLAVCAVIGFYFGFIEKKQKKQKLAGKDGGGAAGVEERRGSEALDYLVGGRQMKV 167

Human    69 LPVALSLLATFQSAVAILGVPSEIYRFGTQYWFLGCCYFLGLLIPAHIFIPVFYRLHLTSAYEYL 133
            .||||||:|:|.|.:::||..:|||.:||||.|:.....:...|..:||:|||..|.|||.|||.
  Fly   168 FPVALSLVASFVSGISLLGTSTEIYVYGTQYAFILVTLAISGAISWYIFLPVFCNLQLTSTYEYF 232

Human   134 ELRFNKTVRVCGTVTFIFQMVIYMGVVLYAPSLALNAVTGFDLWLSVLALGIVCTVYTALGGLKA 198
            |.||::.||:.|:..|:...:::..:.:|.|:|.||.|:|..:...|.....:|.:||::||:|.
  Fly   233 ERRFDRRVRIFGSCLFVVMNILWQPICIYVPALTLNQVSGISVSKIVPVTSFICILYTSVGGIKG 297

Human   199 VIWTDVFQTLVMFLGQLAVIIVGSAKVGGLGRVWAVASQHGRISGFELDPDPFVRHTFWTLAFGG 263
            |:||||.|..||....|.|||.|:..:|||..|.....|:.|:.|.::..||..|...:.|..||
  Fly   298 VVWTDVIQGTVMIGSMLIVIIKGTLDLGGLSVVLDHNRQYDRLVGPDMTFDPTARMGVFALFVGG 362

Human   264 VFMMLSLYGVNQAQVQRYL----SSRTEKAAVLSCYAVFPFQQVSLCVGCLIGLVMFA-YYQEYP 323
            ....|...|:|||.|||||    :...:||.|||... |.|..: :||  .|||:.|| :|...|
  Fly   363 ALFKLQANGINQAIVQRYLTLPNNKDVKKALVLSLIG-FMFVML-MCV--YIGLLAFAEFYHCDP 423

Human   324 MSIQQAQAAPDQFVLYFVMDLLKGLPGLPGLFIACLFSGSLSTISSAFNSLATVTMEDLIRPWFP 388
            ::...|: |.||.:..:|:..:..:|||.|||:|.:||.:||::|:|.|||:.|.:.|.:.|:..
  Fly   424 ITTGLAR-AKDQVIPLYVVKNVGHIPGLVGLFVAGVFSAALSSLSTALNSLSGVILTDFVEPFRK 487

Human   389 E-FSEARAIMLSRGLAFGYGLLCLGMAYISSQMGPVLQAAISIFGMVGGPLLGLFCLGMFFPCAN 452
            : .:|.:...|.||:...:||:.:....|..::|.|:|.:.::..:..|||||.|.:||..|...
  Fly   488 KPLTERQTAYLLRGVVISFGLISMASVPIVQRLGLVMQLSSTVAAITCGPLLGAFSVGMLLPFVK 552

Human   453 PPGAVVGL-LAGLVMAFWIGIGSIVTSMGS-SMPPSPSN----GSSFSLPTNLTVATVTTLMPLT 511
            ....:.|: .|....|:.:....|....|| :.|..|.:    ..:|.||.|....|..|    .
  Fly   553 TESLLTGISCASSFTAYIVVRAQIAIFTGSLTFPAKPVSIQDCDYTFDLPANWNATTTAT----P 613

Human   512 TFSKPTGLQRFYSLSYLWYSAHNSTTVIVVGLIVSLLTGRMRGRSLNPATIYPVLPK 568
            |.|...|:   :.:|:|||:|..|...::..|:.:|..||...|.::...|.|||.|
  Fly   614 TESTSHGI---HEISFLWYTAVGSVGTVLGSLLATLYFGRQDPRVVDKELISPVLRK 667

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
SLC5A6	NP_066918.2	SLC5sbd_SMVT	24..550	CDD:271394	190/558 (34%)
kumpel	NP_651446.2	SLC5sbd_NIS-SMVT	105..646	CDD:271383	187/552 (34%)