Protein Alignment SLC5A6 and CG5687

DIOPT Version :10

• Sequence 1: NP_066918.2
• Gene: SLC5A6 / 8884
• HGNCID: 11041
• Length: 635
• Species: Homo sapiens
• Sequence 2: NP_647678.3
• Gene: CG5687 / 38255
• FlyBaseID: FBgn0035293
• Length: 683
• Species: Drosophila melanogaster
• Alignment Length: 578
• Identity: 185/578 - (32%)
• Similarity: 312/578 - (53%)
• Gaps: 36/578 - (6%)

Human     5 VSTSAPLSPTSGTSVGMSTFSIMDYVVFVLLLVLSLAIGLYHACRGWGRHTVGELLMADRKMGCL 69
            :..||.|...|..| ..:|||..|||:.:.:||:||.||:::.....|..:..|.|:.. :|...
  Fly    78 IPASAELEECSAPS-HKATFSGYDYVILLGMLVISLGIGIFYGFFQKGGSSSNEFLLGS-EMSIF 140

Human    70 PVALSLLATFQSAVAILGVPSEIYRFGTQYWFLGCCYFLGLLIPAHIFIPVFYRLHLTSAYEYLE 134
            ||.|||..:|.:|:.:||.|||:|..|||:..:.....:.:.:...||.|:::::.|||.||||.
  Fly   141 PVTLSLTTSFITAIELLGNPSEMYFQGTQFVLIVIPMVIVIPVAVKIFYPIYFKMELTSCYEYLG 205

Human   135 LRFNKTVRVCGTVTFIFQMVIYMGVVLYAPSLALNAVTGFDLWLSVLALGIVCTVYTALGGLKAV 199
            :||.|.:|:.|.|.::.||..|..|.:.||::||:..||.|..::|:.:.:||..|::.||:|||
  Fly   206 IRFGKEIRILGAVLYVIQMCFYTAVAVLAPAIALSKATGLDTKIAVVLIYVVCVFYSSQGGMKAV 270

Human   200 IWTDVFQTLVMFLGQLAVIIVGSAKVGGLGRVWAVASQHGRISGFELDPDPFVRHTFWTLAFGGV 264
            :..|.||..|:.:..:.::.:|....|...:|:..||.|.|:..|.:||||..|||.|::..||.
  Fly   271 VIADSFQAAVLAVSLVLIVGLGCFYSGNPIQVFQTASDHNRLEFFNMDPDPTTRHTVWSVVIGGF 335

Human   265 FMMLSLYGVNQAQVQRYLSSRTEKAAVLSCYAVFPFQQVSLCVGCLI----GLVMFAYYQEYPMS 325
            |...||:..|||.||:.:|.::.:.|.::    ..|..:.|.|..|:    ||::|.:|.:....
  Fly   336 FYWTSLFCTNQASVQKCMSLKSLRLAKIA----LGFAIIGLIVVFLLNFYTGLMVFTHYADCDPL 396

Human   326 IQQAQAAPDQFVLYFVMDLLKGLPGLPGLFIACLFSGSLSTISSAFNSLATVTMED-LIRPWFPE 389
            .....:|.||.:.|:|::..:.:..:.|:|:|.:|:.||.|::||.|||:.||.|| |:.....:
  Fly   397 TAGRISATDQLLPYYVINTYEHISSVAGIFVAGIFAASLGTVASALNSLSAVTCEDLLVNGMNIK 461

Human   390 FSEARAIMLSRGLAFGYGLLCLGMAYISSQMGPVLQAAISIFGMVGGPLLGLFCLGMFFPCANPP 454
            .|..:....::.::.|:|:...|:.:|...:|.||||.:::.|::||..||||.||:....||..
  Fly   462 ISPEKGATYAKWMSLGFGIASFGLVFIVEHLGGVLQATLTLNGLIGGVTLGLFVLGIACKQANTK 526

Human   455 GAVVGLLAGLVMAFWIGIGSIVTSMGSSMPPSPSNGSSFSLPTNLT--VATVTTLMPLTTF---- 513
            ||..|.|..|.:..::|:.:.:.|:  ..|..|::........|:|  :.::.| .||...
  Fly   527 GAFYGGLLSLALVIFVGVVAQIVSV--EQPALPTSIDKCDCHVNMTNIIGSLLT-EPLEVIEEGG 588

Human   514 --SKPTGLQRFYSLSYLWYSAHNSTTVIVVGLIVSLLTGRMRGRSL---------NPA 560
              |.|     .:.|||:|||.......:.:|..:||:...::.|::         |||
  Fly   589 FTSWP-----IFRLSYMWYSMIGCLLTVFLGWFISLIIDFIQRRNVLKITGKDIDNPA 641

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
SLC5A6	NP_066918.2	SLC5sbd_SMVT	24..550	CDD:271394	175/538 (33%)
CG5687	NP_647678.3	SLC5sbd_NIS-SMVT	99..620	CDD:271383	172/533 (32%)