DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment SLC5A6 and CG32669

DIOPT Version :9

Sequence 1:	NP_066918.2	Gene:	SLC5A6 / 8884	HGNCID:	11041	Length:	635	Species:	Homo sapiens
Sequence 2:	NP_727460.1	Gene:	CG32669 / 326229	FlyBaseID:	FBgn0052669	Length:	604	Species:	Drosophila melanogaster

Alignment Length:	572	Identity:	219/572 - (38%)
Similarity:	327/572 - (57%)	Gaps:	42/572 - (7%)

- Green bases have known domain annotations that are detailed below.

Human    21 MSTFSIMDYVVFVLLLVLSLAIGLYHACRGWGRHTVGELLMADRKMGCLPVALSLLATFQSAVAI 85
            |:|....||.:..::|::|:|||:|:...|..:.|..|.|:|||.|...|||.||:|:|.|||.|
  Fly     1 MATLGAWDYTILAVVLIISVAIGIYYRFVGGKQSTTTEYLLADRSMNVAPVAFSLMASFMSAVTI 65

Human    86 LGVPSEIYRFGTQYWFLGCCYFLGLLIPAHIFIPVFYRLHLTSAYEYLELRFNKTVRVCGTVTFI 150
            |||..|.|::||.:..:...|.|...:.|::.|||||||...|.||||||||....|:..:::|.
  Fly    66 LGVSMENYQYGTMFVVINLSYVLSTPVAAYLIIPVFYRLKTASVYEYLELRFGYATRLAASLSFS 130

Human   151 FQMVIYMGVVLYAPSLALNAVTGFDLWLSVLALGIVCTVYTALGGLKAVIWTDVFQTLVMFLGQL 215
            .|||:|||:|:|||:|||.||||.....|::.:|:|||.|..|||:|||:.||::|:|:||....
  Fly   131 LQMVLYMGIVVYAPALALEAVTGLSQVFSIVIVGVVCTFYATLGGMKAVLITDIYQSLLMFAAVF 195

Human   216 AVIIVGSAKVGGLGRVWAVASQHGRISGFELDPDPFVRHTFWTLAFGGVFMMLSLYGVNQAQVQR 280
            :|||....|.|.|..:|.||.::|||:......||..|||::|...||....|::|||||.||||
  Fly   196 SVIICAWVKAGSLEVIWRVAQENGRINLTNFSVDPTERHTWFTQILGGCATYLAIYGVNQTQVQR 260

Human   281 YLSSRTEKAAVLSCYAVFPFQQVSLCV----GCLIGLVMFAYYQEYPMSIQQAQAAPDQFVLYFV 341
            .::.::..||..:.:...|.    ||:    .|..||.::.||::....::....:.||.:..||
  Fly   261 LMAVKSLSAARAALWWCLPI----LCLLSLSTCFSGLCIYWYYRDCDPLLEGRVNSRDQVMPLFV 321

Human   342 MDLLKGLPGLPGLFIACLFSGSLSTISSAFNSLATVTMEDLIRPWFP-----EFSEARAIMLSRG 401
            :|.:....||.|||::.:|..|||||||..:|||.||:||.::|...     ..::.:.:..|:.
  Fly   322 VDTMGEYTGLAGLFVSGIFCASLSTISSIISSLAAVTLEDYLKPLVSCCAKRTLTDRQTLWYSKL 386

Human   402 LAFGYGLLCLGMAYISSQMGPVLQAAISIFGMVGGPLLGLFCLGMFFPCANPPGAVVGLLAGLVM 466
            |:..:|.||:|||:::..:|.:||||:||||::||||||||.|||:...||..||:.|||..|..
  Fly   387 LSLFFGALCIGMAFMAGSIGGLLQAALSIFGIIGGPLLGLFTLGMYVTKANEKGAIGGLLISLAF 451

Human   467 AFWIGIGSIVTSMGSSMPPSPS-NGSSFSLPTNLTVATVTTLMPLTTFSKPTGLQRFYSLSYLWY 530
            .||||       .|...||..| :.|:...|.:.:.|....|..:...::.......|.:||:||
  Fly   452 CFWIG-------FGQPKPPLVSLDMSTAGCPVDRSFARDIFLKTVIAVAEEEHYFYLYRISYMWY 509

Human   531 SAHNSTTVIVVGLIVSLLTGRMRGRSLNPATIYPVLPKLLSLLPLSCQKRLH 582
            :|        :|.:::...|.:             |..|.:||.....:|::
  Fly   510 AA--------LGFLITFFGGWL-------------LSWLFALLKWDNNRRIY 540

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
SLC5A6	NP_066918.2	SLC5sbd_SMVT	24..550	CDD:271394	211/535 (39%)
CG32669	NP_727460.1	SLC5sbd_NIS-SMVT	7..527	CDD:271383	213/551 (39%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C165160503
Domainoid	1	1.000	371	1.000	Domainoid score	I905
eggNOG	1	0.900	-	-		E1_COG0591
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	434	1.000	Inparanoid score	I1707
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D327628at2759
OrthoFinder	1	1.000	-	-		FOG0000151
OrthoInspector	1	1.000	-	-		mtm8669
orthoMCL	1	0.900	-	-		OOG6_101204
Panther	1	1.100	-	-	O	PTHR42985
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R6277
SonicParanoid	1	1.000	-	-		X112
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	1	0.960	-	-
User_Submission	0	0.000	Not matched by this tool.
	14	13.790