DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment SLC5A6 and CG33124

DIOPT Version :9

Sequence 1:	NP_066918.2	Gene:	SLC5A6 / 8884	HGNCID:	11041	Length:	635	Species:	Homo sapiens
Sequence 2:	NP_001097056.3	Gene:	CG33124 / 318891	FlyBaseID:	FBgn0053124	Length:	588	Species:	Drosophila melanogaster

Alignment Length:	597	Identity:	184/597 - (30%)
Similarity:	297/597 - (49%)	Gaps:	69/597 - (11%)

- Green bases have known domain annotations that are detailed below.

Human    24 FSIMDYVVFVLLLVLSLAIGLYHACRGW-----------------------GRHTVGELLMADRK 65
            |..:||.||:.:.:||:|||||.   ||                       |...:.|.||....
  Fly     6 FGTVDYTVFLGVTILSIAIGLYF---GWIKKTKKEMESSPADTPEISIPNFGSKKMNEYLMGSGH 67

Human    66 MGCLPVALSLLATFQSAVAILGVPSEIYRFGTQYWFLGCCYFLGLLIPAHIFIPVFYRLHLTSAY 130
            :...|||:||:|:|.|.|||||.|||||.:||||..:.....:..|..::|::|||..|.:.|:|
  Fly    68 LKVFPVAMSLIASFISGVAILGNPSEIYYYGTQYSLIVLAIVIQGLAVSYIYLPVFSALQVRSSY 132

Human   131 EYLELRFNKTVRVCGTVTFIFQMVIYMGVVLYAPSLALNAVTGFDLWLSVLALGIVCTVYTALGG 195
            |||.:||:..:|...::.|:.::::|...|::.|:||||..:|.::.:..:.:.:||.:||.|||
  Fly   133 EYLGMRFHPLIRNIVSIMFVIEVLLYTPFVVFVPALALNQASGLNIHMIEVLIIVVCVIYTLLGG 197

Human   196 LKAVIWTDVFQTLVMFLGQLAVIIVGSAKVGGLGRVWAVASQHGRISGFELDPDPFVRHTFWTLA 260
            ||||:.||::|.::||...:.|.|:.:..:..|...:......||:....::|.|:||:|.|::.
  Fly   198 LKAVVHTDIWQVVIMFASVVVVAILATCYITDLDDFFESLVDGGRLIFGNINPSPYVRNTVWSVV 262

Human   261 FGGVFMMLSLYGVNQAQVQRYLSSRTEKAAVLSC----------YAVFPFQQVSLCVGCLIGLVM 315
            .||.|...|:..|:|..|.||:|....|.|..|.          |:|..|          :||::
  Fly   263 IGGAFYWTSITAVHQTMVHRYMSLPNLKMARTSIAFFVLGSIIFYSVLSF----------LGLLI 317

Human   316 FAYYQEY-PMSIQQAQAAPDQFVLYFVMDLLKGLPGLPGLFIACLFSGSLSTISSAFNSLATVTM 379
            |..|::. |:|..|.. ..||.|..||:..:..:.|:||||||.:|...||::|...||.:.|.:
  Fly   318 FNMYKDCDPLSAGQIM-NNDQLVPLFVVQSVGHIYGIPGLFIAGIFGAGLSSLSVFLNSTSLVIL 381

Human   380 EDLIRPWFP-EFSEARAIMLSRGLAFGYGLLCLGMAYISSQMGPVLQAAISIFGMVGGPLLGLFC 443
            :|::|..|. :..|..:.::.:......|.|..|...:..::..:|...:|:..:......|:|.
  Fly   382 QDIVRGCFKMQPGETASAIIVKATIVIMGALVFGEVLLLEKVSGILSICMSLVAIATSSTFGIFT 446

Human   444 LGMFFPCANPPGAVVGLLAGLVMAFWIGIGSIVTSMGSSMPPSPSNGSSFSLPTNLTV-----AT 503
            |.:..|.||..|..||.:||.::..||..||.:.:....:.......|..|.|.|:|.     ..
  Fly   447 LAVLVPWANTVGTAVGGIAGFLLTGWITFGSQIAAASGQLHHHRLPVSVASCPGNVTARENVWVD 511

Human   504 VTTLMPLTTFSKPTGLQRFYSLSYLWYSAHNSTTVIVVGLIVSLLTGRMRGRSLNPATIYPVLPK 568
            ...:.||            :.||:.|.:...:.||:|||.:|||:|.....:||:...|.||:.:
  Fly   512 EEQVFPL------------FRLSFHWINPIGALTVVVVGSLVSLVTKPTDIKSLDSDLISPVIHR 564

Human   569 LLSLLPLSCQKR 580
               .||..|.|:
  Fly   565 ---FLPKECFKQ 573

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
SLC5A6	NP_066918.2	SLC5sbd_SMVT	24..550	CDD:271394	174/565 (31%)
CG33124	NP_001097056.3	SLC5sbd_NIS-SMVT	9..533	CDD:271383	165/549 (30%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG0591
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D489472at33208
OrthoFinder	1	1.000	-	-		FOG0000151
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X112
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	6	5.820