Protein Alignment SLC5A6 and rumpel

DIOPT Version :10

• Sequence 1: NP_066918.2
• Gene: SLC5A6 / 8884
• HGNCID: 11041
• Length: 635
• Species: Homo sapiens
• Sequence 2: NP_572397.1
• Gene: rumpel / 31674
• FlyBaseID: FBgn0029950
• Length: 601
• Species: Drosophila melanogaster
• Alignment Length: 597
• Identity: 179/597 - (29%)
• Similarity: 312/597 - (52%)
• Gaps: 54/597 - (9%)

Human    21 MSTFSIMDYVVFVLLLVLSLAIGLYHACR-------------GWGRHTVGELLMADRKMGCLPVA 72
            :.:|...||:||.|:|.:...||:|...:             .....:....|:..|:|...|:.
  Fly    10 LQSFGWPDYLVFCLMLAICAVIGIYFCLQLRLESRKQKANGSEEAASSAASYLVGGRQMKIFPIT 74

Human    73 LSLLATFQSAVAILGVPSEIYRFGTQY-WFLGCCYFLGLLIPAHIFIPVFYRLHLTSAYEYLELR 136
            :||:::|.|.:.:||.|:|:|.:|.|| :.:|....:|..: .:.|:|||:.|:|.|.|:|||.|
  Fly    75 MSLISSFISGITLLGTPTEVYLYGAQYMYIMGSLVLMGFCM-YYFFLPVFHELNLISTYKYLEQR 138

Human   137 FNKTVRVCGTVTFIFQMVIYMGVVLYAPSLALNAVTGFDLWLSVLALGIVCTVYTALGGLKAVIW 201
            :|:::|:.|:|.||...::::.:|:|.|::|.|..||.::.:....:.:||..||.:||||||:|
  Fly   139 YNRSLRLFGSVMFIVASLLWLPIVIYVPAIAFNQATGVNIHIVTPIVCVVCIFYTCIGGLKAVVW 203

Human   202 TDVFQTLVMFLGQLAVIIVGSAKVGGLGRVWAVASQHGRISGFELDPDPFVRHTFWTLAFGGVFM 266
            |||.|||:||.....|:|.|:..:||.|.||..|.:..|:.......|...|:||::|..|||..
  Fly   204 TDVIQTLIMFGAMALVLIKGTLDIGGPGVVWQKAQETARLEVPNFSADLSERYTFYSLVLGGVAH 268

Human   267 MLSLYGVNQAQVQRYLSSRTEKAAVLSCYAVFPFQQVSLCVGCLIGLVMFAYYQEY-PMSIQQAQ 330
            .|....::|..:|||||..|.:.|.::.:.........|.:....||:::|.|.:. |:..:.||
  Fly   269 WLKSNAISQNMIQRYLSLPTLRDARIAIWTFIAGVLAFLMICGYTGLLIYATYSQCDPLETKLAQ 333

Human   331 AAPDQFVLYFVMDLLKGLPGLPGLFIACLFSGSLSTISSAFNSLATVTMEDLIRPWFPE-FSEAR 394
             ..||.:...|||.|...|||||:|:|.:||.:||::|:..|||:.|.:||.::.:... .:|.:
  Fly   334 -RNDQLLPLLVMDTLGSYPGLPGVFVAGVFSAALSSLSTGLNSLSAVVLEDFVKTFRKSPLTEGQ 397

Human   395 AIMLSRGLAFGYGLLCLGMAYISSQMGPVLQAAISIFGMVGGPLLGLFCLGMFFPCANPPGAVVG 459
            ...:.|.:...:|::.:.:.:...::|.|||..|::..:..|||||:|..|:..|..|..||::|
  Fly   398 TAFVMRSVVVVFGIIFVALVFAVEKLGAVLQLTITLSSVANGPLLGIFTAGVMLPWVNSKGALLG 462

Human   460 LLAGLVMAFWIGI--------GSIV------TSMGS--SMPPSPSNGSSFSLPTNLTVATVTTLM 508
            ..:.|::..|:.:        |.:|      ::||.  :....|...:|.:|...::
  Fly   463 GFSSLIVMAWMCVSAQRDLVTGDLVYKRKPYSTMGCNYTFAGEPREFASLALDGAIS-------- 519

Human   509 PLTTFSKPTGLQRFYSLSYLWYSAHNSTTVIVVGLIVSLLTGRMRGRSLNPATIYPVLPKLLSLL 573
                 |.|:...:.|.:|||:::...:...|||.|:.|||........::...:.|.:.:.|
  Fly   520 -----SVPSAPFQLYRISYLYFTLFGALVTIVVALVTSLLLRETDLDGVDTRLLTPFVRRWL--- 576

Human   574 PLSCQKRLHCRS 585
                ::|.|.||
  Fly   577 ----ERRRHRRS 584

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
SLC5A6	NP_066918.2	SLC5sbd_SMVT	24..550	CDD:271394	173/557 (31%)
rumpel	NP_572397.1	SLC5sbd_NIS-SMVT	16..554	CDD:271383	170/552 (31%)